1. Interleukin-6 and granulocyte macrophage-csf in the cerebrospinal fluid from hiv infected subjects with involvement of the central nervous system
- Author
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O. Perrella, E. Izzo, M. Guerriero, Pietro Biagio Carrieri, and Soscia M
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,AIDS Dementia Complex ,Central nervous system ,Enzyme-Linked Immunosorbent Assay ,Granulocyte ,cerebrospinal fluid ,AIDS-demência complexo ,AIDS dementia complex ,lcsh:RC321-571 ,cytokines (interleukin-6, granulocyte-macrophage-CSF) ,Pathogenesis ,Cerebrospinal fluid ,Central Nervous System Diseases ,medicine ,Humans ,Macrophage ,Interleukin 6 ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,líquido cefalorraquidiano ,biology ,Interleukin-6 ,business.industry ,Incidence (epidemiology) ,Granulocyte-Macrophage Colony-Stimulating Factor ,citocinas (interleucina-6, granulócito-macrófago-CSF) ,body regions ,medicine.anatomical_structure ,Granulocyte macrophage colony-stimulating factor ,Neurology ,Immunology ,biology.protein ,Female ,Neurology (clinical) ,business ,medicine.drug - Abstract
We detected the cytokines interleukin-6 (IL-6) and granulocyte macrophage-CSF (GM-CSF) by ELISA in the CSF and serum of 30 HIV-infected patients classified as AIDS dementia complex (ADC), and 20 subjects with other neurological diseases (OND). We have found a high incidence of detectable IL-6 and GM-CSF in the CSF of ADC patients compared with OND patients. No statistical differences were observed between both groups for serum IL-6 and GM-CSF levels. These results suggest an intrathecal synthesis of these cytokines and a possible involvement in the pathogenesis of ADC.
- Published
- 1992