1. Molecular analysis of breast sentinel lymph nodes.
- Author
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Blumencranz PW, Pieretti M, Allen KG, and Blumencranz LE
- Subjects
- Adult, Aged, Aged, 80 and over, Axilla, Breast Neoplasms metabolism, Breast Neoplasms therapy, Carcinoma, Ductal, Breast metabolism, Carcinoma, Ductal, Breast therapy, Carcinoma, Lobular metabolism, Carcinoma, Lobular therapy, Female, Humans, Lymph Nodes metabolism, Lymphatic Metastasis, Middle Aged, Neoplasm Invasiveness, Retrospective Studies, Sentinel Lymph Node Biopsy, Biomarkers, Tumor metabolism, Breast Neoplasms diagnosis, Carcinoma, Ductal, Breast diagnosis, Carcinoma, Lobular diagnosis, Lymph Nodes pathology, Standard of Care
- Abstract
Lymphatic mapping and sentinel lymph node (SLN) biopsy have become the standard of care for staging the axilla in patients with invasive breast cancer. Current histologic methods for SLN evaluation have limitations, including subjectivity, limited sensitivity, and lack of standardization. The discovery of molecular markers to detect metastases has been reported over the last 2 decades. The authors review the historical development of these markers and the clinical use of one of the molecular platforms in 478 patients at their institution. Controversies and future directions are discussed., (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Published
- 2011
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