1. The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays
- Subjects
ochratoxin ,International Cooperation ,alkanone ,methapyrilene ,phenobarbital ,Toxicogenetics ,medical research ,isobutyl nitrite ,monuron ,carcinogenicity ,s (1 ,Genotoxic carcinogen ,bromodichloromethane ,vinyl chloride ,arsenate sodium ,chloroprene ,benzo[a]pyrene ,Genomics ,2 dichlorovinyl)cysteine ,potassium bromate ,nifedipine ,Model compounds ,8 tetrachlorodibenzo para dioxin ,priority journal ,Metabonomics ,3 butadiene ,dimethylnitrosamine ,in vitro study ,pirinixic acid ,Carcinogenicity Tests ,chlorothalonil ,review ,2 nitrofluorene ,Physiological Sciences ,dichromate sodium ,Animal Testing Alternatives ,Hazardous Substances ,phorbol 13 acetate 12 myristate ,Non-genotoxic carcinogen ,unindexed drug ,Metabolomics ,Animalia ,Selection criteria ,chemical compound ,human ,European Union ,Biology ,model ,nonhuman ,streptozocin ,screening ,Gene Expression Profiling ,medical information ,piperonyl butoxide ,FP6 project ,asbestos ,tolbutamide ,aflatoxin B1 ,REACH ,cadmium derivative ,carcinoGENOMICS ,Chemical carcinogenesis - Abstract
Recent changes in the European legislation of chemical-related substances have forced the scientific community to speed up the search for alternative methods that could partly or fully replace animal experimentation. The Sixth Framework Program project carcinoGENOMICS was specifically raised to develop omics-based in vitro screens for testing the carcinogenic potential of chemical compounds in a pan-European context. This paper provides an in-depth analysis of the complexity of choosing suitable reference compounds used for creating and fine-tuning the in vitro carcinogenicity assays. First, a number of solid criteria for the selection of the model compounds are defined. Secondly, the strategy followed, including resources consulted, is described and the selected compounds are briefly illustrated. Finally, limitations and problems encountered during the selection procedure are discussed. Since selecting an appropriate set of chemicals is a frequent impediment in the early stages of similar research projects, the information provided in this paper might be extremely valuable. Crown Copyright © 2008.
- Published
- 2008