1. Four new dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus and their SIRT1 activation activities
- Author
-
Guan-Tao Zheng, Jian Zhang, Hui-Min Yang, Cui-Hua Jiang, Li-Ping Zhu, Zhi-Qi Yin, and Xian Zheng
- Subjects
China ,Stereochemistry ,Phytochemicals ,Juglandaceae ,chemistry.chemical_compound ,Triterpenoid ,Sirtuin 1 ,Drug Discovery ,Humans ,Monosaccharide ,Glycosides ,Pharmacology ,chemistry.chemical_classification ,Molecular Structure ,biology ,Dammarane ,Glycoside ,Hep G2 Cells ,General Medicine ,biology.organism_classification ,Triterpenes ,Plant Leaves ,Paliurus ,chemistry ,Hepg2 cells ,Cyclocarya - Abstract
Four new C-11 monosaccharide attached dammarane triterpenoid glycosides cypaliurusides S V (1–4), along with nine known dammarane triterpenoid glycosides (5–13) were isolated from a CHCl3-soluble extract of the leaves of Cyclocarya paliurus. All characterized compounds were assayed for their cytotoxicities against HepG2 cells and 10 compounds were evaluated for the agonistic effects on sirtuin1 (SIRT1). The results showed that compounds 1, 5 and 6 were strongly cytotoxic in HepG2 cell line. Two dammarane triterpenoid glycosides 3 and 10 exhibited agonistic activities on SIRT1 with IC50 of 10 μM and 20 μM, respectively.
- Published
- 2021
- Full Text
- View/download PDF