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2. Is the measurement of noxious stimulus-evoked EEG activity a reliable, valid, and interpretable tool to assess analgesic efficacy in neonates? Protocol for a systematic review and individual participant data (IPD) meta-analysis

Author

Massaro, An, Matthews, Danielle, Edress Darsey, Hovinga, Collin, Allegaert, Karel, Ward, Robert, Gunawan, Patricia Yulita, Van Den Anker, John, Kanwaljit Singh, Bhatt, Aomesh, Vivas, Norma, Van Der Vaart, Marianne, Slater, Rebeccah, Davis, Jonathan M, Baxter, Luke, Sheppard, James, Turner, Mark, Discenza, Deb, Mehta, Varsha, and Cobo, Maria M.

Subjects
validity, Medical Sciences, reliability, Neuroscience and Neurobiology, FOS: Clinical medicine, Neurosciences, Life Sciences, Pediatrics, Developmental Neuroscience, Medicine and Health Sciences, Medical Specialties, COSMIN, biomarker, pain, nociception, EEG, neonate, interpretability, electroencephalography
Abstract

This protocol outlines details for an IPD meta-analysis on the measurement properties and interpretability of a brain-based response biomarker of infant acute somatic nociceptive pain. This registration occurred prior to individual participant data collection and analysis.

Published
2023
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