1. Glutathione S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy.
- Author
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Maniglia MP, Russo A, Biselli-Chicote PM, Oliveira-Cucolo JG, Rodrigues-Fleming GH, -Maniglia JV, Pavarino ÉC, and Goloni-Bertollo EM
- Subjects
- Adult, Aged, Aged, 80 and over, Cisplatin administration & dosage, Female, Fluorouracil administration & dosage, Follow-Up Studies, Genetic Predisposition to Disease, Haplotypes, Head and Neck Neoplasms genetics, Head and Neck Neoplasms therapy, Humans, Male, Methotrexate administration & dosage, Middle Aged, Prognosis, Retrospective Studies, Risk Factors, Squamous Cell Carcinoma of Head and Neck genetics, Squamous Cell Carcinoma of Head and Neck therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Biomarkers, Tumor genetics, Chemoradiotherapy methods, Glutathione S-Transferase pi genetics, Head and Neck Neoplasms pathology, Polymorphism, Genetic, Squamous Cell Carcinoma of Head and Neck pathology
- Abstract
Background/aim: The Glutathione S-transferases (GSTs) are important carcinogen-metabolizing enzymes. Polymorphisms involved in these enzymes can modulate the development and treatment of head and neck cancer. To investigate the association of GSTs polymorphisms with head and neck cancer and risk factors, clinical-pathological features, and survival time of the patients treated with chemotherapy and/or radiotherapy., Methods: The GST gene polymorphisms were evaluated in 197 cases and 514 controls by PCR-RFLP-Polymerase Chain Reaction Restriction Fragment Length Polymorphism., Results: The GSTP-313 was associated with a decreased risk for HNSCC (p=0.050). The GSTP1 haplotype analysis revealed a higher frequency of the AC and AT haplotypes in the case group than in the control group (p=0.013 and p=0.019, respectively), and the opposite for G-C haplotype (p = 0.015). Yet, the different combinations between the genotypes were associated with an increased risk of cancer. The study showed no association between the polymorphisms and primary tumor site, clinical-pathological characteristics, treatment (chemotherapy and/or radiotherapy) and survival time of the patients., Conclusion: The GST polymorphisms combination showed an increased risk for carcinogenesis, and studies with larger casuistry can contribute to the clarification of the role in individual patient differences for the response to chemotherapy and/or radiotherapy and identify biomarkers of susceptibility.
- Published
- 2020
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