5 results on '"Dragana Mijatović"'
Search Results
2. Tick-Borne Encephalitis Virus Seropositivity among Tick Infested Individuals in Serbia
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Pavle Banović, Adrian Alberto Díaz-Sánchez, Vesna Turkulov, Dragana Mijatović, Jasmina Grujic, Alejandro Cabezas-Cruz, Zorana Budakov-Obradovic, Dasiel Obregón, Nevenka Bujandric, Sinisa Sević, Srdjan Stankov, Verica Simin, Pasteur Institute Novi Sad, University of Novi Sad, School of Environmental Sciences, University of Guelph, Federal University of Sao Paulo (Unifesp), Blood Transfusion Institute Vojvodina, Clinical Center of Vojvodina, University of Saskatchewan - Department of Biology, University of Saskatchewan [Saskatoon] (U of S), Biologie moléculaire et immunologie parasitaires et fongiques (BIPAR), École nationale vétérinaire - Alfort (ENVA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Pasteur de Serbie, Réseau International des Instituts Pasteur (RIIP), and École nationale vétérinaire d'Alfort (ENVA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé
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Microbiology (medical) ,medicine.medical_specialty ,Population ,lcsh:Medicine ,Tick ,Article ,Serology ,03 medical and health sciences ,TBEV ,Epidemiology ,parasitic diseases ,medicine ,Immunology and Allergy ,Seroprevalence ,risk factors ,education ,Molecular Biology ,Direct fluorescent antibody ,030304 developmental biology ,0303 health sciences ,education.field_of_study ,General Immunology and Microbiology ,biology ,seroprevalence ,030306 microbiology ,business.industry ,lcsh:R ,biology.organism_classification ,medicine.disease ,3. Good health ,Tick-borne encephalitis virus ,Infectious Diseases ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Immunology ,business ,Encephalitis - Abstract
Tick-borne encephalitis (TBE), caused by the TBE virus (TBEV), is a life-threatening disease with clinical symptoms ranging from non-specific to severe inflammation of the central nervous system. Despite TBE is a notifiable disease in Serbia since 2004, there is no active TBE surveillance program for the serologic or molecular screening of TBEV infection in humans in the country. This prospective cohort study aimed to assess the TBEV exposure among tick-infested individuals in Serbia during the year 2020. A total of 113 individuals exposed to tick bites were recruited for the study and screened for anti-TBEV antibodies using a commercial indirect fluorescent antibody test (IFA) test. Blood samples from 50 healthy donors not exposed to tick bites were included as a control group. Most of the enrolled patients reported infestations with one tick, being I. ricinus the most frequent tick found in the participants. The TBEV seroprevalence was higher (13.27%, 15 total 113) in tick-infested individuals than in healthy donors (4%, 2 total 50), although the difference was not significant. Notably, male individuals exposed to tick bites showed five times higher relative risk (RR) of being TBEV-seropositive than healthy donors of the same gender (RR= 5.1, CI = 1.6–19, p = 0.007). None of the seropositive individuals developed clinical manifestations of TBE, but the first clinical-stage of Lyme borreliosis (i.e., erythema migrans) was detected in seven of them. Potential TBEV foci were identified in rural areas, mostly in proximity or within the Fruška Gora mountain. We conclude that the Serbian population is at high risk of TBEV exposure. Further epidemiological studies should focus on potential TBEV foci identified in this study. The implementation of active surveillance for TBEV might contribute to evaluating the potential negative impact of TBE in Serbia.
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- 2021
3. Shared Odds of Borrelia and Rabies Virus Exposure in Serbia
- Author
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Abdul Jabbar, Pavle Banović, Adrian Alberto Díaz-Sánchez, Verica Simin, Nenad Vranješ, Dragana Vujin, Alejandro Cabezas-Cruz, Abdul Ghafar, Dragana Mijatović, Dasiel Obregón, Nevenka Bujandric, Zorana Budakov-Obradovic, Zsolt Horváth, Jasmina Grujic, Pasteur Institute Novi Sad, University of Novi Sad, University of Saskatchewan [Saskatoon] (U of S), Agricultural School, Blood Transfusion Institute Vojvodina, Faculty of Veterinary and Agricultural Science [Melbourne], University of Melbourne, School of Environmental Sciences, University of Guelph, University of São Paulo (USP), Biologie moléculaire et immunologie parasitaires et fongiques (BIPAR), École nationale vétérinaire - Alfort (ENVA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur de Serbie, Réseau International des Instituts Pasteur (RIIP), and École nationale vétérinaire d'Alfort (ENVA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé
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Microbiology (medical) ,medicine.medical_specialty ,relative odds ,education ,lcsh:Medicine ,rabies ,medicine.disease_cause ,Article ,03 medical and health sciences ,0302 clinical medicine ,Lyme disease ,Internal medicine ,Borrelia ,medicine ,Immunology and Allergy ,Seroprevalence ,030212 general & internal medicine ,Molecular Biology ,0303 health sciences ,General Immunology and Microbiology ,biology ,seroprevalence ,030306 microbiology ,business.industry ,Rabies virus ,Zoonosis ,lcsh:R ,Tick-borne encephalitis ,Odds ratio ,medicine.disease ,biology.organism_classification ,3. Good health ,Infectious Diseases ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,exposure ,Rabies ,business ,Shared rabies - Abstract
Lyme borreliosis (LB) is the most common tick-borne disease in Serbia and other European countries. Rabies is a fatal zoonosis distributed worldwide and is caused by the rabies virus. Professionals at risk of rabies—including veterinarians, hunters, communal service workers, and forestry workers—overlap with some professions at a higher risk of exposure to tick bites and tick-borne pathogen infections. We hypothesized that individuals identified by the public health system as at risk of rabies virus infection, and consequently vaccinated against rabies virus, also share a higher likelihood of Borrelia exposure. To test our hypothesis, a case-control study was carried out during 2019 in Serbia to determine the seroprevalence of anti-Borrelia antibodies in two case groups (individuals at risk and vaccinated against rabies virus) and a control group (individuals without risk of rabies). Individuals vaccinated against rabies following either “pre-exposure protocol” (PrEP, n = 58) or “post-exposure protocol” (PEP, n = 42) were considered as rabies risk groups and healthy blood donors (n = 30) as the control group. The results showed higher Borrelia seroprevalence in PrEP (17.2%, 10/58) and PEP (19.0%, 8/42) groups compared with the control group (6.67%, 2/30). Furthermore, odds ratio (OR) analysis showed that risk of rabies (in either the PrEP (OR = 2.91) or PEP (OR = 3.29) groups) is associated with increased odds of being seropositive to Borrelia. However, the difference in Borrelia seroprevalence between groups was not statistically significant (Chi-square (χ²) test p >, 0.05). The shared odds of LB and rabies exposure found in this study suggest that, in countries where both diseases occur, the common citizen can be at risk of both diseases when in a risky habitat. These findings are important to guide physicians in targeting high-risk groups, and diagnose LB, and to guide decision-makers in targeting control and prevention measures for both infections in risk areas.
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- 2021
4. Respiratory and cardiopulmonary nematode species of foxes and jackals in Serbia
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O. Bjelić Čabrilo, M. Miljević, Verica Simin, Dusan Lalosevic, Borislav Čabrilo, and Dragana Mijatović
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0301 basic medicine ,Medicine (General) ,Angiostrongylus vasorum ,Vulpes ,Agriculture (General) ,Zoology ,S1-972 ,03 medical and health sciences ,R5-920 ,red fox ,Abundance (ecology) ,biology.animal ,Helminths ,respiratory nematodes ,biology ,Host (biology) ,cardiopulmonary nematodes ,030108 mycology & parasitology ,biology.organism_classification ,jackal ,Nematode ,Jackal ,Canis aureus ,Animal Science and Zoology ,Parasitology ,Serbia ,Research Article - Abstract
Summary As part of routine monitoring of foxes (Vulpes vulpes) and jackals (Canis aureus) on the territory of Vojvodina province (northern Serbia), an analysis of respiratory and cardiopulmonary parasitic nematodes was conducted. Both host species harbored Eucoleus aerophilus, E. boehmi and Crenosoma vulpis, whereas Angiostrongylus vasorum was found only in foxes. A high prevalence of infection (72.6 %) was noted for E. aerophilus in foxes. The remaining parasite species occurred less frequently in both host species. In all species where it could be quantified, a high degree of parasite aggregation within host individuals was noted. Single species infections were most common, whereas two and three species infections occurred less frequently in both host species. The distribution of abundance of E. aerophilus was affected by host sex, with abundances higher in male foxes. Sampling site and year influenced abundance variation in E. boehmi.
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- 2018
5. Humans infested with Ixodes ricinus are exposed to a diverse array of tick-borne pathogens in Serbia
- Author
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Sara Moutailler, Adrian Alberto Díaz-Sánchez, Alejandro Cabezas-Cruz, Verica Simin, Dasiel Obregón, Dragana Mijatović, Pavle Banović, Clemence Galon, Pasteur Institute Novi Sad, University of Novi Sad, Department of Biology (University of Saskatchewan), University of Saskatchewan [Saskatoon] (U of S), Biologie moléculaire et immunologie parasitaires et fongiques (BIPAR), École nationale vétérinaire - Alfort (ENVA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Pristina-Kosovo, School of Environmental Sciences, University of Guelph, Federal University of Sao Paulo (Unifesp), Institut Pasteur de Serbie, Réseau International des Instituts Pasteur (RIIP), and École nationale vétérinaire d'Alfort (ENVA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé
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Male ,Nymph ,0301 basic medicine ,Veterinary medicine ,Ixodes ricinus ,Erythema migrans ,Borrelia valaisiana ,Rhipicephalus sanguineus ,030231 tropical medicine ,Borrelia miyamotoi ,Tick ,Real-Time Polymerase Chain Reaction ,medicine.disease_cause ,Borrelia afzelii ,Microbiology ,Tick-Borne pathogens ,03 medical and health sciences ,0302 clinical medicine ,Gram-Negative Bacteria ,parasitic diseases ,medicine ,Animals ,Humans ,Borrelia lusitaniae ,Rickettsia spp ,Aged ,Borrelia spp ,Ixodes ,biology ,High-Throughput Nucleotide Sequencing ,bacterial infections and mycoses ,biology.organism_classification ,3. Good health ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,030104 developmental biology ,Infectious Diseases ,Rickettsia helvetica ,Tick-Borne Diseases ,Larva ,Insect Science ,Female ,Parasitology ,Gram-Negative Bacterial Infections ,Serbia - Abstract
International audience; Tick-borne pathogens (TBPs) pose a major threat to human health in Europe and the whole northern hemisphere. Despite a high prevalence of TBPs in Ixodes ricinus ticks, knowledge on the incidence of tick-borne diseases in humans infested by this tick species is limited. This study was conducted in the year 2019 on patients who presented themselves to the Pasteur Institute Novi Sad with tick infestations. Ticks (n = 31) feeding on human (n = 30) and blood samples from the same individuals were collected by physicians and a microfluidic real-time high-throughput PCR system was used to test the genomic DNA of the samples for the presence of 27 bacterial and eight parasitic microorganisms in Serbia. Except for one Rhipicephalus sanguineus s.l. adult male tick, all ticks infesting humans were morphologically identified as I. ricinus. A high proportion of ticks (74 %, 23/31) were infected with at least one of the tested TB microorganisms, being Rickettsia helvetica (54 %, 17/31) the most common pathogen, but Borrelia afzelii (9 %, 3/31), Anaplasma phagocytophilum (6 %, 2/31), Borrelia miyamotoi (6 %, 2/31), and Francisella like-endosymbiont (6 %, 2/31), Borrelia valaisiana (3 %, 1/31), Borrelia lusitaniae (3 %, 1/31), Rickettsia felis (3 %, 1/31) and Rickettsia aeschlimannii (3 %, 1/31) were also identified. Despite the high infection rate of TBPs in ticks, only two human blood samples (6 %, 2/30) tested positive for the presence of TBPs, one patient (code H12, 67 years old female) was diagnosed with Borrelia spp. and the other patient was diagnosed (code H17, 71 years old female) with R. felis infection. The tick infesting patient H12 tested positive for B. afzelii, and R. helvetica and the tick infesting patient H17 tested positive for R. felis. Upon clinical examination, both patients were diagnosed with erythema migrans. No additional discomfort was reported by the patient and no additional pathology was observed by the physician. We concluded that humans bitten by I. ricinus in Serbia are exposed to a diverse array of TBPs with clinical impact in the Serbian cohort studied.
- Published
- 2021
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