1. Unique roles of ATAC and SAGA - KAT2A complexes in normal and malignant hematopoiesis
- Author
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Svenja Kleinwaechter, Ana Filipa Domingues, Liliana Arede, Rashmi Kulkarni, Laszlo Tora, Shikha Gupta, Elena Foerner, Elisabeth Scheer, Cristina Pina, Selinde Wind, Department of Haematology, University of Cambridge [UK] (CAM), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), and Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
0303 health sciences ,biology ,[SDV]Life Sciences [q-bio] ,030302 biochemistry & molecular biology ,Regulator ,Context (language use) ,Histone acetyltransferase ,medicine.disease ,Cell biology ,03 medical and health sciences ,Leukemia ,Haematopoiesis ,Histone ,biology.protein ,medicine ,Epigenetics ,Progenitor cell ,030304 developmental biology - Abstract
Epigenetic histone modifiers are key players in cell fate decisions. Significant research has focused on their enzymatic activity, but less is known about the contextual role of the complexes they integrate. We focus on KAT2A, a histone acetyltransferase we recently associated with leukemia stem cell maintenance, and which participates in ATAC and SAGA complexes. We show that ATAC is uniquely required for maintenance of normal and leukemia stem and progenitor cells, while SAGA more specifically contributes to cell identity. This dichotomy sets a paradigm for investigating epigenetic activities in their macromolecular context and informs epigenetic regulator targeting for translational purposes.
- Published
- 2021