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SummaryIn slices from regenerating rat liver 84 and 168 hours after hepatectomy, oxygen consumption is moderately increased and glycine-1-C14, L-leucine-C14 and L-phenylalanine-C14 incorporation into protein is markedly increased as compared with normal liver slices. On the other hand, in liver homogenates, incubated with succinate or α-ketoglutarate as substrates, oxidative phosphorylation is decreased in the early stages (84 hours) of regeneration. The results suggest the following conclusions: 1) in regenerating liver tissue, amino acid incorporation into protein can increase even without a parallel increase in the aerobic formation of high energy phosphates; 2) in both normal and regenerating rat liver, the availability of ~ P greatly exceeds that needed for protein synthesis.

Gli autori hanno studiatoin vitro il problema della sintesi dell'albumina in sezioni di fegato normale e rigenerante di ratto. La quantita di albumina prodotta durante l'incubazione non presenta notevoli variazioni nelle due situazioni studiate. Al contrario l'incorporazione di glicina marcata nella albumina del fegato rigenerante risulta nettamente aumentata rispetto a quella del fegato normale. Tale comportamento viene interpretato come espressione di un ricambio albuminico piu elevato nel fegato rigenerante che nel normale.

In a 1-year multicenter study the microbial colonization of 1154 central venous catheters (CVCs) was investigated. Catheters explanted either from immunocompromised or immunocompetent patients were collected and analyzed by five clinical microbiology laboratories located in Ancona, Aviano, Catania, Pavia and Rome, Italy.A further aim was to investigate, by scanning electron microscopy, the features of currently used catheters, both new and explanted from patients, analyzing their surface quality, the influence of the host protein biofilm on their microbial colonization, the modifications caused by their permanence in the body and the relationship between these factors and the occurrence of infections.