The genus Opuntia, family Cactaceae, originated in Mexico and spread to arid and semiarid regions worldwide. Opuntia ficus-indica (L.) Mill. is one of the most agro-economically important cactus species due to its fruit value with high nutritional and medicinal importance. Fruit can be consumed fresh, processed, or as a juice. Some Opuntia species are wild, and fruit is not suitable for human nutrition, but plants can be used as forage for animal nutrition. Moreover, Opuntia spp. is used to produce cladodes that are widely used as a type of vegetables. Cultivation of Opuntia spp. is an easy process. To achieve good results, several factors should be considered, such as the location, planting method, environmental conditions, soil type, cultural practices, and harvest stage to produce high yield with good quality.