1. Two new friedelane lactones from the roots of Caloncoba glauca (Flacourtiaceae) and evaluation of their cardiotonic activity on isolated frog & rsquo;s heart
- Author
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Jean Duplex Wansi, Emmanuel Albert Mpondo Mpondo, Jean Claude Ndom, Moise Henri Julien Nko’o, David Emery Tsala, Flavien A. A. Toze, Cédric Guy Tchatchouang Noulala, Norbert Sewald, and Francois Eya’ane Meva
- Subjects
Chronotropic ,biology ,010405 organic chemistry ,Chemistry ,Stereochemistry ,Calcium channel ,activity ,Plant Science ,biology.organism_classification ,Cardiotonic ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Triterpenoid ,Flacourtiaceae ,Friedelane-lactone ,Receptor ,Caloncoba glauca ,Agronomy and Crop Science ,Two-dimensional nuclear magnetic resonance spectroscopy ,Direct stimulation ,Biotechnology - Abstract
Two new friedelane triterpenoids, 20,20-dimethyl-3,27-dioxo-(D:A)-friedo-olean-27,22α-lactone (20,20-dimethylglaucalactone) (1) and 3α-ethanoyloxy-30-nor-(D:A)- friedo-olean-20(29)-en-27,22α-lactone (3-acetoxyglaucalactone) (2) and four known compounds (3–6) were isolated from the methanolic extract of the roots of Caloncoba glauca (P. Beauv.) Gild (Flacourtiaceae). Their structures were determined by comprehensive spectroscopic analyses (1D and 2D NMR in addition to HRESI-MS). The relative configuration of the 22-oxymethine was determined from the NOESY spectrum. The cardiotonic effects of the crude extract and isolated compounds were tested. The results suggest that the crude extract and 3-acetoxyglaucalactone (2) induced an interesting cardiotonic activity by exerting positive inotropic and chronotropic effects, which might be derived from the direct stimulation of the β-adrenergic pathway through β1-adrenergic receptors or opening of the calcium channel.
- Published
- 2021
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