1. Chinese herb microneedle patch for wound healing
- Author
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Lijun Cai, Junjie Chi, Lingyu Sun, Changmin Shao, Lu Fan, Yuanjin Zhao, and Luoran Shang
- Subjects
food.ingredient ,Premna microphylla ,QH301-705.5 ,0206 medical engineering ,Biomedical Engineering ,Wound healing ,02 engineering and technology ,Traditional Chinese medicine ,Biology ,Asiatic acid ,complex mixtures ,Article ,Biomaterials ,Disease therapy ,food ,ASIATIC ACID ,Biology (General) ,Materials of engineering and construction. Mechanics of materials ,Centella ,Traditional medicine ,Microneedle ,Chinese herbs ,021001 nanoscience & nanotechnology ,biology.organism_classification ,020601 biomedical engineering ,Herb ,TA401-492 ,Chinese herb ,Patch ,0210 nano-technology ,Biotechnology - Abstract
Traditional Chinese medicine and Chinese herbs have a demonstrated value for disease therapy and sub-health improvement. Attempts in this area tend to develop new forms to make their applications more convenient and wider. Here, we propose a novel Chinese herb microneedle (CHMN) patch by integrating the herbal extracts, Premna microphylla and Centella asiatica, with microstructure of microneedle for wound healing. Such path is composed of sap extracted from the herbal leaves via traditional kneading method and solidified by plant ash derived from the brine induced process of tofu in a well-designed mold. Because the leaves of the Premna microphylla are rich in pectin and various amino acids, the CHMN could be imparted with medicinal efficacy of heat clearing, detoxicating, detumescence and hemostatic. Besides, with the excellent pharmaceutical activity of Asiatic acid extracted from Centella asiatica, the CHMN is potential in promoting relevant growth factor genes expression in fibroblasts and showing excellent performance in anti-oxidant, anti-inflammatory and anti-bacterial activity. Taking advantages of these pure herbal compositions, we have demonstrated that the derived CHMN was with dramatical achievement in anti-bacteria, inhibiting inflammatory, collagen deposition, angiogenesis and tissue reconstruction during the wound closure. These results indicate that the integration of traditional Chinese herbs with progressive technologies will facilitate the development and promotion of traditional Chinese medicine in modern society., Graphical abstract Image 1, Highlights • A microneedle patch composed of pure Chinese herb. • Solidification of the patch derived from the brine induced process of tofu. • Effective constituents of the herbs imparting the patch with pharmaceutical activity. • Chinese herb microneedle patch promoting wound healing.
- Published
- 2021