1. Penicilazaphilones D and E: two new azaphilones from a sponge-derived strain of the fungus Penicillium sclerotiorum
- Author
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Dong-Lin Zhao, Chang-Yun Wang, Jun-Di Hao, Xing-Yan Ning, Chui-Jian Kong, Chao-Yi Wang, Jing-Shuai Wu, and Chang-Lun Shao
- Subjects
biology ,010405 organic chemistry ,Stereochemistry ,General Chemical Engineering ,Positive control ,General Chemistry ,Fungus ,biology.organism_classification ,01 natural sciences ,Penicillium sclerotiorum ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Sponge ,chemistry.chemical_compound ,chemistry ,Side chain ,IC50 ,Tetrahydrofuran - Abstract
Two new azaphilones, penicilazaphilones D (1) and E (2), along with four known analogs (3–6), were obtained from the sponge-derived fungus Penicillium sclerotiorum. Their structures were elucidated on the basis of comprehensive spectroscopic analyses, ECD calculation, single-crystal X-ray diffraction and comparison to the biosynthetically related compound 5. Compound 1 represents the second reported azaphilone with a C-4 aliphatic side chain, and 2 is the first azaphilone with a tetrahydrofuran ring at C-3. Compound 3 displayed strong antiviral activity against HSV (IC50 = 19.5 μM) and EV71 (IC50 = 132 μM), 16 and 3 fold more potent than the positive control ribavirin, respectively.
- Published
- 2018
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