1. Aerobic Training and Circulating Neurotrophins in Alzheimer's Disease Patients: A Controlled Trial.
- Author
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Stein, Angelica Miki, Coelho, Flávia Gomes de Melo, Vital-Silva, Thays Martins, Rueda, André Veloso, Pereira, Jessica Rodrigues, Deslandes, Andréa Camaz, Camarini, Rosana, and Santos Galduróz, Ruth Ferreira
- Subjects
NERVE growth factor ,BIOMARKERS ,SOMATOMEDIN ,EXECUTIVE function ,STATISTICS ,AEROBIC exercises ,ALZHEIMER'S disease ,CLINICAL trials ,NOSOLOGY ,ANALYSIS of variance ,CARDIOPULMONARY fitness ,BLOOD plasma ,RESEARCH methodology ,OXYGEN consumption ,EXERCISE physiology ,COGNITION ,TREADMILLS ,BLOOD collection ,PSYCHOLOGICAL tests ,NEUROPSYCHOLOGICAL tests ,PRE-tests & post-tests ,T-test (Statistics) ,EXERCISE intensity ,HEART beat ,LACTATES ,REPEATED measures design ,BRAIN-derived neurotrophic factor ,VASCULAR endothelial growth factors ,DATA analysis ,DATA analysis software ,BLOOD - Abstract
to verify the effects of aerobic exercise training in circulating BDNF, VEGF
165 and IGF-1 plasma levels and cognitive function in Alzheimer's Disease (AD) patients. 34 AD patients participated in the study, divided in two groups: Control Group (CG; n = 16) and Training Group (TG; n = 18 – Moderate aerobic training on the treadmill, three times a week, for 12 weeks). BDNF, VEGF165, and IGF-1 plasma levels were considered as a primary outcome. Secondary outcomes included cognitive functions and aerobic fitness. After 12 weeks, maintenance of executive functioning in the TG was found, yet no significant changes on circulating neurotrophins levels were identified. For aerobic fitness, there was an increment in TG group. Twelve weeks of aerobic training were neither effective in improving cognitive functioning significantly, nor influential on circulating neurotrophins levels in AD patients. [ABSTRACT FROM AUTHOR]- Published
- 2023
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