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Your search keyword '"MESH: Monkeypox"' showing total 3 results
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3 results on '"MESH: Monkeypox"'

1. Intrafamily Transmission of Monkeypox Virus, Central African Republic, 2018

Author

Arnaud Fontanet, Ella Cyrielle Gonofio, Nicolas Berthet, Benjamin Selekon, Xavier Konamna, Antoine Gessain, Emmanuel Nakouné, Camille Besombes, Jean-Claude Manuguerra, Institut Pasteur [Paris] (IP), Institut Pasteur de Bangui, Réseau International des Instituts Pasteur (RIIP), Centre National de la Recherche Scientifique (CNRS), Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), The authors thank Romain Duda for his assistance with identification of the animal species in Aka language. We also acknowledge Rebecca Grant for her relevant suggestion and her kind participation in the formatting of this research letter., Institut Pasteur [Paris], and Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)

Subjects
MESH: Monkeypox, Male, Epidemiology, animal diseases, viruses, lcsh:Medicine, MESH: Central African Republic / epidemiology, Zoonotic disease, West africa, Disease Outbreaks, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Child, MESH: Animals, 030212 general & internal medicine, Orthopoxvirus, MESH: Disease Outbreaks, Monkeypox virus, Child, Central Africa, biology, Transmission (medicine), virus diseases, respiratory system, MESH: Infant, 3. Good health, Central African Republic, Infectious Diseases, Geography, MESH: Young Adult, Child, Preschool, Female, MESH: Zoonoses, MESH: History, 21st Century, Disease transmission, Intrafamily Transmission of Monkeypox Virus, Central African Republic, 2018, Microbiology (medical), Adult, Adolescent, Health Personnel, 030231 tropical medicine, education, History, 21st Century, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Monkeypox, Young Adult, parasitic diseases, medicine, Research Letter, Animals, Humans, lcsh:RC109-216, Family, MESH: Family, MESH: Adolescent, MESH: Humans, lcsh:R, MESH: Child, Preschool, Outbreak, Infant, MESH: Adult, zoonosis, biology.organism_classification, medicine.disease, Virology, MESH: Male, outbreak investigation, zoonoses, MESH: Health Personnel, MESH: Female
Abstract

International audience; Monkeypox is a rare viral zoonotic disease; primary infections are reported from remote forest areas of Central and West Africa. We report an investigation of a monkeypox outbreak in Lobaye, southwest Central African Republic, in October 2018.

Published
2019
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2. Monkeypox virus phylogenetic similarities between a human case detected in Cameroon in 2018 and the 2017-2018 outbreak in Nigeria

Author

Valérie Caro, Elisabeth Carniel, Martial Gide Yonga, Sara Eyangoh, Mathieu Els, Richard Njouom, Christophe Batéjat, Serge Alain Sadeuh-Mba, Alain Georges Etoundi, Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur (RIIP), Ministère de la Santé Publique [Cameroun], Cellule d'Intervention Biologique d'Urgence - Laboratory for Urgent Response to Biological Threats (CIBU), Institut Pasteur [Paris], This work was supported by the Centre Pasteur of Cameroon., We are thankful to the patients or their legal guardians who agreed to be enrolled in this study. We are grateful to Mrs. Gwladys Monamele for English language review., Ministère de la Santé Publique [Yaoundé, Cameroun], and Institut Pasteur [Paris] (IP)

Subjects
0301 basic medicine, MESH: Monkeypox, Male, animal diseases, viruses, Disease Outbreaks, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Child, MESH: Animals, Public Health Surveillance, Cameroon, MESH: Disease Outbreaks, Monkeypox virus, MESH: Phylogeny, Child, Phylogeny, MESH: Middle Aged, Phylogenetic tree, MESH: Public Health Surveillance, MESH: Infant, Newborn, virus diseases, respiratory system, Middle Aged, Infectious Diseases, MESH: Young Adult, Female, MESH: Genome, Viral, West African clade, MESH: Nigeria, Microbiology (medical), Adult, Adolescent, 030106 microbiology, Nigeria, Genome, Viral, Biology, Microbiology, Virus, 03 medical and health sciences, Monkeypox, Young Adult, parasitic diseases, Genetics, medicine, Animals, Humans, Molecular Biology, Ecology, Evolution, Behavior and Systematics, MESH: Adolescent, MESH: Humans, Infant, Newborn, Outbreak, MESH: Adult, MESH: Cameroon, medicine.disease, biology.organism_classification, Virology, MESH: Male, 030104 developmental biology, MESH: Monkeypox virus, Clinical case, Genetic relatedness, Phylogenetic relationships, MESH: Female
Abstract

International audience; A monkeypox virus was detected from a human clinical case in 2018 in Cameroon; a country where no human cases were reported since 1989. The virus exhibited close genetic relatedness with another monkeypox virus isolated in Nigeria during the 2017-2018 outbreak. Although our molecular findings argue in favor of an extension of the monkeypox outbreak from Nigeria into Cameroon, the possibility that the monkeypox virus detected could be indigenous to Cameroon cannot be ruled out.

Published
2018
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3. Subunit recombinant vaccine protects against monkeypox

Author

Christopher Trindade, Jay W. Hooper, Aysegul Nalca, Peter Silvera, Genoveffa Franchini, Jean-Michel Heraud, Vaniambadi S. Kalyanaraman, Victor I. Ayala, Irene Kalisz, David Venzon, Barney S. Graham, Wen-Po Tsai, Anna Hryniewicz, Monica Vaccari, Mike Bray, Yvette Edghill-Smith, Meredith Hassett, Jody Manischewitz, Hana Golding, Lisa R. King, Janie Parrino, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Advanced Bioscience Laboratories (ABL), National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), U.S. Food and Drug Administration (FDA), University of Bialystok, U.S. Army Medical Research Institute of Infectious Diseases, Southern Research Institute [Birmingham, USA], This work was supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research, the National Institute of Allergy and Infectious Diseases Intramural Biodefense Research Award program, and and National Institutes of Health Contract N01-AI-15451.

Subjects
MESH: Monkeypox, viruses, MESH: Vaccines, Subunit, MESH: Amino Acid Sequence, Antibodies, Viral, law.invention, Dryvax, chemistry.chemical_compound, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, law, Immunology and Allergy, MESH: Animals, Monkeypox virus, Smallpox vaccine, Antigens, Viral, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, 0303 health sciences, Vaccines, Synthetic, virus diseases, 3. Good health, Titer, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Vaccines, Subunit, Recombinant DNA, [SDV.IMM]Life Sciences [q-bio]/Immunology, MESH: Antigens, Viral, Smallpox Vaccine, MESH: Vaccines, Synthetic, Immunology, Molecular Sequence Data, Biology, Virus, MESH: Macaca mulatta, 03 medical and health sciences, Monkeypox, MESH: Viral Vaccines, medicine, Smallpox, Animals, Amino Acid Sequence, 030304 developmental biology, MESH: Molecular Sequence Data, 030306 microbiology, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Viral Vaccines, medicine.disease, MESH: Smallpox Vaccine, Virology, Macaca mulatta, MESH: DNA, Viral, Disease Models, Animal, MESH: Monkeypox virus, chemistry, DNA, Viral, MESH: Disease Models, Animal, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology, Vaccinia, MESH: Antibodies, Viral
Abstract

The smallpox vaccine Dryvax, a live vaccinia virus (VACV), protects against smallpox and monkeypox, but is contraindicated in immunocompromised individuals. Because Abs to VACV mediate protection, a live virus vaccine could be substituted by a safe subunit protein-based vaccine able to induce a protective Ab response. We immunized rhesus macaques with plasmid DNA encoding the monkeypox orthologs of the VACV L1R, A27L, A33R, and B5R proteins by the intradermal and i.m. routes, either alone or in combination with the equivalent recombinant proteins produced in Escherichia coli. Animals that received only DNA failed to produce high titer Abs, developed innumerable skin lesions after challenge, and died in a manner similar to placebo controls. By contrast, the animals vaccinated with proteins developed moderate to severe disease (20–155 skin lesions) but survived. Importantly, those immunized with DNA and boosted with proteins had mild disease with 15 or fewer lesions that resolved within days. DNA/protein immunization elicited Th responses and binding Ab titers to all four proteins that correlated negatively with the total lesion number. The sera of the immunized macaques recognized a limited number of linear B cell epitopes that are highly conserved among orthopoxviruses. Their identification may guide future efforts to develop simpler, safer, and more effective vaccines for monkeypox and smallpox.

Published
2006
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