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4 results on '"Dally, Najib"'

1. Can Blood Inflammatory Markers Identify Pregnant Women with Preeclampsia? Still a Controversial Issue.

Author

Braester A, Bilyk A, Suriu C, Akria L, Dally N, and Barhoum M

Subjects
Humans, Female, Pregnancy, Retrospective Studies, Adult, Case-Control Studies, Neutrophils, Mean Platelet Volume, Inflammation blood, Inflammation diagnosis, Predictive Value of Tests, Blood Platelets, Lymphocytes, Pre-Eclampsia blood, Pre-Eclampsia diagnosis, Biomarkers blood
Abstract

Background: Preeclampsia is a unique vascular disease during pregnancy that generally appears after 20 of weeks gestation or until 6 weeks after delivery. Left undiagnosed, preeclampsia can lead rapidly to death of both mother and fetus., Objectives: To verify the efficacy of peripheral blood inflammatory markers (BIMs)in diagnosing preeclampsia and compare them with results from other studies., Methods: Our retrospective case-control study comprised two patient groups. Pregnant women with preeclampsia and pregnant women without preeclampsia were compared for BIMs: neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV). The primary endpoint of our research was to assess the predictive power of BIMs for preeclampsia diagnosis., Results: The sample size was calculated based on expected differences of BIMs between the control and study groups. Comparison of quantitative variables was conducted with independent sample t-test or alternatively by Wilcoxon rank sum test. The MPV values were slightly higher in the preeclampsia group, but not statistically significant. NLR and PLR did differentiate between study and control groups., Conclusions: The diagnostic accuracy of BIMs is unsatisfactory for preeclampsia diagnosis. Discrepancies concerning these values need to be clarified. Further large prospective studies are necessary to validate the potential factor accuracy in preeclampsia diagnosis.

Published
2024

3. A new risk model to predict time to first treatment in chronic lymphocytic leukemia based on heavy chain immunoparesis and summated free light chain

Author

Tamar Tadmor, Yair Herishanu, Andrei Braester, Kelly Townsend, Aaron Polliack, Clara Henig, Lev Shvidel, Naomi Rahimi-Levene, Mona Yuklea, Ariela Arad, Mira Barak, Claudia Fogl, Lee Magal, Rosa Ruchlemer, Ariel Aviv, and Dally Najib

Subjects
Oncology, Male, medicine.medical_specialty, Multivariate analysis, Chronic lymphocytic leukemia, medicine.disease_cause, Subclass, Time-to-Treatment, Risk model, Internal medicine, Medicine, Humans, Prospective cohort study, Aged, Proportional Hazards Models, Aged, 80 and over, business.industry, Time to first treatment, Hazard ratio, Hematology, General Medicine, Immune dysregulation, Middle Aged, Models, Theoretical, medicine.disease, Prognosis, Leukemia, Lymphocytic, Chronic, B-Cell, Female, Immunoglobulin Light Chains, business, Immunoglobulin Heavy Chains, Biomarkers
Abstract

BACKGROUND Chronic lymphocytic leukemia (CLL) is frequently accompanied by immune dysregulation. AIMS In this multicenter prospective study, we investigated whether heavy + light chains (HLC: IgGκ, IgGλ, IgAκ, IgAκ, IgMκ, IgMλ) and IgG subclasses (IgG1, IgG2, IgG3, and IgG4) could be used as novel prognostic markers of immunoparesis in 105 treatment-naive patients with CLL. RESULTS Heavy + light chains immunoparesis of ≥1, ≥2, and ≥3 isotypes was evident in 74 (70%), 58 (55%), and 36 (34%) patients, respectively. Severe HLC immunoparesis was identified in 40 (38%) patients. Of the IgG subclasses, IgG1 and IgG2 were most frequently suppressed, affecting 46 (44%) and 36 (34%) patients, respectively; 63 (60%) patients had low levels of at least one IgG subclass. In multivariate analysis, severe HLC immunoparesis (hazard ratio [HR]: 36.5; P = .010) and ΣFLC ≥ 70 mg/L (HR: 13.2; P = .004) were the only factors independently associated with time to first treatment (TTFT). A risk model including these variables identified patients with 0, 1, and 2 risk factors and significantly different TTFT (P

Published
2019

4. The neutrophil/lymphocyte ratio is a better addition to C-reactive protein than CD64 index as a marker for infection in COPD

Author

Dally Najib, Raymond Farah, Rabia Ibrahim, Majd Nassar, Yifat Zivony, and Elizabeth Eshel

Subjects
Erythrocyte Indices, Male, Time Factors, Exacerbation, Neutrophils, 030204 cardiovascular system & hematology, Severity of Illness Index, Gastroenterology, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Lymphocytes, Prospective Studies, Prospective cohort study, Respiratory Tract Infections, Aged, 80 and over, COPD, medicine.diagnostic_test, biology, Complete blood count, General Medicine, Middle Aged, C-Reactive Protein, Area Under Curve, Disease Progression, Female, Inflammation Mediators, Mean Platelet Volume, Adult, medicine.medical_specialty, 03 medical and health sciences, Predictive Value of Tests, Internal medicine, medicine, Humans, Lymphocyte Count, Mean platelet volume, Aged, business.industry, Receptors, IgG, fungi, C-reactive protein, Case-control study, Reproducibility of Results, Red blood cell distribution width, medicine.disease, respiratory tract diseases, ROC Curve, 030228 respiratory system, Case-Control Studies, Immunology, biology.protein, business, Biomarkers
Abstract

BACKGROUND This study investigated the importance of neutrophil/lymphocyte ratio (NLR) and other new inflammatory markers including CD64 expression in patients with chronic obstructive pulmonary disease (COPD) for identifying the severity of inflammation and recognition of acute exacerbation and infection. METHODS Seventy-two patients with a diagnosis of COPD exacerbation who were admitted to the Department of Internal Medicine B, 13 with stable COPD, and control group of 15 healthy people were enrolled in the study. Complete blood count (CBC), measurement of C-reactive protein (CRP), mean platelet volume (MPV), red blood cell distribution width (RDW) and CD64 expression were determined within 2 hours of hospital admission. RESULTS NLR and other inflammatory markers, such as RDW, CRP, and CD64 were found to be significantly elevated in exacerbated COPD compared to stable COPD and control participants. There was a significant correlation of NLR with CRP (r=0.309, P

Published
2017
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