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Objective of the study is to evaluate the role of cadaverine in cholera vibrio adaptation to stress, induced by hypoxia. Materials and methods. Utilized have been 18 V. cholerae strains with different set of pathogenicity determinants. The strains are isolated from patients and from river-water. Results and conclusions. It is demonstrated that under experimental modeling of intestinal tract gas medium, cholera vibrios respond to unfavorable conditions of the environment by producing cadaverine. Its amount coincides with pathogenicity of cultures (it is higher in epidemically significant strains, than in the strains that lack genes of toxin and pilus production). It is established that the level of extracellular cadaverine production is greater than that of intracellular; but correlation of the parameters depends upon the oxygen and carbon dioxide concentration in the environment. Intracellular cadaverine is mainly generated at a high oxygen concentration (10-12 %); while under extreme hypoxia ( 2 ) and in case of carbon dioxide level increase (9-13 %), its production markedly declines.

Represented are the results of studies on variability of properties characterizing persistent potential of V. cholerae in biofilm communities under the long-term cultivation in river water. Demonstrated is the fact that in the cold water epidemically significant cholera vibrios form thin biofilms and do not survive for the most part. But atoxigenic strains, isolated from the water, can survive in the environment both in the cold and warm time of the year due to formation of thick biofilm and realization of the persistent activity. Expressiveness of the properties studied, except antilysozyme activity (ALA), directly correlate with biofilm formation intensity. In case of ALA one observes inverse correlation.