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5 results on '"Hadrien Lalagüe"'

1. An Integrated Proteomic and Transcriptomic Analysis Reveals the Venom Complexity of the Bullet Ant Paraponera clavata

Author

Samuel D. Robinson, Pierre Escoubas, Graham M. Nicholson, Regan J. Hayward, Sandy S. Pineda, Samira R. Aili, Axel Touchard, Garry S. A. Myers, Matthew P. Padula, R. Manjunatha Kini, Hadrien Lalagüe, Mrinalini, Eivind A. B. Undheim, Irina Vetter, Ecologie des forêts de Guyane (UMR ECOFOG), and Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-AgroParisTech-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Proteomics, Proteome, Health, Toxicology and Mutagenesis, lcsh:Medicine, Hyaluronidase, Shotgun, Venom, Peptide, Toxicology, Tandem mass spectrometry, Paraponera clavata, Tandem Mass Spectrometry, Ganglia, Spinal, Databases, Genetic, DRG neurons, Cells, Cultured, Chromatography, High Pressure Liquid, chemistry.chemical_classification, 0303 health sciences, Chromatography, Reverse-Phase, 030302 biochemistry & molecular biology, 0601 Biochemistry and Cell Biology, 1115 Pharmacology and Pharmaceutical Sciences, Paraponeritoxin, 3. Good health, Phospholipases, [SDE]Environmental Sciences, Insect Proteins, neurotoxins, Computational biology, Biology, Ant venom, complex mixtures, Article, 03 medical and health sciences, medicine, Animals, 030304 developmental biology, Sequence database, Ant Venoms, Ants, Gene Expression Profiling, lcsh:R, Eurotoxins, medicine.disease, biology.organism_classification, Mice, Inbred C57BL, chemistry, RP-HPLC, Calcium, Transcriptome, Function (biology)
Abstract

A critical hurdle in ant venom proteomic investigations is the lack of databases to comprehensively and specifically identify the sequence and function of venom proteins and peptides. To resolve this, we used venom gland transcriptomics to generate a sequence database that was used to assign the tandem mass spectrometry (MS) fragmentation spectra of venom peptides and proteins to specific transcripts. This was performed alongside a shotgun liquid chromatography&ndash, mass spectrometry (LC-MS/MS) analysis of the venom to confirm that these assigned transcripts were expressed as proteins. Through the combined transcriptomic and proteomic investigation of Paraponera clavata venom, we identified four times the number of proteins previously identified using 2D-PAGE alone. In addition to this, by mining the transcriptomic data, we identified several novel peptide sequences for future pharmacological investigations, some of which conform with inhibitor cysteine knot motifs. These types of peptides have the potential to be developed into pharmaceutical or bioinsecticide peptides.

Published
2020
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2. Aquarium trade and fish farms as a source of non-native freshwater fish introductions in French Guiana

Author

Sébastien Brosse, Grégory Quartarollo, Antoine Baglan, Hadrien Lalagüe, Régis Vigouroux, Raphaël Covain, Pierre-Yves Le Bail, Evolution et Diversité Biologique (EDB), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Guyane Wild Fish Association (GWF), Museum d'Histoire Naturelle [Genève] (MHN), Département d'herpétologie et d'ichtyologie, route de Malagnou 1, CP 6434, Muséum d'Histoire Naturelle de Genève, Ecologie des forêts de Guyane (UMR ECOFOG), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-AgroParisTech-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire de Physiologie et Génomique des Poissons (LPGP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This work has been supported by theLABEX CEBA (ANR-10-LABX-25-01) and TULIP (ANR10-LABX-41), Investissement d’Avenir grants of the FrenchAgence Nationale de la Recherche, as well as by the DGTMand Office de l’Eau Guyane (IQCN project)., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), ANR-10-LABX-0041,TULIP,Towards a Unified theory of biotic Interactions: the roLe of environmental(2010), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0106 biological sciences, Neotropics, river, [SDV]Life Sciences [q-bio], Fish farming, ved/biology.organism_classification_rank.species, Hyphessobrycon eques, Aquatic Science, invasion pathways, 010603 evolutionary biology, 01 natural sciences, 14. Life underwater, Biological invasions, propagule pressure, Pterophyllum scalare, biology, ved/biology, 010604 marine biology & hydrobiology, Cichla monoculus, South America, biology.organism_classification, Fishery, Osteoglossum bicirrhosum, Heros efasciatus, Freshwater fish, Arapaima gigas
Abstract

Rivers of French Guiana are still little invaded by non-native fish, but several fish introductions were recently recorded through the development of aquarium fish trade and fish farms. Here we report records of 11 non-native fish species. Among them, four (Cichla monoculus, Heros efasciatus, Mesonauta guyanae and Poecilia reticulata) are established and one of them (Heros efasciatus) is rapidly increasing its spatial range. Two species (Hyphessobrycon eques and Pterophyllum scalare) were not retrieved in recent records and are probably extinct from French Guiana. The establishment status of the five other species (Arapaima gigas, Colossoma macropomum, Cyprinus carpio, Oreochromis mossambicus and Osteoglossum bicirrhosum) is uncertain and only a few specimens were observed in the wild. Nevertheless, these species, intensively reared in nearby countries, belong to highly invasive species able to cause detrimental impacts on recipient ecosystems. Those first occurrences of invasive fish species in French Guiana should therefore act as an early warning for both researchers and environmental managers.

Published
2021
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3. Genome-environment association study suggests local adaptation to climate at the regional scale in[i] Fagus sylvatica[/i]

Author

Andrea R. Pluess, Caroline Heiri, Aline Frank, Hadrien Lalagüe, Giovanni G. Vendramin, Sylvie Oddou-Muratorio, Swiss Federal Institute for Forest, Snow and Landscape Research WSL, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Institute of Biosciences and Bioresources, Consiglio Nazionale delle Ricerche [Roma] (CNR), Unité de Recherches Forestières Méditerranéennes (URFM), Institut National de la Recherche Agronomique (INRA), Financial support was provided by 'Fonds zur Forderung forstlicher Forschung, ETH' and the research programme 'Forest and climate change' funded by the Federal Office for the Environment FOEN and WSL. G.G.V. was supported by a grant from the European Commission through the FP7-project FORGER (KBBE-289119), Swiss Federal Institute for Forest, Snow and Avalanche Research WSL, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Ecologie des forêts de Guyane (UMR ECOFOG), and Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-AgroParisTech-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)

Subjects
0106 biological sciences, 0301 basic medicine, Candidate gene, Physiology, Climate, Genomics, Plant Science, adaptation, Biology, Genes, Plant, 010603 evolutionary biology, 01 natural sciences, Polymorphism, Single Nucleotide, Gene flow, 03 medical and health sciences, landscape genomics, Gene Frequency, Fagus, Selection, Genetic, local persistence, isolation by distance/environment (IBD/IBE), Isolation by distance, Local adaptation, Geography, Ecology, Microevolution, fagus sylvatica (European beech), Adaptation, Physiological, Genome-environment association (GEA), microevolution, 030104 developmental biology, climate change, 13. Climate action, Evolutionary biology, Genetic structure, genome–environment association (GEA), Gene-Environment Interaction, Adaptation, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Genome, Plant, Switzerland
Abstract

The evolutionary potential of long-lived species, such as forest trees, is fundamental for their local persistence under climate change (CC). Genome–environment association (GEA) analyses reveal if species in heterogeneous environments at the regional scale are under differential selection resulting in populations with potential preadaptation to CC within this area. In 79 natural [i]Fagus sylvatica[/i] populations, neutral genetic patterns were characterized using 12 simple sequence repeat (SSR) markers, and genomic variation (144 single nucleotide polymorphisms (SNPs) out of 52 candidate genes) was related to 87 environmental predictors in the latent factor mixed model, logistic regressions and isolation by distance/environmental (IBD/IBE) tests. SSR diversity revealed relatedness at up to 150m intertree distance but an absence of large-scale spatial genetic structure and IBE. In the GEA analyses, 16 SNPs in 10 genes responded to one or several environmental predictors and IBE, corrected for IBD, was confirmed. The GEA often reflected the proposed gene functions, including indications for adaptation to water availability and temperature. Genomic divergence and the lack of large-scale neutral genetic patterns suggest that gene flow allows the spread of advantageous alleles in adaptive genes. Thereby, adaptation processes are likely to take place in species occurring in heterogeneous environments, which might reduce their regional extinction risk under CC

Published
2016
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4. The discovery of devil's gardens: an ant–plant mutualism in the cloud forests of the Eastern Amazon

Author

Stanislas Talaga, Alex Salas-Lopez, Hadrien Lalagüe, Ecologie des forêts de Guyane (UMR ECOFOG), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-AgroParisTech-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), ANR : CEBA 10 LABX 2501, and Université des Antilles (UA)-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-AgroParisTech-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)

Subjects
0106 biological sciences, 010504 meteorology & atmospheric sciences, Biogeography, Amazonian, mutualism, [SDV]Life Sciences [q-bio], biogeographie, 010603 evolutionary biology, 01 natural sciences, cloud forest, Myrmecophyte, Forest ecology, Myrmelachista, refuge hypothesis, forest ecology, Ecology, Evolution, Behavior and Systematics, biogeography, 0105 earth and related environmental sciences, Cloud forest, Mutualism (biology), biology, Amazon rainforest, Ecology, 15. Life on land, biology.organism_classification, écologie forestière, Geography, Cordia nodosa, ant-plant interactions
Abstract

Devil's gardens are one of the most remarkable mutualistic associations between ants and plants. Myrmelachista ants eliminate all vegetation from around their host plants, resulting in wide forest clearings which have intrigued scientists from the start. Despite their noticeability, here we report the discovery of devil's gardens in remote highland cloud forests of the Eastern Amazon, more than 2000 km away from their nearest known analogues in Western Amazonia. We describe the ecological characteristics of these gardens and consider what factors could have produced the geographic isolation of Eastern Amazonian devil's gardens. Three hypotheses are investigated: (1) the host plant distribution restricts the distribution of the mutualism, (2) the ecological tolerances of Myrmelachista explain the isolation, and (3) the devil's gardens of the Eastern Amazon constitute relicts from ancient forest refugia. The distribution of the possible associated myrmecophytes and previously described ecological ranges of devil's gardens cannot explain their ecological restriction to cloud forests in Eastern Amazonia, but our discovery is consistent with the biogeographic refuge hypothesis (i.e. highlands along the Amazon Basin constitute refugia for humid forests that spread during the Cenozoic). Our finding opens exciting perspectives for comparative studies of the origin, ecology and evolutionary history of this ant–plant mutualism.

Published
2016
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5. Fifty years of genetic studies what to make of the large amounts of variation found within populations?

Author

Santiago C. González-Martínez, Ivan Scotti, Hadrien Lalagüe, Katharina B. Budde, Ecologie des Forêts Méditerranéennes (URFM), Institut National de la Recherche Agronomique (INRA), Centro de Investigacion Forestal (INIA-CIFOR), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (INIA), Department of Geosciences and Natural Resource Management [Copenhagen] (IGN), Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Ecologie des forêts de Guyane (UMR ECOFOG), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-AgroParisTech-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), This work was funded by the ANR-12-ADAP-0007 'FLAG' grant., ANR-12-ADAP-0007,FLAG,Génétique écologique des arbres forestiers : interactions entre flux de gènes et variabilité environnementale dans la détermination de l'adaptation locale et du potentiel d'adaptation(2012), and This work was funded by the ANR-12-ADAP-0007-01 'FLAG' grant

Subjects
0106 biological sciences, 0301 basic medicine, arbre forestier, pinus, Natural selection, [SDV]Life Sciences [q-bio], Forest management, Microgeography, Population genomics, Intra-specific, variation, Biotechnologies, Biology, 010603 evolutionary biology, 01 natural sciences, betula pendula, 03 medical and health sciences, Intra-specific variation, génomique des populations, ComputingMilieux_MISCELLANEOUS, diversité phénotypique, Ecology, sciences forestières, eperua, Forestry, variabilité géographique, variation intraspécifique, 030104 developmental biology, Variation (linguistics), Evolutionary biology, picea, diversité génétique, étude génétique, fagus, sélection naturelle
Abstract

International audience; No abstract available

Published
2016
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