1. Claes Hellerström and Cartesian diver microrespirometry.
- Author
-
Welsh M
- Subjects
- Adenosine Triphosphate chemistry, Animals, Diabetes Mellitus, Type 2 metabolism, Glucose metabolism, Glycolysis, History, 20th Century, Insulin metabolism, Insulin Secretion, Insulin-Secreting Cells cytology, Insulin-Secreting Cells metabolism, Islets of Langerhans pathology, Mice, Models, Biological, Oxygen metabolism, Sweden, Universities, Biology history, Islets of Langerhans physiology, Oxygen Consumption
- Abstract
Cartesian diver microrespirometry was introduced by Claes Hellerström at the Department of Histology/Medical Cell Biology at Uppsala University, Sweden, to determine rates of oxygen consumption in islets of Langerhans. The theory behind this method is touched upon and the main findings described. Glucose-stimulated beta cell respiration significantly contributes to increased ATP generation, which is a prerequisite for stimulated insulin secretion and synthesis. This has had major implications for understanding the beta cell stimulus-secretion coupling.
- Published
- 2016
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