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Now days, nanotechnology has emerged as an simple division of current science and untied novel epoch in the fields of material science and receiving the worldwide attention due to its ample applications. The silver nanoparticles (AgNPs) have attracted with considerable interest as a result of their extensive applicability in different research fields such as chemistry, energy, medicine, and catalysis. In the present investigation, we have described a cost effective and eco-friendly technique for the synthesized AgNPs was completed using the aqueous extract of Albizia saman leaf and silver nitrate (1 mM) as a reducing property and also used as a capping agent. AgNPs were characterized using the spectral studies via, UV, FT-IR, XRD, EDX, and HR-SEM analysis. AgNPs were found the size ranging from 30 to 60 nm. AgNPs were also analyzed by ELISA testing method. A silver nanoparticle at different concentrations was evaluated for its antibacterial effect, against various pathogens. The MIC value (minimum...

Plant-mediated synthesis of selenium nanoparticles (Se-NPs) was carried out by a simple precipitation method using the aqueous extract of Diospyros montana. The leaf extract was used as a good capping and stabilizing agent and allowed the formation of stable nanoparticles. These Se-NPs were characterized using UV-Visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction analysis (XRD), transmission electron microscopy (TEM), DLS, zeta potential measurement and elemental analysis by energy-dispersive X-ray spectroscopy (EDX). The FT-IR spectrum confirms the presence of various functional groups in the aqueous leaf extract of Diospyros montana, which may possibly influence the reduction process of the nanoparticles. The XRD data confirmed the formation of crystalline Se-NPs. TEM and DLS analysis determined that the size of the Se-NPs ranges from 4 to 16 nm. The zeta potential obtained was −22.3 mV. The DPPH and the reducing power activity showed the potential antioxidant property of the biosynthesized Se-NPs. The nanoparticle suspension exhibited significant antimicrobial activity against microorganisms such as Gram (+) Staphylococcus aureus, Gram (−) Escherichia coli (bacteria) and Aspergillus niger (fungi). The cytotoxicity of Se-NPs was assayed against human breast-cancer cells (MCF-7). An anticancer property was found in that Se-NPs were able to inhibit the cell growth in a dose-dependent manner.

Recently, green synthesized nanoparticles have been appearing as a most effective activity in antibacterial and anticancer studies probably because of their faster synthesis rate, remarkable biocompatibility and non-toxicity to healthy cells. In the present study, temperature-dependent eco-friendly synthesis of zinc oxide nanoparticles (ZnO NPs) using Sechium edule leaf extract was performed, characterized by spectroscopic techniques, and electron microscopy studies confirm that 400 °C was favorable for the formation of ZnO NPs. The optical absorption spectra (UV–visible spectroscopy) of ZnO NPs appeared as an intense band at 362 nm and transmission electron microscopy results revealed that the spherical-shaped nanoparticles average range was found to be 36.2 nm and the zeta potential was −19.5 mV. Furthermore, compared with chemically synthesized ZnO NPs, the biosynthesized ZnO NPs were significant owing to their photocatalytic activity towards the degradation of reactive blue 160, and they also showed significant cytotoxicity to MCF-7 breast cancer cells (IC50 ~3.5 µg/mL). Finally, biosynthesized ZnO NPs can be used as prospective antibacterial agents on Bacillus subtilis and Klebsiella pneumoniae. Thus, biosynthesized ZnO NPs could potentially be used as an excellent therapeutic agent in the medical field.

Since ancient time, plants serve as a treasure of effective drugs for cancer therapy. In the present study, phytoconstituents and antioxidant activity of Cordia sebestena (C. sebestena) flower in various solvent extracts (hexane, chloroform, acetone, methanol, water) were explored for its biological importance. The total content of phytoconstituents such as phenolic, flavonoid, tannin and nutrient content like carbohydrate, protein are notably observed in acetone extract. Acetone extract has revealed the potent antioxidant property against various free radicals and has good reducing power activity. The biological efficiency of extracts was also evaluated by antibacterial activity against selected human pathogens. The antioxidant effective acetone extract exhibits significant cytotoxic effect on cervical cancer cell line (HeLa). The bioactive compound-hesperetin a flavonoid was isolated from the acetone extract and structure was elucidated by various spectroscopic techniques. Isolated hesperetin compound revealed significantly cytotoxicity for HeLa cell line and its anticancer ability was revalidated by in silico molecular docking study, which exhibited strong interaction with E6 protein of HPV16 cervical carcinoma with significant binding energy.

Nature has been a basis of medicinal agents for thousands of years, and an imposing number of modern drugs have been isolated from natural sources that claim traditional medicinal practice. Albizia saman (F: Fabaceae) is reported to possess multiple medicinal effects. The aim of the present work has been framed with a synergistic goal to explore its antioxidant property through numerous in vitro biochemical assays, estimations and separate to bioactive constituents accountable for its pharmacological properties of Albizia saman seed extracts. Different solvent extracts (n-hexane, ethyl acetate, acetone, methanol) were assessed for the total content of phenol, flavonoid, carbohydrate and protein, in vitro antioxidant assays viz. DPPH, superoxide, hydroxyl radical scavenging assays and ferric reducing power activity. Numerous useful constituents were also identified tentatively using GC-MS analysis. Structural elucidation of the isolated compound was done by spectral techniques such as UV, IR, EI-MS, 1H-NMR and 13C-NMR. The results of the present investigation have pictured its antioxidant property through its phenolic, flavonoid contents and free-radical scavenging assays. Methylated Rhein was exhibited higher antimicrobial activity against Bacillus subtilis (13 mm), Staphylococcus aureus (10 mm), Klebsiella pneumonia (15 mm), Escherichia coli (10 mm), Candida albicans (14 mm) and Alternaria species (15 mm) at the minimum inhibitory concentrations (MIC) 40 µg/mL values. This study terminated that the extracts and isolated compounds had strong antioxidant and moderate antimicrobial activities and could be efficient in the management of oxidative stress related diseases. Practical Applications Albizia saman is a very important medicinal plant, it is used in various ayurvedic preparations. The seed extracts containes the phytoconstituents like flavonoid, phenol, carbohydrate, steroids, terpinoids, proteins, fat and oils. The bioassay-guided fractionation on the seed extracts of Albizia saman has good pharmacological properties, and the interest in the biological activity of the isolated compound shows that it can be used as a chemotherapeutic agent.