1. Sequence analysis in Bos taurus reveals pervasiveness of X–Y arms races in mammalian lineages
- Author
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Ting-Jan Cho, Jennifer F. Hughes, Donna M. Muzny, James E. Womack, Kim C. Worley, Laura G. Brown, Lucinda Fulton, Catrina Fronick, Daniel W. Bellott, Bhanu P. Chowdhary, Elaine Owens, David C. Page, Shannon Dugan-Rocha, Tina A. Graves-Lindsay, Natalia Koutseva, Terje Raudsepp, Colin Kremitzki, Tatyana Pyntikova, Ziad Khan, William J. Murphy, Helen Skaletsky, Richard A. Gibbs, Wesley C. Warren, and Richard K. Wilson
- Subjects
0303 health sciences ,Sequence analysis ,Evolution of mammals ,Biology ,Y chromosome ,03 medical and health sciences ,0302 clinical medicine ,Evolutionary biology ,Convergent evolution ,Gene duplication ,Genetics ,Gene family ,Gene ,030217 neurology & neurosurgery ,Genetics (clinical) ,X chromosome ,030304 developmental biology - Abstract
Studies of Y Chromosome evolution have focused primarily on gene decay, a consequence of suppression of crossing-over with the X Chromosome. Here, we provide evidence that suppression of X–Y crossing-over unleashed a second dynamic: selfish X–Y arms races that reshaped the sex chromosomes in mammals as different as cattle, mice, and men. Using super-resolution sequencing, we explore the Y Chromosome of Bos taurus (bull) and find it to be dominated by massive, lineage-specific amplification of testis-expressed gene families, making it the most gene-dense Y Chromosome sequenced to date. As in mice, an X-linked homolog of a bull Y-amplified gene has become testis-specific and amplified. This evolutionary convergence implies that lineage-specific X–Y coevolution through gene amplification, and the selfish forces underlying this phenomenon, were dominatingly powerful among diverse mammalian lineages. Together with Y gene decay, X–Y arms races molded mammalian sex chromosomes and influenced the course of mammalian evolution.
- Published
- 2020