1. Distinct Nuclear Organization of Telomeresand Centromeres in Monoclonal Gammopathyof Undetermined Significance and Multiple Myeloma.
- Author
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Yu PLI, Wang Y, Tammur P, Tamm A, Punab M, Rangel-Pozzo A, and Mai S
- Subjects
- Aged, Aged, 80 and over, Female, Genomic Instability, Humans, Leukocytes pathology, Male, Middle Aged, Biomarkers, Tumor genetics, Centromere genetics, Monoclonal Gammopathy of Undetermined Significance genetics, Multiple Myeloma genetics, Telomere genetics
- Abstract
Both multiple myeloma (MM) and its precursor state of monoclonal gammopathy of undetermined significance (MGUS) are characterized by an infiltration of plasma cells into the bone marrow, but the mechanisms underlying the disease progression remain poorly understood. Previous research has indicated that 3D nuclear telomeric and centromeric organization may represent important structural indicators for numerous malignancies. Here we corroborate with previously noted differences in the 3D telomeric architecture and report that modifications in the nuclear distribution of centromeres may serve as a novel structural marker with potential to distinguish MM from MGUS. Our findings improve the current characterization of the two disease stages, providing two structural indicators that may become altered in the progression of MGUS to MM., Competing Interests: S.M. is a shareholder, director, and chair of the clinical and scientific advisory board of Telo Genomics Corp. (Toronto, ON, Canada). The other authors declare that they have no conflicts of interest.
- Published
- 2019
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