1. Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice
- Author
-
Anna M. Barron, Yingrou Tan, Dehua Liu, Christiane Ruedl, Qi Chen, Lai Guan Ng, Si Min Lai, Shu Zhen Chong, Roshan R. Naik, Shaohai Xu, Sunil S Adav, Jia Chi Tan, Jinmiao Chen, Keith Weng Kit Leong, School of Biological Sciences, Lee Kong Chian School of Medicine (LKCMedicine), and Singapore Phenome Centre
- Subjects
Adipose Tissue, White ,Adipose tissue macrophages ,Transgene ,Immunology ,Adipocyte Hypertrophy ,Mice, Obese ,obesity‐mediated adipose tissue remodeling ,Adipose tissue ,White adipose tissue ,Biology ,Biochemistry ,Article ,Extracellular matrix ,Mice ,chemistry.chemical_compound ,adipocyte hypertrophy ,Fibrosis ,Adipocyte ,Genetics ,medicine ,Animals ,Molecular Biology ,Macrophages ,fibrosis ,Biological sciences [Science] ,nutritional and metabolic diseases ,food and beverages ,vascular integrity ,Articles ,medicine.disease ,tissue‐resident macrophages ,Cell biology ,Mice, Inbred C57BL ,Metabolism ,Adipose Tissue ,chemistry ,lipids (amino acids, peptides, and proteins) ,Adipocyte hypertrophy ,hormones, hormone substitutes, and hormone antagonists - Abstract
Tissue‐resident macrophages in white adipose tissue (WAT) dynamically adapt to the metabolic changes of their microenvironment that are often induced by excess energy intake. Currently, the exact contribution of these macrophages in obesity‐driven WAT remodeling remains controversial. Here, using a transgenic CD169‐DTR mouse strain, we provide new insights into the interplay between CD169+ adipose tissue macrophages (ATMs) and their surrounding WAT microenvironment. Using targeted in vivo ATM ablation followed by transcriptional and metabolic WAT profiling, we found that ATMs protect WAT from the excessive pathological remodeling that occurs during obesity. As obesity progresses, ATMs control not only vascular integrity, adipocyte function, and lipid and metabolic derangements but also extracellular matrix accumulation and resultant fibrosis in the WAT. The protective role of ATMs during obesity‐driven WAT dysfunction supports the notion that ATMs represent friends, rather than foes, as has previously assumed., This study reveals that resident macrophages in the adipose tissue are important regulatory cells that restrain tissue dysregulation caused by obesity.
- Published
- 2021