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56 results on '"S, Mercer"'

1. Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug Response

Author

Chen He, Brian Gudenas, James Dalton, Jason Chiang, Zoran Rankovic, Chang-Hyuk Kwon, Nathaniel R. Twarog, Wenwei Lin, Amar Gajjar, Michelle Monje, Ke Xu, Lawryn H. Kasper, Laura D. Hover, Brent A. Orr, Taosheng Chen, Burgess B. Freeman, Gang Wu, Kimberly S Mercer, Santhosh A. Upadhyaya, Paul Klimo, Yingzhe Wang, Giles W. Robinson, William Caufield, Paige S. Dunphy, Martine F. Roussel, Suzanne J. Baker, Ibrahim Qaddoumi, Cynthia Wetmore, Xiaoyu Li, Jinghui Zhang, Anang A. Shelat, Duane G. Currier, Barbara Jonchere, Christopher L. Tinkle, Paul A. Northcott, Alberto Broniscer, Frederick A. Boop, Junyuan Zhang, and Xiaoyan Zhu

Subjects
Pathogenesis, In vivo, Glioma, DNA methylation, Cancer research, medicine, Context (language use), Biology, Signal transduction, medicine.disease, PI3K/AKT/mTOR pathway, In vitro
Abstract

Pediatric high-grade glioma (pHGG) is a major contributor to cancer-related death in children.In vitroandin vivodisease models reflecting the intimate connection between developmental context and pathogenesis of pHGG are essential to advance understanding and identify therapeutic vulnerabilities. We established 21 patient-derived pHGG orthotopic xenograft (PDOX) models and eight matched cell lines from diverse groups of pHGG. These models recapitulated histopathology, DNA methylation signatures, mutations and gene expression patterns of the patient tumors from which they were derived, and included rare subgroups not well-represented by existing models. We deployed 16 new and existing cell lines for high-throughput screening (HTS).In vitroHTS results predicted variablein vivoresponse to inhibitors of PI3K/mTOR and MEK signaling pathways. These unique new models and an online interactive data portal to enable exploration of associated detailed molecular characterization and HTS chemical sensitivity data provide a rich resource for pediatric brain tumor research.

Published
2020
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2. IMMU-06. T-CELL IMMUNOTHERAPY FOR PEDIATRIC BRAIN TUMORS: DIVERSITY IN CELL SURFACE ANTIGEN AND HLA EXPRESSION NECESSITATES A MULTI-PRONGED APPROACH

Author

Xiaoyan Zhu, Giedre Krenciute, Jason Chiang, Suzanne J. Baker, Kimberly S Mercer, Haley Houke, Martine F. Roussel, Jennifer L. Stripay, and Stephen Gottschalk

Subjects
Cancer Research, Oncology, Antigen, Pediatric brain, Cancer research, AcademicSubjects/MED00300, AcademicSubjects/MED00310, Neurology (clinical), Hla expression, Immunotherapy, Biology, T cell immunotherapy
Abstract

Cell surface or intracellular antigens expressed in pediatric brain tumors are potential targets for chimeric antigen receptor (CAR) or ab (T-cell receptor) TCR T-cell immunotherapy. At present it remains unknown what cell surface antigens are suitable CAR targets for pediatric brain tumors; in addition, cell surface expression of HLA class I, a molecule critical for ab TCR T-cell recognition, has not been systemically studied in these tumors. Therefore, we set out to assess expression of five CAR targets (IL13Ra2, HER2, EphA2, B7-H3, GD2) and HLA class I. We established and validated a flow cytometry-based method to profile CAR targets and HLA class I expression from pediatric patient-derived xenograft (PDX) samples. To date, we profiled 53 PDX samples, including medulloblastoma, HGG, DIPG, ATRT, and ependymoma. We found that antigen expression has high intra- and inter-PDX sample variability with B7-H3 and IL13Ra2 being most consistently expressed. We confirmed these findings using conventional IHC for B7-H3 with PDX samples and patient tissue microarrays. HLA class I was present on the cell surface of HGGs and DIPGs, however significantly down-regulated in 26 out of 36 other brain tumor types. Finally, matched fresh tissue and PDX sample analysis revealed that cells derived from PDX models are indeed representative of fresh tissue. Our results indicate that more than one antigen needs to be targeted to achieve a more complete tumor clearance. In addition, variable expression of HLA class I suggests that pediatric brain tumors have developed immune evasion strategies to prevent recognition by conventional T cells.

Published
2020

3. In Depth Proteome Analysis of Ripening Muscadine Grape Berry cv. Carlos Reveals Proteins Associated with Flavor and Aroma Compounds

Author

Huan He, Rakesh K. Singh, Sheikh M. Basha, Roger S. Mercer, Devaiah Kambiranda, and Kate Calvin

Subjects
0106 biological sciences, 0301 basic medicine, Proteome, Propanols, Berry, 01 natural sciences, Biochemistry, 03 medical and health sciences, Species Specificity, Gene Expression Regulation, Plant, Vitis, Food science, wine.grape_variety, Flavor, Aroma, Plant Proteins, Phenylpropanoid, biology, Chemistry, food and beverages, Ripening, General Chemistry, biology.organism_classification, Vitis rotundifolia, 030104 developmental biology, Fruit, Odorants, wine, Metabolic Networks and Pathways, 010606 plant biology & botany
Abstract

Ripening in nonclimacteric fruits such as grape involves complex chemical changes that have a profound influence on the accumulation of flavor and aroma compounds distinct to a particular grape genotype. In this study, proteome characterization of wine type bronze muscadine grape (Vitis rotundifolia cv. Carlos), primarily grown in the Southeastern United States was performed during berry ripening. Stage-specific protein expression was obtained among different stages of berries. Differential analysis showed the expression of 522 proteins that regulate diverse biological processes and metabolic pathways. Of these, 30 proteins are associated with the production of key phenolic compounds, whereas 25 are associated with the production of muscadine aroma compounds. These proteins are involved in the phenylpropanoid pathway, terpene synthesis, fatty acid derived volatiles and esters that affect muscadine berry flavor and aroma characteristics. Further, gene expression analysis during ripening validated the expression pattern of 12 proteins. Catechin, epicatechin, and four stilbenes were quantified to correlate observed proteome changes. This study not only revealed biochemical changes during muscadine berry ripening but also offers indicators for marker-assisted breeding to enhance organoleptic properties of muscadine grape to improve its flavor and aroma properties.

Published
2016
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4. Fractionation-dependent improvements in proteome resolution in the mouse hippocampus by IEF LC-MS/MS

Author

Joseph L. Bundy, Brian D. Inouye, Richard S. Nowakowski, and Roger S. Mercer

Subjects
0301 basic medicine, Lysis, Chromatography, Resolution (mass spectrometry), Isoelectric focusing, Clinical Biochemistry, Fractionation, Biology, Tandem mass spectrometry, Biochemistry, Analytical Chemistry, 03 medical and health sciences, 030104 developmental biology, Protein sequencing, Proteome, Sample preparation
Abstract

An assessment of fractionated mouse hippocampal peptides was conducted. Protein extract from a single mouse hippocampus was enzymatically digested and fractionated by IEF. Aliquots of fractions were pooled into fewer, more complex samples. The unfractionated lysate, fractions, and pooled fractions were subjected to LC-MS/MS analysis. Samples consisting of many individual fractions had more protein identifications, greater protein sequence coverage, and quantified proteins with more spectral counts than protein extract that was unfractionated or pooled into fewer LC-MS/MS samples. Additionally, prefractionation reduced the median CV for spectral counts as much as 33%. However, the relative gain in proteome resolution was found to saturate with increasing fractionation extent. This study demonstrates how prefractionation by offline IEF can improve the resolution of proteomic investigations of the mouse hippocampus, and that a data-driven pooling methodology can reduce excessive and cost-ineffective fractionation.

Published
2016
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5. Editorial

Author

Judith S. Mercer, Debra A. Erickson-Owens, Siddarth Ramji, Sunil Gomber, and Pooja Dewan

Subjects
Pediatrics, medicine.medical_specialty, Fetus, medicine.diagnostic_test, biology, business.industry, Physiology, Gestational age, Blood volume, Hematocrit, Jaundice, Umbilical cord, Ferritin, medicine.anatomical_structure, Placenta, Pediatrics, Perinatology and Child Health, biology.protein, Medicine, medicine.symptom, business
Abstract

INDIAN PEDIATRICS 747 VOLUME 52__SEPTEMBER 15, 2015 At any point in fetal life, approximately 30% of the fetus’ blood volume is circulating through the placenta where all respiratory and many metabolic functions occur. At birth, allowing this blood to be redistributed to the infant provides up to 50% more iron-rich red blood cells in the circulation [1]. These red blood cells contribute to higher iron stores in infancy [2]. Placental transfusion which facilitates this blood transfer is accomplished in one of three ways: delayed cord clamping (DCC); milking the umbilical cord (UCM) before separating it from the placenta; or clamping and cutting the umbilical cord and milking after cutting (CUCM). Most studies contrast these methods to immediate cord clamping (ICC), the dominant world-wide practice. In term infants, placental transfusion can result in increased iron stores during the first 6 months of life [2]. To date, ferritin, a marker of iron stores, has not been measured in early or late preterm infants in studies of placental transfusion. Measuring ferritin is important because adequate iron is essential for normal brain development, especially during the critical first year when the most rapid brain growth occurs. A recent study of 400 Swedish term infants demonstrated that DCC increased ferritin levels by 48% at 4 months of age. At 4 years of age, those children who had a placental transfusion had higher fine motor and social-emotional scores [3]. In this issue of Indian Pediatrics, Kumar, et al. [4] are the first to report ferritin levels in late preterm infants born between 32 and 36 weeks gestational age [4]. Using CUCM with three milkings, they found ferritin levels almost double at 6 weeks of age in infants who received C-UCM (n=91) when compared to infants (n=86) who received ICC. They also report significantly higher bilirubin levels and an increased need for phototherapy in the C-UCM group. This is in direct contrast to most recent studies on placental transfusion. These important findings suggest the need for further follow-up of these children to determine long-term developmental effects and weigh risks versus benefits. There is no meta-analysis for late preterm infants with placental transfusion. Only two other studies specifically address this age group. The first examined infants between 34-36 weeks (n=41) and compared a 3-minute delay versus ICC [5]. They found higher hemoglobin levels at 1 day and 10 weeks without any difference in jaundice [5]. Ranjit, et al. [6] randomized 94 infants between 30 and 366/7 weeks to either DCC (at least 2 minutes) or ICC. They found higher hematocrit and ferritin levels at 6 weeks of age. The DCC group had longer duration of phototherapy but no difference in the incidence of significant jaundice.

Published
2015
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6. Manganese removal during bench-scale biofiltration

Author

Mark S. Burger, Graham A. Gagnon, Gordon D. Shupe, and Stephen S. Mercer

Subjects
Environmental Engineering, Population, chemistry.chemical_element, Manganese, law.invention, law, Oxidizing agent, Leptothrix, Leptothrix discophora, education, Waste Management and Disposal, Environmental Restoration and Remediation, Filtration, DNA Primers, Water Science and Technology, Civil and Structural Engineering, education.field_of_study, Base Sequence, biology, Reverse Transcriptase Polymerase Chain Reaction, Chemistry, Ecological Modeling, Environmental engineering, biology.organism_classification, Pollution, Environmental chemistry, Biofilter, Water treatment, Adsorption
Abstract

As biological manganese (Mn) removal becomes a more popular water treatment technology, there is still a large gap in understanding the key mechanisms and range of operational characteristics. This research aimed to expand on previous bench-scale experiments by directly comparing small filtration columns inoculated with indigenous biofilms from a Mn filtration plant and filtration columns inoculated with a liquid suspension of Leptothrix discophora SP-6. Batch tests found that in the absence of manganese oxidizing bacteria Mn was not removed by air alone, whereas a mixed population and Leptothrix strain achieved greater than 90% removal of Mn. The bench-scale biofiltration experiments found that biological filters can be inoculated with a pure culture of L. discophora SP-6 and achieve a similar removal of indigenous biofilm. While Mn oxidizing bacteria (MOB) seem to be necessary for the auto-catalytic nature of these biological filters, Mn removal is achieved with a combination of adsorption to Mn oxides and biological oxidation. Additionally, it was demonstrated that biological Mn removal is possible over a broader "field of activity" (e.g., Mn removal occurred at a pH level as low as 6.5) than has previously been reported. The ability of this treatment technology to work over a broader range of influent conditions allows for more communities to consider biological treatment as an option to remove Mn from their drinking water.

Published
2008
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7. Manganese removal and occurrence of manganese oxidizing bacteria in full-scale biofilters

Author

C. A. Krentz, Graham A. Gagnon, S. S. Mercer, and M. S. Burger

Subjects
Environmental Engineering, biology, Health, Toxicology and Mutagenesis, Biofilm, chemistry.chemical_element, Manganese, biology.organism_classification, Microbiology, Agar plate, chemistry, Environmental chemistry, Biofilter, Oxidizing agent, Water treatment, Leptothrix, Bacteria, Water Science and Technology
Abstract

Biological treatment of drinking water to remove manganese (Mn) is becoming more and more common. However, details as to how the technology works remain poorly understood. Some previous studies have focused on bacteria of the genus Leptothrix , identifying them as one of the predominant organisms in Mn oxidizing biofilms. This research took media from inside the filters of four Mn biofiltration plants in the province of New Brunswick, Canada. The water was characterized for all four sites and it was found that Mn removal from all plants is virtually 100%. Biofilm was detached from the sand and tested for presence of Leptothrix using real-tme polymerase chain reaction (RT-PCR) DNA amplification. Less specific testing for Mn oxidizing bacteria was done simultaneously using indicative agar plates. Results showed that only one plant contained Leptothrix in its filters while three of the four plants tested positive for manganese oxidizing bacteria (MOB) through plating. These results, along with other evidence, suggest that while the mechanism of oxidation observed is likely biological, Leptothrix is not necessarily the predominant organism carrying out biooxidation.

Published
2008
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8. Novel Gefitinib Formulation with Improved Oral Bioavailability in Treatment of A431 Skin Carcinoma

Author

Apurva R. Patel, Ravi Doddapaneni, Roger S. Mercer, Mandip Singh, Rakesh K. Singh, and Chandraiah Godugu

Subjects
0301 basic medicine, Proteomics, Skin Neoplasms, Chemistry, Pharmaceutical, Pharmaceutical Science, Biological Availability, Mice, Nude, Antineoplastic Agents, Pharmacology, Rats sprague dawley, Article, Excipients, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Gefitinib, Oral administration, Cell Line, Tumor, Medicine, Animals, Humans, Pharmacology (medical), Epidermal growth factor receptor, Mice nude, biology, business.industry, Organic Chemistry, Survival Analysis, Xenograft Model Antitumor Assays, Bioavailability, Rats, 030104 developmental biology, Solubility, 030220 oncology & carcinogenesis, Area Under Curve, biology.protein, Carcinoma, Squamous Cell, Quinazolines, Molecular Medicine, Caco-2 Cells, Skin Carcinoma, business, Biotechnology, medicine.drug, Biological availability
Abstract

Oral administration of anticancer agents presents a series of advantages for patients. However, most of the anticancer drugs have poor water solubility leading to low bioavailability.Controlled released spray dried matrix system of Gefitinib with hydroxypropyl β-cyclodextrin, chitosan, hydroxy propyl methyl cellulose, vitamin E TPGS, succinic acid were used for the design of formulations to improve the oral absorption of Gefitinib. Spray drying with a customized spray gun which allows simultaneous/pulsatile flow of two different liquid systems through single nozzle was used to prepare Gefitinib spray dried formulations (Gef-SD). Formulation was characterized by in vitro drug release and Caco-2 permeability studies. Pharmacokinetic studies were performed in Sprague Dawley rats. Efficacy of Gef-SD was carried out in A431 xenografts models in nude mice.In Gef-SD group 9.14-fold increase in the AUC was observed compared to free Gef. Improved pharmacokinetic profile of Gef-SD translated into increase (1.75 fold compared to Gef free drug) in anticancer effects. Animal survival was significantly increased in Gef formulation treated groups, with superior reduction in the tumor size (1.48-fold) and volumes (1.75-fold) and also increase in the anticancer effects (TUNEL positive apoptotic cells) was observed in Gef-SD treated groups. Further, western blot, immunohistochemical and proteomics analysis demonstrated the increased pharmacodynamic effects of Gef-SD formulations in A431 xenograft tumor models.Our studies suggested that Gefitinib can be successfully incorporated into control release microparticles based oral formulation with enhanced pharmacokinetic and pharmacodynamic activity. This study demonstrates the novel application of Gef in A431 tumor models.

Published
2015

9. On the Role of the Starved Codon and the Takeoff Site in Ribosome Bypassing in Escherichia coli

Author

K. Heaton, Jonathan Gallant, J. Cabellon, Gurjeet Gill, Dale Lindsley, Paul Bonthuis, Brenna Kelley-Clarke, H. Vu, S. Mercer, L. MacDonald, and A. Worsley

Subjects
Genetics, Binding Sites, Base Sequence, Molecular Sequence Data, Shine-Dalgarno sequence, Wobble base pair, RNA, Transfer, Amino Acyl, Biology, Ribosomal RNA, Ribosome, RNA, Bacterial, A-site, Lac Operon, Start codon, Biochemistry, Structural Biology, Protein Biosynthesis, Codon usage bias, Escherichia coli, P-site, Amino Acid Sequence, Codon, Ribosomes, Molecular Biology
Abstract

Translating ribosomes can skip over stretches of messenger RNA and resume protein chain elongation after a "bypassed" region. We have previously shown that limitation for isoleucyl-tRNA can initiate a ribosome bypass when an AUA codon is in the ribosomal A-site. We have now generalized this effect to other "hungry" codons calling for four different limiting aminoacyl-tRNA species, suggesting that a pause at any A-site will have this effect. We have assessed bypassing in a large family of reporters with nearly every different triplet in the "takeoff site", i.e. the P-site on the 5' side of the hungry codon, and an identical "landing site" codon 16 nucleotides downstream. The different takeoff sites vary over a factor of 50 in bypassing proficiency. At least part of this variation appears to reflect stability of the codon Colon, two colons anticodon interaction at the takeoff site, as indicated by the following: (a) the bypassing proficiency of different tRNAs shows a rough correlation with the frequency of A Colon, two colons U as opposed to G Colon, two colons C pairs in the codon Colon, two colons anticodon association; (b) specific tRNAs bypass more frequently from codons ending in U than from their synonym ending in C; (c) an arginine tRNA with Inosine in the wobble position which reads CGU, CGC, and CGA bypasses much more frequently from the last codon than the first two synonyms.

Published
2004
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10. The Anxiolytic and Antidepressant-like Effects of Testosterone and Estrogen in Gonadectomized Male Rats

Author

Nicole Carrier, Mohamed Kabbaj, Huan He, Samantha K. Saland, Florian Duclot, and Roger S. Mercer

Subjects
Male, medicine.medical_specialty, medicine.drug_class, Gene Expression, Hypothalamic–pituitary–gonadal axis, Anxiety, Motor Activity, Anxiolytic, Hippocampus, Article, Rats, Sprague-Dawley, Internal medicine, medicine, Animals, Testosterone, Castration, Aromatase, Biological Psychiatry, biology, Fadrozole, business.industry, Aromatase Inhibitors, Depression, Dentate gyrus, Testosterone (patch), Estrogens, Androgen, Antidepressive Agents, Rats, Endocrinology, Anti-Anxiety Agents, Estrogen, biology.protein, business, Hormone
Abstract

While the influence of testosterone levels on vulnerability to affective disorders is not straightforward, research suggests this hormone may confer some degree of resiliency in men. We recently demonstrated a role for the dentate gyrus in mediating testosterone's protective effects on depressive-like behavior in gonadectomized male rats. Here, testosterone may exert its effects through androgen receptor-mediated mechanisms or via local aromatization to estradiol.Gonadectomized male rats were implanted with a placebo, testosterone, or estradiol pellet, and subsequent protective anxiolytic- and antidepressant-like effects of testosterone and its aromatized metabolite, estradiol, were then investigated in the open field and sucrose preference tests, respectively. Moreover, their influence on gene expression in the hippocampus was analyzed by genome-wide complementary DNA microarray analysis. Finally, the contribution of testosterone's aromatization within the dentate gyrus was assessed by local infusion of the aromatase inhibitor fadrozole, whose efficacy was confirmed by liquid chromatography-tandem mass spectrometry.Both hormones had antidepressant-like effects associated with a substantial overlap in transcriptional regulation, particularly in synaptic plasticity- and mitogen-activated protein kinase pathway-related genes. Further, chronic aromatase inhibition within the dentate gyrus blocked the protective effects of testosterone.Both testosterone and estradiol exhibit anxiolytic- and antidepressant-like effects in gonadectomized male rats, while similarly regulating critical mediators of these behaviors, suggesting common underlying mechanisms. Accordingly, we demonstrated that testosterone's protective effects are mediated, in part, by its aromatization in the dentate gyrus. These findings thus provide further insight into a role for estradiol in mediating the protective anxiolytic- and antidepressant-like effects of testosterone.

Published
2015

11. Mutations in proteins of the Conserved Oligomeric Golgi Complex affect polarity, cell wall structure, and glycosylation in the filamentous fungus Aspergillus nidulans

Author

Terry W. Hill, A.C. Gauthier, Sara Gremillion, S. Mercer, Susan G. W. Kaminskyj, Loretta Jackson-Hayes, Darlene M. Loprete, Steven D. Harris, and A.J. Ravita

Subjects
Glycosylation, Saccharomyces cerevisiae Proteins, Protein subunit, Mutant, Molecular Sequence Data, Vesicular Transport Proteins, Golgi Apparatus, Saccharomyces cerevisiae, Gene mutation, Microbiology, Aspergillus nidulans, Fungal Proteins, symbols.namesake, chemistry.chemical_compound, Cell Wall, Genetics, Amino Acid Sequence, biology, Conserved oligomeric Golgi complex, Wild type, Cell Polarity, Membrane Transport Proteins, Golgi apparatus, biology.organism_classification, Biochemistry, chemistry, Mutation, symbols
Abstract

We have described two Aspergillus nidulans gene mutations, designated podB1 (polarity defective) and swoP1 (swollen cell), which cause temperature-sensitive defects during polarization. Mutant strains also displayed unevenness and abnormal thickness of cell walls. Un-polarized or poorly-polarized mutant cells were capable of establishing normal polarity after a shift to a permissive temperature, and mutant hyphae shifted from permissive to restrictive temperature show wall and polarity abnormalities in subsequent growth. The mutated genes (podB=AN8226.3; swoP=AN7462.3) were identified as homologues of COG2 and COG4, respectively, each predicted to encode a subunit of the multi-protein COG (Conserved Oligomeric Golgi) Complex involved in retrograde vesicle trafficking in the Golgi apparatus. Down-regulation of COG2 or COG4 resulted in abnormal polarization and cell wall staining. The GFP-tagged COG2 and COG4 homologues displayed punctate, Golgi-like localization. Lectin-blotting indicated that protein glycosylation was altered in the mutant strains compared to the wild type. A multicopy expression experiment showed evidence for functional interactions between the homologues COG2 and COG4 as well as between COG2 and COG3. To date, this work is the first regarding a functional role of the COG proteins in the development of a filamentous fungus.

Published
2014

12. Assessment of imposex in the dogwhelkNucella lapillus(L.) and tributyltin along the northeast coast of England

Author

S. T. Hawkins, S. M. Evans, Chris Frid, E. W. Douglas, T. S. Mercer, and C. L. Scott

Subjects
Imposex, geography, geography.geographical_feature_category, biology, Ecology, Estuary, biology.organism_classification, Fishery, chemistry.chemical_compound, chemistry, Gastropoda, Tributyltin, Juvenile, Animal Science and Zoology, Penis size, Mollusca, Developmental Biology, Nucella
Abstract

Summary Concentrations of tributyltin (TBT) less than 5 ng/l were recorded in most coastal water samples taken from a series of sites in north-east England during autumn 1991. Levels in the industrialized Tyne estuary still exceeded the Environmental Quality Standard (EQS) in 1991 but had fallen from values recorded in 1989–90. Coastal dogwhelk Nucella lapillus (L.) samples taken in 1991 had low concentrations of

Published
1993
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13. Abstracts for the committee on the genetic constitution of chromosome 11

Author

P. Pearson, Christopher J. Rawlings, M. Tolley, A.-M. Frischauf, D. Louis, A.L. Hillyard, R. Williamson, C. Junien, E. Chang, P. Fain, H. Lehrach, J. Schmidtke, A. Torroni, P. Simpson, A. Menon, P. Goodfellow, D.C. Wallace, K. Klinger, J.M. Shoffner, S.H. Laval, M.T. Davisson, P.A. Lalley, P. Ceverha, D.T. Bishop, M.T. Lott, D.P. Doolittle, Y. Nakamura, Brien, I. Henry, I. Newsham, M. Skolnick, D. Hewett, B. Maidak, A. Schinzel, J.M. Trent, Y. Kaneko, B. Emanuel, D.N. Cooper, C. Coutelle, M. Chipperfield, N. Affara, M. Kaelbling, Judi E. Hewitt, B. Ponder, T. Monaco, J.A. Marshall Graves, D.L. Neil, C. Linch, J. Peters, H.P. Klinger, K. Langley, M M Le Beau, F. Mitelman, B.J.B. Keats, J. Ott, A. Bowcock, B.R. Seizinger, W. Cavenee, J. Decker, S. Bryant, Gareth Maslen, S. Naylor, C. Brunn, A.v. Deimling, S. Malik, J. Frézal, R.J. Robbins, B. Keats, A.G. Searle, S.L. Sherman, K. Kidd, D. Cox, E. Southern, J. Beckmann, Frank H. Collins, S. Mercer, and R.E. Lucier

Subjects
Genetics, Chromosome (genetic algorithm), Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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14. Abstracts for the committee on the genetic constitution of chromosome 21

Author

J. Schmidtke, D. Louis, M. Skolnick, Brien, S. Malik, P. Fain, M.T. Davisson, S. Naylor, D. Hewett, P. Pearson, A. Menon, D.N. Cooper, D.L. Neil, M. Tolley, A.-M. Frischauf, P. Goodfellow, K. Langley, K. Klinger, J. Frézal, Christopher J. Rawlings, C. Coutelle, E. Chang, A. Torroni, J.M. Shoffner, A. Bowcock, B. Maidak, H. Lehrach, P. Simpson, B.J.B. Keats, B. Ponder, A.L. Hillyard, F. Mitelman, D. Cox, Judi E. Hewitt, M M Le Beau, T. Monaco, J.A. Marshall Graves, M. Chipperfield, M.T. Lott, P.A. Lalley, P. Ceverha, C. Linch, J. Peters, J. Ott, A.v. Deimling, Y. Nakamura, B.R. Seizinger, Y. Kaneko, C. Brunn, B. Emanuel, D.T. Bishop, R. Williamson, J. Decker, N. Affara, M. Kaelbling, H.P. Klinger, D.C. Wallace, W. Cavenee, A. Schinzel, J.M. Trent, I. Henry, C. Junien, S.H. Laval, D.P. Doolittle, I. Newsham, Frank H. Collins, S. Mercer, J. Beckmann, R.E. Lucier, K. Kidd, E. Southern, Gareth Maslen, R.J. Robbins, B. Keats, A.G. Searle, S.L. Sherman, and S. Bryant

Subjects
Genetics, Constitution, media_common.quotation_subject, Biology, Chromosome 21, Molecular Biology, Genetics (clinical), media_common
Published
1991
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15. Contents Vol. 58, 1991

Author

D. Louis, A.v. Deimling, D. Cox, Brien, S.L. Sherman, J. Frézal, M.T. Davisson, A.L. Hillyard, J. Schmidtke, K. Kidd, J. Decker, P. Fain, J.M. Trent, M M Le Beau, B.R. Seizinger, W. Cavenee, D.N. Cooper, D.P. Doolittle, I. Newsham, P. Goodfellow, S. Naylor, A. Menon, R. Williamson, M. Chipperfield, Christopher J. Rawlings, E. Southern, C. Junien, P. Pearson, M. Skolnick, S. Malik, C. Linch, B. Ponder, Gareth Maslen, J. Peters, C. Coutelle, A.-M. Frischauf, J. Beckmann, D.T. Bishop, M. Tolley, M.T. Lott, H. Lehrach, P. Simpson, R.E. Lucier, Y. Nakamura, S.H. Laval, R.J. Robbins, B. Keats, A.G. Searle, J.M. Shoffner, K. Klinger, E. Chang, B.J.B. Keats, B. Maidak, A. Bowcock, F. Mitelman, Judi E. Hewitt, T. Monaco, A. Torroni, J.A. Marshall Graves, D.L. Neil, P.A. Lalley, P. Ceverha, S. Bryant, K. Langley, N. Affara, M. Kaelbling, B. Emanuel, Y. Kaneko, H.P. Klinger, D.C. Wallace, A. Schinzel, C. Brunn, J. Ott, D. Hewett, I. Henry, Frank H. Collins, and S. Mercer

Subjects
Botany, Genetics, Zoology, Biology, Molecular Biology, Genetics (clinical)
Published
1991
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16. Abstracts for the committee on the genetic constitution of chromosome 17

Author

P. Pearson, K. Klinger, K. Kidd, E. Southern, J. Beckmann, A.-M. Frischauf, Christopher J. Rawlings, D.C. Wallace, R.E. Lucier, D.T. Bishop, A. Schinzel, A. Menon, H. Lehrach, P. Simpson, M. Chipperfield, M.T. Lott, Y. Nakamura, E. Chang, J. Schmidtke, P.A. Lalley, P. Ceverha, C. Linch, D. Hewett, J. Peters, Brien, P. Goodfellow, B. Emanuel, S. Malik, W. Cavenee, A. Torroni, M. Skolnick, S. Bryant, R. Williamson, J. Ott, D.P. Doolittle, I. Newsham, Y. Kaneko, D.L. Neil, H.P. Klinger, C. Coutelle, S.L. Sherman, K. Langley, M.T. Davisson, J. Decker, N. Affara, M. Kaelbling, C. Brunn, D. Cox, Frank H. Collins, S. Mercer, M M Le Beau, D. Louis, S. Naylor, A. Bowcock, A.v. Deimling, A.L. Hillyard, B.R. Seizinger, Gareth Maslen, J. Frézal, R.J. Robbins, B. Keats, B.J.B. Keats, A.G. Searle, M. Tolley, P. Fain, I. Henry, B. Ponder, D.N. Cooper, F. Mitelman, J.M. Shoffner, B. Maidak, Judi E. Hewitt, T. Monaco, J.A. Marshall Graves, C. Junien, S.H. Laval, and J.M. Trent

Subjects
Genetics, Chromosome 17 (human), Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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17. Abstracts for the committee on the genetic constitution of chromosome 9

Author

A. Menon, P. Goodfellow, C. Coutelle, D.L. Neil, M. Chipperfield, K. Langley, C. Linch, J. Peters, B.R. Seizinger, M.T. Lott, B.J.B. Keats, Y. Nakamura, J.M. Shoffner, M M Le Beau, B. Maidak, B. Ponder, S. Bryant, Judi E. Hewitt, M.T. Davisson, T. Monaco, A. Bowcock, J.A. Marshall Graves, Christopher J. Rawlings, J. Schmidtke, Gareth Maslen, C. Brunn, A.L. Hillyard, D.N. Cooper, J.M. Trent, P. Pearson, K. Kidd, S. Naylor, H. Lehrach, J. Decker, P. Simpson, P. Fain, R.J. Robbins, B. Keats, A.G. Searle, S.L. Sherman, E. Chang, D. Louis, Brien, C. Junien, D. Cox, F. Mitelman, I. Henry, P.A. Lalley, P. Ceverha, A.-M. Frischauf, A. Torroni, Y. Kaneko, S.H. Laval, E. Southern, M. Tolley, J. Ott, D. Hewett, D.P. Doolittle, J. Beckmann, I. Newsham, R.E. Lucier, R. Williamson, Frank H. Collins, S. Mercer, K. Klinger, S. Malik, B. Emanuel, N. Affara, M. Kaelbling, W. Cavenee, H.P. Klinger, A.v. Deimling, J. Frézal, M. Skolnick, D.C. Wallace, A. Schinzel, and D.T. Bishop

Subjects
Genetics, Constitution, media_common.quotation_subject, Chromosome 9, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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18. Abstracts for the committee on linkage and gene order

Author

S.L. Sherman, D.L. Neil, D.N. Cooper, E. Chang, K. Langley, A. Menon, A. Torroni, A.L. Hillyard, C. Brunn, M.T. Lott, C. Junien, K. Kidd, C. Coutelle, M.T. Davisson, Y. Nakamura, J. Frézal, B. Emanuel, J. Decker, E. Southern, M M Le Beau, S. Naylor, J. Schmidtke, D. Louis, D. Cox, Brien, Frank H. Collins, S. Mercer, B.J.B. Keats, P.A. Lalley, P. Ceverha, D. Hewett, S. Bryant, M. Tolley, H.P. Klinger, S. Malik, Y. Kaneko, W. Cavenee, M. Chipperfield, M. Skolnick, Gareth Maslen, S.H. Laval, C. Linch, J. Peters, B.R. Seizinger, J. Beckmann, D.P. Doolittle, I. Newsham, Christopher J. Rawlings, J. Ott, R.J. Robbins, B. Keats, A.G. Searle, R.E. Lucier, F. Mitelman, J.M. Trent, H. Lehrach, P. Simpson, A. Bowcock, D.C. Wallace, A.v. Deimling, R. Williamson, P. Fain, K. Klinger, P. Goodfellow, N. Affara, M. Kaelbling, B. Ponder, A. Schinzel, I. Henry, P. Pearson, A.-M. Frischauf, D.T. Bishop, J.M. Shoffner, B. Maidak, Judi E. Hewitt, T. Monaco, and J.A. Marshall Graves

Subjects
Linkage (software), Genetics, Order (business), Biology, Molecular Biology, Gene, Genetics (clinical)
Published
1991
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19. Abstracts for the committee on the genetic constitution of chromosome 22

Author

F. Mitelman, A. Menon, J. Schmidtke, C. Coutelle, M. Skolnick, Frank H. Collins, S. Mercer, Brien, R. Williamson, P. Pearson, J.M. Trent, Gareth Maslen, A.-M. Frischauf, D.L. Neil, M.T. Lott, N. Affara, M. Kaelbling, M. Tolley, K. Langley, D. Cox, B. Ponder, Y. Nakamura, P.A. Lalley, P. Ceverha, R.J. Robbins, B. Keats, A.G. Searle, S.L. Sherman, D.T. Bishop, J. Ott, W. Cavenee, J.M. Shoffner, A. Bowcock, E. Chang, C. Junien, M M Le Beau, C. Brunn, A.L. Hillyard, B.R. Seizinger, K. Klinger, A. Torroni, Christopher J. Rawlings, B. Maidak, Judi E. Hewitt, T. Monaco, J.A. Marshall Graves, D. Louis, Y. Kaneko, S.H. Laval, P. Goodfellow, H. Lehrach, P. Simpson, M.T. Davisson, M. Chipperfield, S. Bryant, B.J.B. Keats, D.C. Wallace, C. Linch, S. Naylor, J. Peters, D. Hewett, A. Schinzel, J. Decker, J. Beckmann, R.E. Lucier, P. Fain, K. Kidd, E. Southern, D.N. Cooper, D.P. Doolittle, I. Newsham, A.v. Deimling, J. Frézal, I. Henry, S. Malik, B. Emanuel, and H.P. Klinger

Subjects
Genetics, Constitution, media_common.quotation_subject, Biology, Molecular Biology, Chromosome 22, Genetics (clinical), media_common
Published
1991
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20. Abstracts for the committee on the genetic constitution of chromosome 8

Author

A.-M. Frischauf, J. Beckmann, B.R. Seizinger, A. Menon, C. Coutelle, R.E. Lucier, J.M. Shoffner, B.J.B. Keats, R. Williamson, B. Maidak, Frank H. Collins, S. Mercer, D. Louis, K. Kidd, E. Chang, C. Junien, Judi E. Hewitt, K. Klinger, T. Monaco, S. Bryant, Brien, J.A. Marshall Graves, D.C. Wallace, E. Southern, D. Hewett, A. Torroni, A. Bowcock, M M Le Beau, Gareth Maslen, B. Emanuel, A. Schinzel, D.L. Neil, S.H. Laval, D. Cox, J. Ott, P. Fain, C. Brunn, F. Mitelman, H.P. Klinger, J. Frézal, K. Langley, N. Affara, M. Kaelbling, D.N. Cooper, R.J. Robbins, A.L. Hillyard, P. Goodfellow, B. Keats, A.G. Searle, J.M. Trent, S.L. Sherman, Christopher J. Rawlings, M. Tolley, P.A. Lalley, P. Ceverha, J. Schmidtke, M. Chipperfield, D.P. Doolittle, M.T. Davisson, C. Linch, J. Peters, I. Newsham, H. Lehrach, P. Simpson, B. Ponder, M. Skolnick, S. Naylor, J. Decker, S. Malik, Y. Kaneko, I. Henry, D.T. Bishop, A.v. Deimling, M.T. Lott, Y. Nakamura, W. Cavenee, and P. Pearson

Subjects
Genetics, Chromosome (genetic algorithm), Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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21. Index of authors of abstracts

Author

D. Louis, C. Junien, J. Frézal, C. Brunn, A. Bowcock, A.v. Deimling, S. Malik, B. Ponder, J. Schmidtke, B.R. Seizinger, F. Mitelman, J.M. Shoffner, S.H. Laval, Christopher J. Rawlings, M. Tolley, D. Cox, A. Menon, J. Decker, P.A. Lalley, P. Ceverha, M. Skolnick, B. Maidak, Judi E. Hewitt, T. Monaco, J.A. Marshall Graves, P. Goodfellow, P. Pearson, D.L. Neil, I. Henry, M. Chipperfield, Y. Kaneko, K. Langley, E. Chang, A.L. Hillyard, H. Lehrach, P. Simpson, C. Linch, C. Coutelle, J. Ott, A.-M. Frischauf, J. Peters, A. Torroni, D.T. Bishop, S.L. Sherman, D.N. Cooper, Brien, M.T. Davisson, D.C. Wallace, B.J.B. Keats, S. Naylor, P. Fain, Gareth Maslen, A. Schinzel, M.T. Lott, R.J. Robbins, B. Keats, Y. Nakamura, A.G. Searle, S. Bryant, D. Hewett, R. Williamson, J. Beckmann, R.E. Lucier, B. Emanuel, K. Kidd, H.P. Klinger, N. Affara, M. Kaelbling, E. Southern, K. Klinger, W. Cavenee, M M Le Beau, Frank H. Collins, S. Mercer, D.P. Doolittle, I. Newsham, and J.M. Trent

Subjects
Index (economics), Statistics, Genetics, Biology, Bioinformatics, Molecular Biology, Genetics (clinical)
Published
1991
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22. Abstracts for the committee on the genetic constitution of chromosome 2

Author

J.M. Trent, K. Kidd, M.T. Lott, Y. Nakamura, C. Junien, B.R. Seizinger, S.H. Laval, Brien, E. Southern, D.C. Wallace, J. Beckmann, J. Ott, M. Tolley, A. Schinzel, A. Menon, R.E. Lucier, F. Mitelman, I. Henry, C. Coutelle, M.T. Davisson, P. Fain, M. Chipperfield, C. Linch, J. Peters, M M Le Beau, P. Goodfellow, D.P. Doolittle, D.T. Bishop, Christopher J. Rawlings, I. Newsham, R. Williamson, W. Cavenee, A.v. Deimling, J.M. Shoffner, A. Bowcock, K. Klinger, J. Frézal, D. Louis, B. Maidak, Frank H. Collins, S. Mercer, S. Naylor, Judi E. Hewitt, H. Lehrach, P. Simpson, B. Emanuel, T. Monaco, D.L. Neil, J.A. Marshall Graves, B. Ponder, H.P. Klinger, D. Cox, K. Langley, J. Decker, P.A. Lalley, P. Ceverha, N. Affara, M. Kaelbling, S. Malik, E. Chang, J. Schmidtke, S.L. Sherman, Y. Kaneko, C. Brunn, M. Skolnick, A. Torroni, D. Hewett, S. Bryant, B.J.B. Keats, Gareth Maslen, A.L. Hillyard, R.J. Robbins, B. Keats, A.G. Searle, P. Pearson, A.-M. Frischauf, and D.N. Cooper

Subjects
Genetics, Chromosome (genetic algorithm), Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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23. Abstracts for the committee on the genetic constitution of chromosome 15

Author

K. Klinger, P. Pearson, N. Affara, M. Kaelbling, C. Junien, A.-M. Frischauf, P. Goodfellow, K. Kidd, Frank H. Collins, S. Mercer, D.L. Neil, D.C. Wallace, K. Langley, Christopher J. Rawlings, M.T. Lott, J.M. Shoffner, R. Williamson, A. Schinzel, J. Ott, D.T. Bishop, D.N. Cooper, Y. Nakamura, S.H. Laval, B. Maidak, Judi E. Hewitt, H. Lehrach, T. Monaco, B. Emanuel, S. Bryant, P. Simpson, B.R. Seizinger, E. Southern, J.A. Marshall Graves, A.v. Deimling, C. Brunn, S.L. Sherman, M. Tolley, H.P. Klinger, Brien, J.M. Trent, J. Decker, J. Beckmann, A. Menon, W. Cavenee, D. Cox, J. Schmidtke, R.E. Lucier, P. Fain, J. Frézal, E. Chang, M M Le Beau, D.P. Doolittle, B. Ponder, P.A. Lalley, P. Ceverha, I. Newsham, C. Coutelle, M. Chipperfield, M. Skolnick, A. Torroni, D. Louis, C. Linch, Gareth Maslen, J. Peters, Y. Kaneko, M.T. Davisson, B.J.B. Keats, R.J. Robbins, B. Keats, S. Malik, A.G. Searle, S. Naylor, A. Bowcock, F. Mitelman, D. Hewett, A.L. Hillyard, and I. Henry

Subjects
Genetics, Chromosome 15, Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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24. Abstracts for the committee on comparative gene mapping

Author

Brien, D.N. Cooper, Gareth Maslen, R.J. Robbins, B. Keats, A.G. Searle, I. Henry, J.M. Shoffner, D.T. Bishop, J. Schmidtke, W. Cavenee, S. Bryant, S.L. Sherman, B. Emanuel, B. Maidak, Judi E. Hewitt, H.P. Klinger, T. Monaco, J.A. Marshall Graves, M. Skolnick, A.L. Hillyard, M M Le Beau, B. Ponder, B.J.B. Keats, D. Cox, N. Affara, M. Kaelbling, P.A. Lalley, P. Ceverha, Y. Kaneko, A. Menon, D. Louis, Christopher J. Rawlings, H. Lehrach, P. Simpson, M. Tolley, C. Coutelle, F. Mitelman, R. Williamson, D. Hewett, P. Fain, B.R. Seizinger, K. Klinger, P. Pearson, E. Chang, Frank H. Collins, S. Mercer, J. Ott, P. Goodfellow, A.-M. Frischauf, D.P. Doolittle, I. Newsham, A. Torroni, J.M. Trent, M.T. Davisson, S. Naylor, S. Malik, K. Kidd, M. Chipperfield, M.T. Lott, C. Junien, Y. Nakamura, C. Linch, J. Peters, J. Frézal, S.H. Laval, E. Southern, J. Decker, D.L. Neil, K. Langley, A. Bowcock, J. Beckmann, R.E. Lucier, A.v. Deimling, D.C. Wallace, A. Schinzel, and C. Brunn

Subjects
Genetics, Gene mapping, Computational biology, Biology, Molecular Biology, Genetics (clinical)
Published
1991
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25. Abstracts for the committee on the genetic constitution of chromosome 12

Author

I. Henry, J. Beckmann, B. Emanuel, J. Frézal, Christopher J. Rawlings, M.T. Davisson, P.A. Lalley, P. Ceverha, C. Junien, J. Schmidtke, R. Williamson, R.E. Lucier, H.P. Klinger, D.C. Wallace, S. Naylor, Y. Kaneko, J. Ott, D. Cox, M M Le Beau, C. Brunn, A. Schinzel, K. Kidd, D. Hewett, A.L. Hillyard, J. Decker, D.N. Cooper, K. Klinger, M. Skolnick, H. Lehrach, M.T. Lott, S. Bryant, P. Simpson, S.H. Laval, Y. Nakamura, D. Louis, S.L. Sherman, M. Tolley, S. Malik, E. Southern, W. Cavenee, Frank H. Collins, S. Mercer, Brien, P. Fain, M. Chipperfield, E. Chang, J.M. Trent, C. Linch, J. Peters, B. Ponder, A. Torroni, A. Bowcock, N. Affara, M. Kaelbling, A.v. Deimling, F. Mitelman, D.P. Doolittle, D.L. Neil, P. Goodfellow, I. Newsham, K. Langley, Gareth Maslen, R.J. Robbins, B. Keats, B.R. Seizinger, A.G. Searle, B.J.B. Keats, P. Pearson, D.T. Bishop, A.-M. Frischauf, J.M. Shoffner, B. Maidak, Judi E. Hewitt, T. Monaco, J.A. Marshall Graves, A. Menon, and C. Coutelle

Subjects
Genetics, Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), Chromosome 12, media_common
Published
1991
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26. Subject Index Vol. 58, 1991

Author

B. Ponder, C. Junien, A. Bowcock, K. Kidd, D.C. Wallace, E. Southern, A. Schinzel, D.N. Cooper, D.T. Bishop, M M Le Beau, S.H. Laval, D.P. Doolittle, I. Newsham, J.M. Shoffner, M.T. Lott, N. Affara, M. Kaelbling, M.T. Davisson, P.A. Lalley, P. Ceverha, Y. Nakamura, B. Maidak, Judi E. Hewitt, W. Cavenee, Y. Kaneko, P. Goodfellow, T. Monaco, J.M. Trent, J.A. Marshall Graves, Brien, S. Naylor, M. Chipperfield, Frank H. Collins, S. Mercer, E. Chang, D.L. Neil, D. Louis, C. Linch, J. Peters, F. Mitelman, P. Pearson, D. Hewett, K. Langley, Christopher J. Rawlings, J. Beckmann, A.v. Deimling, A. Torroni, A.-M. Frischauf, B.J.B. Keats, H. Lehrach, P. Simpson, R.E. Lucier, B. Emanuel, S. Malik, J. Schmidtke, A. Menon, K. Klinger, H.P. Klinger, J. Decker, P. Fain, J. Ott, C. Coutelle, M. Skolnick, M. Tolley, J. Frézal, B.R. Seizinger, A.L. Hillyard, D. Cox, I. Henry, C. Brunn, R. Williamson, Gareth Maslen, R.J. Robbins, B. Keats, A.G. Searle, S.L. Sherman, and S. Bryant

Subjects
Index (economics), Statistics, Genetics, Subject (documents), Biology, Molecular Biology, Genetics (clinical)
Published
1991
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27. Abstractsfor the DNA committee

Author

Christopher J. Rawlings, M.T. Lott, Y. Nakamura, J. Ott, A. Bowcock, H. Lehrach, P. Simpson, K. Klinger, Frank H. Collins, S. Mercer, S. Malik, B. Emanuel, Brien, P.A. Lalley, P. Ceverha, Y. Kaneko, Gareth Maslen, D. Louis, E. Chang, H.P. Klinger, N. Affara, M. Kaelbling, R.J. Robbins, B. Keats, A.G. Searle, S. Bryant, D.L. Neil, S.L. Sherman, A.L. Hillyard, M. Chipperfield, A. Torroni, K. Langley, C. Linch, J. Peters, F. Mitelman, J. Frézal, D.N. Cooper, M.T. Davisson, D.T. Bishop, P. Pearson, D. Hewett, J. Schmidtke, M M Le Beau, I. Henry, S. Naylor, A.-M. Frischauf, J. Decker, D.C. Wallace, D. Cox, A. Schinzel, W. Cavenee, M. Tolley, C. Brunn, M. Skolnick, J.M. Shoffner, B. Maidak, Judi E. Hewitt, T. Monaco, J.A. Marshall Graves, B. Ponder, C. Junien, S.H. Laval, J.M. Trent, P. Goodfellow, D.P. Doolittle, B.J.B. Keats, I. Newsham, A. Menon, C. Coutelle, P. Fain, B.R. Seizinger, R. Williamson, J. Beckmann, R.E. Lucier, K. Kidd, E. Southern, and A.v. Deimling

Subjects
Genetics, chemistry.chemical_compound, chemistry, Biology, Molecular Biology, Genetics (clinical), DNA
Published
1991
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28. Abstracts for the committee on the genetic constitution of chromosome 14

Author

P.A. Lalley, P. Ceverha, Y. Kaneko, A. Menon, A.v. Deimling, C. Junien, J.M. Shoffner, I. Henry, C. Brunn, C. Coutelle, P. Pearson, D.N. Cooper, Gareth Maslen, D.C. Wallace, J. Frézal, F. Mitelman, D. Louis, A.-M. Frischauf, D.L. Neil, A. Schinzel, R.J. Robbins, B. Maidak, M M Le Beau, R. Williamson, Judi E. Hewitt, B. Keats, A.G. Searle, T. Monaco, J.A. Marshall Graves, M.T. Lott, K. Langley, S.L. Sherman, D.P. Doolittle, S. Malik, I. Newsham, Y. Nakamura, S.H. Laval, Christopher J. Rawlings, J. Beckmann, Frank H. Collins, S. Mercer, D. Hewett, R.E. Lucier, J.M. Trent, H. Lehrach, P. Simpson, J. Ott, S. Bryant, P. Fain, K. Kidd, Brien, P. Goodfellow, A. Bowcock, E. Southern, B. Ponder, J. Decker, K. Klinger, D. Cox, B. Emanuel, H.P. Klinger, M. Chipperfield, C. Linch, J. Peters, A.L. Hillyard, B.R. Seizinger, B.J.B. Keats, N. Affara, M. Kaelbling, D.T. Bishop, W. Cavenee, M. Tolley, M.T. Davisson, S. Naylor, E. Chang, A. Torroni, J. Schmidtke, and M. Skolnick

Subjects
Genetics, Chromosome (genetic algorithm), Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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29. Abstracts for the committee on the genetic constitution of chromosome 6

Author

M.T. Davisson, D. Cox, B. Ponder, J.M. Shoffner, S. Naylor, J. Decker, B. Maidak, P.A. Lalley, P. Ceverha, I. Henry, M M Le Beau, Judi E. Hewitt, T. Monaco, K. Klinger, A.L. Hillyard, B.R. Seizinger, D.T. Bishop, M. Tolley, J.A. Marshall Graves, R. Williamson, J.M. Trent, Y. Kaneko, P. Fain, D.L. Neil, D. Hewett, E. Chang, P. Goodfellow, M. Chipperfield, P. Pearson, A. Torroni, K. Langley, M.T. Lott, B.J.B. Keats, C. Junien, C. Linch, J. Peters, Y. Nakamura, N. Affara, M. Kaelbling, W. Cavenee, J. Ott, D.N. Cooper, C. Brunn, F. Mitelman, A. Menon, C. Coutelle, D. Louis, A. Bowcock, S.H. Laval, J. Schmidtke, M. Skolnick, A.-M. Frischauf, Christopher J. Rawlings, H. Lehrach, P. Simpson, Brien, D.C. Wallace, K. Kidd, A. Schinzel, E. Southern, J. Beckmann, R.E. Lucier, D.P. Doolittle, I. Newsham, J. Frézal, S. Malik, Gareth Maslen, B. Emanuel, A.v. Deimling, R.J. Robbins, Frank H. Collins, S. Mercer, B. Keats, A.G. Searle, H.P. Klinger, S. Bryant, and S.L. Sherman

Subjects
Genetics, Chromosome (genetic algorithm), Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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30. Abstracts for the committee on the genetic constitution of chromosome 20

Author

J. Ott, Frank H. Collins, S. Mercer, Gareth Maslen, M.T. Davisson, I. Henry, J. Schmidtke, S. Naylor, B.J.B. Keats, R.J. Robbins, B. Keats, A.G. Searle, M. Skolnick, K. Klinger, N. Affara, M. Kaelbling, M M Le Beau, D.L. Neil, P. Goodfellow, D.C. Wallace, D.P. Doolittle, I. Newsham, K. Langley, C. Junien, J.M. Shoffner, D. Cox, D.N. Cooper, M. Tolley, B. Ponder, B. Maidak, Judi E. Hewitt, D. Hewett, A. Schinzel, T. Monaco, A.L. Hillyard, J.A. Marshall Graves, D.T. Bishop, S.H. Laval, D. Louis, S.L. Sherman, J.M. Trent, B.R. Seizinger, C. Brunn, R. Williamson, P. Fain, S. Bryant, A. Menon, Brien, W. Cavenee, C. Coutelle, E. Chang, A. Torroni, P. Pearson, Christopher J. Rawlings, P.A. Lalley, P. Ceverha, B. Emanuel, A.-M. Frischauf, Y. Kaneko, H.P. Klinger, H. Lehrach, P. Simpson, M.T. Lott, Y. Nakamura, S. Malik, J. Frézal, A.v. Deimling, A. Bowcock, K. Kidd, E. Southern, J. Decker, J. Beckmann, R.E. Lucier, M. Chipperfield, C. Linch, J. Peters, and F. Mitelman

Subjects
Genetics, Constitution, media_common.quotation_subject, Chromosome 20, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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31. Abstracts for the committee on the genetic constitution of chromosome 5

Author

Frank H. Collins, S. Mercer, P. Pearson, D. Cox, B. Emanuel, S. Malik, N. Affara, M. Kaelbling, A.-M. Frischauf, P. Goodfellow, Brien, J. Schmidtke, H.P. Klinger, M. Tolley, M M Le Beau, J. Frézal, S. Bryant, J.M. Shoffner, M.T. Lott, S.L. Sherman, Y. Nakamura, M.T. Davisson, M. Skolnick, D.P. Doolittle, I. Newsham, B. Ponder, D.T. Bishop, R. Williamson, B.R. Seizinger, B. Maidak, A.L. Hillyard, Judi E. Hewitt, T. Monaco, A. Menon, J.A. Marshall Graves, S. Naylor, F. Mitelman, W. Cavenee, D.L. Neil, K. Langley, C. Coutelle, Christopher J. Rawlings, P.A. Lalley, P. Ceverha, E. Chang, D.C. Wallace, K. Klinger, P. Fain, A. Schinzel, B.J.B. Keats, Y. Kaneko, H. Lehrach, P. Simpson, Gareth Maslen, A. Torroni, A.v. Deimling, R.J. Robbins, B. Keats, A.G. Searle, J.M. Trent, C. Brunn, C. Junien, J. Decker, S.H. Laval, A. Bowcock, M. Chipperfield, J. Ott, C. Linch, J. Peters, I. Henry, D. Louis, D.N. Cooper, D. Hewett, K. Kidd, E. Southern, J. Beckmann, and R.E. Lucier

Subjects
Genetics, Chromosome (genetic algorithm), Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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32. Abstracts for the comparative subcommittee on human and mouse homologies

Author

C. Junien, Frank H. Collins, S. Mercer, F. Mitelman, S.H. Laval, R. Williamson, A. Bowcock, D.C. Wallace, J. Schmidtke, D.T. Bishop, P.A. Lalley, P. Ceverha, J.M. Shoffner, A. Schinzel, D. Louis, Y. Kaneko, B. Ponder, B. Maidak, J.M. Trent, B.J.B. Keats, K. Kidd, D. Hewett, J. Decker, Judi E. Hewitt, M. Skolnick, T. Monaco, B. Emanuel, D.P. Doolittle, Gareth Maslen, I. Newsham, J.A. Marshall Graves, D. Cox, A. Menon, M. Chipperfield, D.L. Neil, A.L. Hillyard, P. Goodfellow, H.P. Klinger, M.T. Lott, Y. Nakamura, C. Linch, C. Coutelle, J. Peters, J. Ott, R.J. Robbins, B. Keats, K. Langley, M M Le Beau, A.G. Searle, S.L. Sherman, S. Malik, E. Southern, C. Brunn, I. Henry, B.R. Seizinger, J. Beckmann, R.E. Lucier, S. Bryant, P. Fain, A.v. Deimling, W. Cavenee, J. Frézal, Brien, P. Pearson, A.-M. Frischauf, E. Chang, A. Torroni, D.N. Cooper, M.T. Davisson, Christopher J. Rawlings, S. Naylor, H. Lehrach, P. Simpson, M. Tolley, N. Affara, M. Kaelbling, and K. Klinger

Subjects
Genetics, Evolutionary biology, Biology, Molecular Biology, Genetics (clinical)
Published
1991
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33. Abstracts for the committee on the genetic constitution of chromosome 7

Author

J. Ott, B. Emanuel, E. Chang, M M Le Beau, H.P. Klinger, C. Junien, R. Williamson, K. Klinger, J.M. Trent, Brien, S.H. Laval, A. Torroni, J. Schmidtke, K. Kidd, W. Cavenee, B. Ponder, P. Pearson, D. Cox, N. Affara, M. Kaelbling, D.C. Wallace, M. Tolley, A.-M. Frischauf, D. Hewett, E. Southern, M. Skolnick, Christopher J. Rawlings, A. Bowcock, B.J.B. Keats, D. Louis, J. Beckmann, A. Schinzel, M.T. Lott, Y. Nakamura, C. Brunn, M.T. Davisson, R.E. Lucier, D.N. Cooper, P. Goodfellow, D.T. Bishop, H. Lehrach, P. Simpson, S. Naylor, A. Menon, J. Decker, D.L. Neil, J.M. Shoffner, K. Langley, B. Maidak, Judi E. Hewitt, T. Monaco, M. Chipperfield, J.A. Marshall Graves, C. Coutelle, C. Linch, J. Peters, I. Henry, P. Fain, F. Mitelman, B.R. Seizinger, P.A. Lalley, P. Ceverha, Y. Kaneko, D.P. Doolittle, I. Newsham, Frank H. Collins, S. Mercer, A.L. Hillyard, J. Frézal, A.v. Deimling, S. Malik, S.L. Sherman, S. Bryant, Gareth Maslen, R.J. Robbins, B. Keats, and A.G. Searle

Subjects
Genetics, Chromosome 7 (human), Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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34. Abstracts for the committee on the genetic constitution of the X chromosome (Part 3 of 3)

Author

B. Ponder, M. Tolley, D. Louis, B.J.B. Keats, E. Chang, Christopher J. Rawlings, A. Torroni, M.T. Davisson, D. Hewett, J. Frézal, S. Naylor, D.N. Cooper, P. Fain, J. Ott, A. Menon, Gareth Maslen, D.C. Wallace, P. Goodfellow, D.T. Bishop, R.J. Robbins, B. Keats, C. Coutelle, H. Lehrach, P. Simpson, A.G. Searle, S.L. Sherman, A.L. Hillyard, A. Schinzel, M M Le Beau, M.T. Lott, Y. Nakamura, B.R. Seizinger, N. Affara, M. Kaelbling, K. Kidd, A.v. Deimling, C. Brunn, Brien, S. Bryant, S. Malik, R. Williamson, K. Klinger, P. Pearson, E. Southern, W. Cavenee, D.L. Neil, J. Beckmann, K. Langley, R.E. Lucier, A.-M. Frischauf, J. Schmidtke, M. Skolnick, J. Decker, M. Chipperfield, C. Linch, J. Peters, I. Henry, A. Bowcock, B. Emanuel, J.M. Trent, H.P. Klinger, C. Junien, S.H. Laval, D.P. Doolittle, I. Newsham, Frank H. Collins, S. Mercer, P.A. Lalley, P. Ceverha, Y. Kaneko, J.M. Shoffner, B. Maidak, Judi E. Hewitt, T. Monaco, J.A. Marshall Graves, F. Mitelman, and D. Cox

Subjects
Genetics, Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), X chromosome, media_common
Published
1991
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35. Abstracts for the committee on the genetic constitution of chromosome 10

Author

C. Junien, D. Cox, D.P. Doolittle, D.L. Neil, I. Newsham, Brien, K. Langley, P. Goodfellow, B. Emanuel, A.v. Deimling, J. Beckmann, S.H. Laval, M M Le Beau, C. Brunn, H.P. Klinger, J. Ott, R.E. Lucier, M.T. Lott, S. Malik, B.J.B. Keats, J.M. Shoffner, Y. Nakamura, Christopher J. Rawlings, A. Bowcock, B. Maidak, J. Schmidtke, B. Ponder, Judi E. Hewitt, K. Kidd, T. Monaco, J. Frézal, J.A. Marshall Graves, W. Cavenee, H. Lehrach, P. Simpson, R. Williamson, F. Mitelman, M. Skolnick, D.C. Wallace, M. Tolley, Frank H. Collins, S. Mercer, P. Pearson, A.-M. Frischauf, M.T. Davisson, B.R. Seizinger, A. Schinzel, A.L. Hillyard, J. Decker, E. Southern, P. Fain, D.N. Cooper, A. Menon, D. Louis, I. Henry, S. Naylor, M. Chipperfield, C. Coutelle, E. Chang, C. Linch, J. Peters, A. Torroni, J.M. Trent, P.A. Lalley, P. Ceverha, Y. Kaneko, D.T. Bishop, S. Bryant, Gareth Maslen, D. Hewett, R.J. Robbins, B. Keats, A.G. Searle, S.L. Sherman, K. Klinger, N. Affara, and M. Kaelbling

Subjects
Genetics, Chromosome (genetic algorithm), Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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36. Abstracts for the committee on the genetic constitution of chromosome 19

Author

M.T. Lott, D.L. Neil, Y. Nakamura, K. Langley, Frank H. Collins, S. Mercer, B. Ponder, P. Pearson, A.-M. Frischauf, J. Beckmann, S.L. Sherman, J. Decker, J.M. Trent, R.E. Lucier, J. Schmidtke, Brien, F. Mitelman, D.P. Doolittle, I. Newsham, R. Williamson, M. Skolnick, B.J.B. Keats, W. Cavenee, P.A. Lalley, P. Ceverha, J. Frézal, C. Junien, I. Henry, D.N. Cooper, M. Chipperfield, D.C. Wallace, M. Tolley, Y. Kaneko, C. Linch, J. Peters, Christopher J. Rawlings, N. Affara, P. Fain, Gareth Maslen, B.R. Seizinger, M. Kaelbling, A. Schinzel, J.M. Shoffner, S.H. Laval, A.L. Hillyard, D.T. Bishop, H. Lehrach, P. Goodfellow, A. Menon, B. Maidak, B. Emanuel, P. Simpson, R.J. Robbins, Judi E. Hewitt, T. Monaco, A. Bowcock, B. Keats, A.G. Searle, M.T. Davisson, J.A. Marshall Graves, H.P. Klinger, S. Naylor, C. Coutelle, S. Bryant, A.v. Deimling, E. Chang, A. Torroni, M M Le Beau, S. Malik, K. Klinger, D. Cox, J. Ott, D. Louis, K. Kidd, E. Southern, D. Hewett, and C. Brunn

Subjects
Genetics, Constitution, media_common.quotation_subject, Chromosome 19, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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37. Abstracts for the committee on the genetic constitution of the X chromosome (Part 2 of 3)

Author

D.N. Cooper, D.T. Bishop, B. Ponder, J.M. Trent, P.A. Lalley, P. Ceverha, J. Schmidtke, S. Malik, Y. Kaneko, C. Junien, R. Williamson, C. Brunn, B. Emanuel, P. Goodfellow, M. Skolnick, J. Decker, J. Frézal, M.T. Lott, H.P. Klinger, Y. Nakamura, F. Mitelman, S.H. Laval, M M Le Beau, M. Chipperfield, D. Louis, B.R. Seizinger, M. Tolley, W. Cavenee, A.v. Deimling, C. Linch, B.J.B. Keats, K. Klinger, D.L. Neil, J. Peters, E. Chang, K. Langley, D. Cox, A. Menon, P. Pearson, P. Fain, C. Coutelle, A.L. Hillyard, D. Hewett, J. Ott, A.-M. Frischauf, A. Torroni, J.M. Shoffner, A. Bowcock, B. Maidak, M.T. Davisson, Judi E. Hewitt, T. Monaco, J.A. Marshall Graves, N. Affara, M. Kaelbling, S. Naylor, I. Henry, Christopher J. Rawlings, H. Lehrach, P. Simpson, Brien, Gareth Maslen, D.C. Wallace, R.J. Robbins, B. Keats, A.G. Searle, A. Schinzel, J. Beckmann, R.E. Lucier, S. Bryant, D.P. Doolittle, S.L. Sherman, I. Newsham, K. Kidd, E. Southern, Frank H. Collins, and S. Mercer

Subjects
Genetics, Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), X chromosome, media_common
Published
1991
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38. Abstracts for the committee on the genetic constitution of chromosome 1

Author

B. Emanuel, I. Henry, S.L. Sherman, H.P. Klinger, M.T. Lott, Y. Nakamura, J.M. Shoffner, K. Klinger, B. Maidak, Judi E. Hewitt, T. Monaco, M.T. Davisson, J. Decker, J.A. Marshall Graves, J.M. Trent, D. Hewett, Brien, W. Cavenee, R. Williamson, N. Affara, M. Kaelbling, C. Brunn, B.J.B. Keats, B. Ponder, S. Malik, D.N. Cooper, S. Naylor, P.A. Lalley, P. Ceverha, M. Chipperfield, C. Junien, Christopher J. Rawlings, P. Pearson, C. Linch, Y. Kaneko, J. Peters, D.T. Bishop, D.C. Wallace, A.-M. Frischauf, H. Lehrach, J. Frézal, P. Simpson, M. Tolley, M M Le Beau, F. Mitelman, A. Schinzel, B.R. Seizinger, S. Bryant, D.L. Neil, P. Fain, Frank H. Collins, S. Mercer, A. Bowcock, E. Chang, P. Goodfellow, A. Torroni, K. Langley, S.H. Laval, D.P. Doolittle, I. Newsham, A. Menon, Gareth Maslen, J. Schmidtke, A.v. Deimling, C. Coutelle, M. Skolnick, R.J. Robbins, B. Keats, A.G. Searle, D. Cox, A.L. Hillyard, J. Ott, D. Louis, K. Kidd, E. Southern, J. Beckmann, and R.E. Lucier

Subjects
Genetics, Chromosome (genetic algorithm), Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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39. Abstracts for the committee on the genetic constitution of the Y chromosome

Author

D. Hewett, A.L. Hillyard, D.P. Doolittle, P. Pearson, I. Newsham, J. Frézal, B.J.B. Keats, A.-M. Frischauf, M M Le Beau, M.T. Lott, J.M. Trent, Y. Nakamura, Frank H. Collins, S. Mercer, F. Mitelman, J. Ott, A. Menon, K. Kidd, S. Malik, D.C. Wallace, P. Fain, D.N. Cooper, S. Bryant, C. Coutelle, A. Schinzel, B. Ponder, S.L. Sherman, C. Junien, D. Louis, P.A. Lalley, P. Ceverha, D.T. Bishop, Brien, A.v. Deimling, E. Southern, Y. Kaneko, R. Williamson, B.R. Seizinger, P. Goodfellow, J.M. Shoffner, C. Brunn, B. Maidak, Judi E. Hewitt, S.H. Laval, T. Monaco, J.A. Marshall Graves, J. Beckmann, Gareth Maslen, R.E. Lucier, N. Affara, Christopher J. Rawlings, M. Kaelbling, R.J. Robbins, B. Keats, A.G. Searle, H. Lehrach, P. Simpson, K. Klinger, A. Bowcock, M. Chipperfield, C. Linch, J. Peters, J. Decker, M. Tolley, M.T. Davisson, D. Cox, S. Naylor, D.L. Neil, K. Langley, J. Schmidtke, E. Chang, M. Skolnick, A. Torroni, I. Henry, B. Emanuel, H.P. Klinger, and W. Cavenee

Subjects
Genetics, Constitution, media_common.quotation_subject, Biology, Y chromosome, Molecular Biology, Genetics (clinical), media_common
Published
1991
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40. Abstracts for the committee on the genetic constitution of chromosome 16

Author

S.L. Sherman, B.J.B. Keats, D.N. Cooper, J. Ott, D.P. Doolittle, I. Newsham, A. Menon, F. Mitelman, P. Fain, B. Emanuel, D. Hewett, A.L. Hillyard, N. Affara, M. Kaelbling, H.P. Klinger, C. Junien, D. Louis, C. Coutelle, M. Tolley, D. Cox, Gareth Maslen, D.T. Bishop, Brien, B. Ponder, Frank H. Collins, S. Mercer, C. Brunn, I. Henry, M.T. Davisson, R.J. Robbins, B. Keats, A.G. Searle, B.R. Seizinger, K. Kidd, S. Naylor, M. Chipperfield, P.A. Lalley, P. Ceverha, S. Bryant, E. Chang, M M Le Beau, Christopher J. Rawlings, P. Goodfellow, C. Linch, D.C. Wallace, J. Peters, A. Torroni, E. Southern, Y. Kaneko, R. Williamson, S.H. Laval, J.M. Shoffner, H. Lehrach, P. Simpson, M.T. Lott, B. Maidak, Y. Nakamura, A. Schinzel, Judi E. Hewitt, T. Monaco, J. Beckmann, J.A. Marshall Graves, J.M. Trent, R.E. Lucier, P. Pearson, K. Klinger, A.-M. Frischauf, A. Bowcock, J. Decker, W. Cavenee, J. Schmidtke, M. Skolnick, D.L. Neil, K. Langley, A.v. Deimling, J. Frézal, and S. Malik

Subjects
Genetics, Chromosome 16, Constitution, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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41. Contents Vol. 55, 1990

Author

J. Peters, A. Schinzel, Christopher J. Rawlings, J.L. Mandel, M. Tolley, S. Mercer, B. Byth, M.V. Bell, S. Povey, D. Goudie, N.C. Dracopoli, A. Geurts van Kessel, B.J.B. Keats, I.W. Craig, J. Schmidtke, T. Gedde-Dahl, P. Williamson, C. Junien, E. Solomon, C.J. Rawlings, F. Ricciuti, M. Farrall, S.T. Reeders, M.T Davisson, N.E. Simpson, S.L. Sherman, J. Weissenbach, S. Trumper, D.P. Doolittle, V. Reed, S. Malcolm, D.J. Cockburn, A. Hare, N.K. Spurr, Veronica van Heyningen, D.C. Wallace, R.H.Y. Lam, G.B. van Ommen, A.L. Hillyard, J. Ott, R.L. Nussbaum, J.M. Shoffner, H. Donis-Keller, C.E. Hildebrand, S. Malik, G. Gillett, R. Daniels, F. Mitelman, K.E. Davies, B. Maidak, A.M. Bowcock, J.A. Marshall Graves, P. Pearson, J. Walters, B. Carritt, B.S. Emanuel, T. Doyle, R.E. Lucier, S. Riley, R. Williamson, D. Lindenbaum, Y. Nakamura, J. Borrow, J.M. Trent, T.A. Donlon, C. Jones, A.G. Searle, G.R. Sutherland, L.-C. Tsui, L.C. Stranc, Steve Laval, R.T. Taggart, Sir Walter F. Bodmer, M.T Lott, P. Goodfellow, N. Shimizu, E. Keirnan, Baule, D.T. Bishop, S. Renfrey, M. Leppert, S. Ruddy, M. Barnett, P.J. McAlpine, J.C. Murray, K. Kidd, Y. Kaneko, H.F. Willard, A.P. Monaco, J. Hewitt, Y. Boyd, Z. Chen, H.H. Ropers, H. Cann, C. Boucheix, F. Lewitter, H.S. Chan, S. Ghosh, D.N. Cooper, S.L. Naylor, A. Torroni, C. Porter, G.M. Hampton, C. Westbrook, V. Buckle, M. Chipperfield, T. Morris, M.A. Pericak-Vance, K.H. Grzeschik, J. Frézal, L.L. Field, L. Sefton, W.O. McBride, P.A. Lalley, S.P. Craig, A. Bowcock, R.R. Ali, A. Ziegler, M. Quitt, S.J. O'Brien, D.W. Cox, K. Cooper, M.H. Skolnick, D.R. Cox, M M Le Beau, T.B. Shows, A. Walley, D.H. Ledbetter, K. Gulati, B.R. Seizinger, R. Track, T. Ward, G.A. Bruns, and A.Y. Sakaguchi

Subjects
Botany, Genetics, Zoology, Biology, Molecular Biology, Genetics (clinical)
Published
1990
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42. Report of the committee on chromosome changes in neoplasia

Author

F. Mitelman, Y. Kaneko, J.M. Trent, and S. Mercer

Subjects
Chromosome Aberrations, Genetics, Chromosome Mapping, Aneuploidy, Chromosome, Chromosomal translocation, Biology, medicine.disease, Neoplasms, medicine, Chromosomes, Human, Humans, Trisomy, Molecular Biology, Genetics (clinical)
Published
1990
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43. Evaluation of ABT-751 against childhood cancer models in vivo

Author

Kimberly S Mercer, Claire R. Boltz, Chandra Tucker, Catherine A. Billups, Christopher L. Morton, Edward Favours, Peter J. Houghton, and Jeri Carol Crumpton

Subjects
Childhood cancer, Mice, SCID, Pharmacology, Antimitotic Agents, Pediatrics, Mice, In vivo, Colchicine binding, Cell Line, Tumor, Medicine, Animals, Humans, Pharmacology (medical), Child, Sulfonamides, biology, business.industry, Pediatric Tumor, Phase i trials, Neoplasms, Experimental, Xenograft Model Antitumor Assays, Tubulin, Oncology, Cell culture, biology.protein, Antimitotic Agent, Female, business
Abstract

ABT-751 is a novel antimitotic agent that binds tubulin at the colchicine binding site. ABT-751 is undergoing Phase I trials in children, but has not been evaluated against a range of pediatric tumor models in vivo.ABT-751 was evaluated against 27 subcutaneously implanted xenograft models of childhood cancer including neuroblastoma [4], osteosarcoma [4], Ewing sarcoma [2] rhabdomyosarcoma [8], medulloblastoma [1] and eight kidney cancer lines (six Wilms tumors, two rhabdoid). ABT-751 was administered at 100 mg/kg P.O. on a schedule of 5 days on, 5 days off, 5 days on, repeating the cycle at 21 days. Tumor diameters were measured at 7 day intervals for a period of 12 weeks. Three measures of antitumor activity were used: (1) clinical response criteria [e.g., partial response (PR), complete response (CR), etc.]; (2) treated to control (T/C) tumor volume at day 21; and (3) a time to event measure based on the median event free survival (EFS) of treated and control lines.ABT-751 induced regression in 4 of 25 models (16%) including models of neuroblastoma that are refractory to vincristine and paclitaxel. Other regressions occurred in rhabdomyosarcoma and Wilms tumor models. ABT-751 significantly increased event free survival (EFS2.0) in eight models (33%) in addition to those with objective responses.ABT-751 demonstrated intermediate activity against this tumor panel. Neuroblastoma models appear somewhat more sensitive to this agent, with objective regressions also in rhabdomyosarcoma and Wilms tumor. ABT-751 was also active in several tumor lines intrinsically refractory to vincristine or paclitaxel.

Published
2006

44. Detecting altered postural control after cerebral concussion in athletes with normal postural stability

Author

Vicki S. Mercer, Kevin M. Guskiewicz, James T. Cavanaugh, Nicholas Stergiou, Stephen W. Marshall, and Carol Giuliani

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Posture, Physics::Medical Physics, Physical Therapy, Sports Therapy and Rehabilitation, Approximate entropy, Computer Science::Robotics, Physical medicine and rehabilitation, Concussion, Cerebral concussion, medicine, Postural Balance, Humans, Orthopedics and Sports Medicine, Abnormal Finding, Musculoskeletal Diseases, Brain Concussion, Retrospective Studies, Analysis of Variance, biology, Quantitative Biology::Neurons and Cognition, business.industry, Athletes, General Medicine, medicine.disease, biology.organism_classification, Standard error, Athletic Injuries, Female, Original Article, Analysis of variance, sense organs, business
Abstract

Objective:To determine if approximate entropy (ApEn), a regularity statistic from non-linear dynamics, could detect changes in postural control during quiet standing in athletes with normal postural stability after cerebral concussion.Methods:The study was a retrospective, case series analysis of centre of pressure (COP) data collected during the Sensory Organization Test (SOT) from NCAA Division I (USA) athletes prior to and within 48 h after injury. Subjects were 21 male and six female athletes from a variety of sports who sustained a cerebral concussion between 1997 and 2003. After injury, athletes displayed normal postural stability equivalent to preseason levels. For comparison, COP data also were collected from 15 male and 15 female healthy non-athletes on two occasions. ApEn values were calculated for COP anterior-posterior (AP) and medial-lateral (ML) time series.Results:Compared to healthy subjects, COP oscillations among athletes generally became more regular (lower ApEn value) after injury despite the absence of postural instability. For AP time series, declines in ApEn values were much larger in SOT conditions 1 and 2 (approximately three times as large as the standard error of the mean) than for all other conditions. For ML time series, ApEn values declined after injury in all sensory conditions (F1,55 = 6.36, p = 0.02).Conclusions:Athletes who demonstrated normal postural stability after concussion nonetheless displayed subtle changes in postural control. Changes in ApEn may have represented a clinically abnormal finding. ApEn analysis of COP oscillations may be a valuable supplement to existing concussion assessment protocols for athletes.

Published
2005
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46. Abstracts for the committee on chromosomal changes in neoplasia

Author

D.L. Neil, K. Klinger, P.A. Lalley, P. Ceverha, S. Malik, Brien, Y. Kaneko, J. Ott, B. Emanuel, K. Langley, W. Cavenee, M M Le Beau, R. Williamson, F. Mitelman, D.C. Wallace, C. Junien, A.L. Hillyard, H.P. Klinger, D.P. Doolittle, I. Newsham, A. Schinzel, J. Frézal, J. Schmidtke, S.H. Laval, Christopher J. Rawlings, D.T. Bishop, D. Louis, J. Beckmann, I. Henry, M.T. Lott, Y. Nakamura, J.M. Trent, R.E. Lucier, B.R. Seizinger, M. Skolnick, A. Bowcock, Frank H. Collins, S. Mercer, C. Brunn, N. Affara, M. Kaelbling, H. Lehrach, P. Simpson, K. Kidd, A.v. Deimling, M. Tolley, B.J.B. Keats, D. Cox, E. Southern, E. Chang, A. Menon, A. Torroni, M.T. Davisson, P. Fain, C. Coutelle, S. Naylor, B. Ponder, M. Chipperfield, C. Linch, J. Peters, J.M. Shoffner, J. Decker, P. Goodfellow, B. Maidak, Judi E. Hewitt, T. Monaco, J.A. Marshall Graves, D.N. Cooper, S. Bryant, P. Pearson, Gareth Maslen, D. Hewett, A.-M. Frischauf, R.J. Robbins, B. Keats, A.G. Searle, and S.L. Sherman

Subjects
Genetics, Biology, Bioinformatics, Molecular Biology, Genetics (clinical)
Published
1991
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47. Abstracts for the committee on the genetic constitution of chromosome 18

Author

J.M. Trent, D.N. Cooper, J. Frézal, D.T. Bishop, P. Fain, S. Bryant, A. Menon, S.L. Sherman, C. Junien, P. Goodfellow, D. Louis, M. Tolley, C. Coutelle, N. Affara, P.A. Lalley, P. Ceverha, A.v. Deimling, E. Chang, M. Kaelbling, R. Williamson, A. Torroni, B. Ponder, Y. Kaneko, D.P. Doolittle, M.T. Davisson, S.H. Laval, S. Malik, I. Newsham, B.J.B. Keats, J. Ott, Gareth Maslen, S. Naylor, C. Brunn, W. Cavenee, R.J. Robbins, B. Keats, A.G. Searle, D. Cox, B.R. Seizinger, K. Klinger, F. Mitelman, D. Hewett, D.C. Wallace, M. Chipperfield, P. Pearson, A.L. Hillyard, A. Schinzel, I. Henry, A.-M. Frischauf, C. Linch, J. Peters, Frank H. Collins, S. Mercer, J. Decker, A. Bowcock, J. Schmidtke, B. Emanuel, H.P. Klinger, Brien, M. Skolnick, J. Beckmann, D.L. Neil, R.E. Lucier, K. Langley, Christopher J. Rawlings, M.T. Lott, Y. Nakamura, H. Lehrach, P. Simpson, K. Kidd, E. Southern, J.M. Shoffner, B. Maidak, Judi E. Hewitt, T. Monaco, J.A. Marshall Graves, and M M Le Beau

Subjects
Genetics, Constitution, Chromosome 18, media_common.quotation_subject, Biology, Molecular Biology, Genetics (clinical), media_common
Published
1991
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48. Index of GDB source ID numbers

Author

K. Kidd, Brien, J. Frézal, P. Pearson, E. Southern, F. Mitelman, A.-M. Frischauf, M.T. Davisson, P. Goodfellow, C. Brunn, K. Klinger, D.N. Cooper, J. Beckmann, S.L. Sherman, S. Naylor, D.C. Wallace, A. Schinzel, R.E. Lucier, Christopher J. Rawlings, M M Le Beau, D. Louis, N. Affara, M. Kaelbling, D.T. Bishop, R. Williamson, S. Malik, M. Tolley, A.L. Hillyard, D. Hewett, J.M. Trent, H. Lehrach, B.J.B. Keats, P. Simpson, S. Bryant, Gareth Maslen, E. Chang, P.A. Lalley, P. Ceverha, J. Ott, A. Torroni, R.J. Robbins, B. Keats, A.G. Searle, M.T. Lott, Y. Kaneko, C. Junien, A.v. Deimling, Y. Nakamura, P. Fain, S.H. Laval, I. Henry, J.M. Shoffner, B. Maidak, Judi E. Hewitt, T. Monaco, B. Ponder, J.A. Marshall Graves, B.R. Seizinger, A. Menon, D. Cox, C. Coutelle, W. Cavenee, D.L. Neil, K. Langley, J. Decker, M. Chipperfield, J. Schmidtke, D.P. Doolittle, C. Linch, I. Newsham, J. Peters, M. Skolnick, A. Bowcock, Frank H. Collins, S. Mercer, B. Emanuel, and H.P. Klinger

Subjects
Index (economics), Statistics, Genetics, Biology, Bioinformatics, Molecular Biology, Genetics (clinical)
Published
1991
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49. Abstracts for the committee on the mitochondrial genome

Author

E. Chang, Gareth Maslen, M.T. Lott, Y. Nakamura, D.P. Doolittle, I. Newsham, J. Beckmann, R.E. Lucier, A. Torroni, A. Bowcock, S.H. Laval, K. Kidd, K. Klinger, D. Louis, R.J. Robbins, B. Keats, M.T. Davisson, A.G. Searle, E. Southern, Frank H. Collins, S. Mercer, S.L. Sherman, D.N. Cooper, Brien, J. Decker, S. Naylor, J.M. Trent, N. Affara, M. Kaelbling, D. Hewett, P. Goodfellow, M. Chipperfield, J. Schmidtke, C. Linch, J. Peters, M. Tolley, B.J.B. Keats, P. Pearson, A.L. Hillyard, C. Brunn, A.-M. Frischauf, M M Le Beau, M. Skolnick, S. Bryant, D.L. Neil, J.M. Shoffner, B.R. Seizinger, B. Maidak, K. Langley, Judi E. Hewitt, Christopher J. Rawlings, T. Monaco, A. Menon, I. Henry, J.A. Marshall Graves, A.v. Deimling, P. Fain, D. Cox, C. Coutelle, B. Ponder, H. Lehrach, P. Simpson, J. Ott, D.T. Bishop, S. Malik, J. Frézal, F. Mitelman, P.A. Lalley, P. Ceverha, W. Cavenee, Y. Kaneko, R. Williamson, D.C. Wallace, A. Schinzel, B. Emanuel, H.P. Klinger, and C. Junien

Subjects
Genetics, Mitochondrial DNA, Biology, Molecular Biology, Genetics (clinical)
Published
1991
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50. Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy

Author

Roger S. Mercer, Katherine C. Watt, Charles G. Plopper, Alan R. Buckpitt, Mark J. Kurth, and Dexter Morin

Subjects
Male, Magnetic Resonance Spectroscopy, Cytochrome, Respiratory System, Epoxide, Bronchi, Naphthalenes, Toxicology, Mass spectrometry, Mass Spectrometry, Rats, Sprague-Dawley, chemistry.chemical_compound, Animals, Lung, Chromatography, biology, Chemistry, General Medicine, Nuclear magnetic resonance spectroscopy, Glutathione, Metabolism, Rats, Trachea, Liver, biology.protein, Microsome, Nitro, Carcinogens, Spectrophotometry, Ultraviolet, Injections, Intraperitoneal
Abstract

1-Nitronaphthalene (1-NN) is a mutagenic nitroaromatic which has been detected in emissions from both heavy- and light-duty diesel engines, as well as in urban airborne particles. 1-NN is a cytochrome P450-bioactivated, nonciliated bronchiolar epithelial (Clara) cell cytotoxicant. These studies examined the metabolism of 1-NN to electrophilic metabolites which were trapped as glutathione conjugates in highly susceptible (lung) and less susceptible (liver) tissues of the rat. Significant depletion of reduced glutathione was observed at all levels of tracheobronchial airways of rats treated with 200 mg/kg 1-NN, ip. This observation of depleted glutathione was consistent with the HPLC radioactivity profiles demonstrating six glutathione conjugates isolated from liver and lung microsomal incubations with 1-NN, [(3)H]glutathione, and glutathione S-transferase. Mass spectrometry of all six metabolites in electrospray positive ion mode yielded an ion of m/z 497 (M + H), and daughter ions of m/z 479 (loss of water), m/z 306 (glutathione), and m/z 177 (loss of the nitro group and formation of hydroxy naphthalene thiolate ion), demonstrating the formation of hydroxy-dihydroglutathionyl derivatives presumably via intermediate epoxide(s). Proton nuclear magnetic resonance spectroscopy identified four different regioisomeric conjugates from lung and liver microsomal incubations: 1-nitro-7-glutathionyl-8-hydroxy-7, 8-dihydronaphthalene, 1-nitro-7-hydroxy-8-glutathionyl-7, 8-dihydronaphthalene, 1-nitro-5-hydroxy-6-glutathionyl-5, 6-dihydronaphthalene, and 1-nitro-5-glutathionyl-6-hydroxy-5, 6-dihydronaphthalene. HPLC radioactivity profiles demonstrated that major conjugates generated in the lung were derived from the C(7), C(8)-epoxide, whereas the most prominent metabolites in the liver were derived from the C(5),C(6)-epoxide.

Published
1999

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