1. An Autopsy Case of Primary Biliary Cholangitis with Histological Submassive Hepatic Necrosis Caused by Acute Hepatitis E Virus Infection
- Author
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Takeji Umemura, Yoshinori Sato, Akihiro Ito, Hiroaki Okamoto, Mikiko Kobayashi, Masaharu Takahashi, Ayumi Sugiura, Takayuki Watanabe, Kazuyuki Ono, Satoru Joshita, Tomoo Yamazaki, Yuki Yamashita, and Mizuki Koyama
- Subjects
medicine.medical_specialty ,Cirrhosis ,Necrosis ,Exacerbation ,Bilirubin ,Cholangitis ,Case Report ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Gastroenterology ,Virus ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Hepatitis E virus ,Internal medicine ,Internal Medicine ,medicine ,Humans ,biology ,business.industry ,primary biliary cholangitis ,Liver Cirrhosis, Biliary ,General Medicine ,Jaundice ,Middle Aged ,medicine.disease ,digestive system diseases ,Hepatitis E ,chemistry ,biology.protein ,030211 gastroenterology & hepatology ,Female ,Autopsy ,medicine.symptom ,Antibody ,business ,Massive Hepatic Necrosis - Abstract
A 59-year-old woman who had been diagnosed with cirrhotic primary biliary cholangitis (PBC) 5 years earlier was admitted for severe jaundice (total bilirubin: 30.1 mg/dL). We suspected that her cirrhotic PBC had deteriorated acutely for some reason. Her general condition deteriorated quickly, and she passed away on day 18 of admission. Hepatitis E virus (HEV)-IgA antibodies were positive, and Genotype 3b HEV involvement was confirmed from a blood sample taken on admission. Histopathological findings revealed cirrhosis and submassive loss and necrosis of hepatocytes. Clinicians should consider the possibility of acute HEV infection as a trigger for acute PBC exacerbation.
- Published
- 2021