1. Serjanic Acid Improves Immunometabolic Markers in a Diet-Induced Obesity Mouse Model.
- Author
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Gutiérrez G, Giraldo-Dávila D, Combariza MY, Holzgrabe U, Tabares-Guevara JH, Ramírez-Pineda JR, Acín S, Muñoz DL, Montoya G, and Balcazar N
- Subjects
- Adipose Tissue metabolism, Animals, Body Weight drug effects, Carbohydrate Metabolism drug effects, Diet, High-Fat, Disease Models, Animal, Gene Expression Regulation drug effects, Insulin Secretion drug effects, Liver drug effects, Liver pathology, Mice, Obesity blood, Obesity drug therapy, Organ Size drug effects, Triterpenes chemistry, Triterpenes isolation & purification, Triterpenes pharmacology, Biomarkers metabolism, Obesity immunology, Obesity metabolism, Triterpenes therapeutic use
- Abstract
Plant extracts from Cecropia genus have been used by Latin-American traditional medicine to treat metabolic disorders and diabetes. Previous reports have shown that roots of Cecropia telenitida that contains serjanic acid as one of the most prominent and representative pentacyclic triterpenes. The study aimed to isolate serjanic acid and evaluate its effect in a prediabetic murine model by oral administration. A semi-pilot scale extraction was established and serjanic acid purification was followed using direct MALDI-TOF analysis. A diet induced obesity mouse model was used to determine the impact of serjanic acid over selected immunometabolic markers. Mice treated with serjanic acid showed decreased levels of cholesterol and triacylglycerols, increased blood insulin levels, decreased fasting blood glucose and improved glucose tolerance, and insulin sensitivity. At transcriptional level, the reduction of inflammation markers related to adipocyte differentiation is reported., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
- Published
- 2020
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