1. Sleep Apneas are Increased in Mice Lacking Monoamine Oxidase A
- Author
-
Isabelle Seif, Pierre Escourrou, Joëlle Adrien, Caroline Real, Daniela Popa, Jean-Marie Launay, and Jacques Callebert
- Subjects
medicine.medical_specialty ,Clorgyline ,Monoamine oxidase ,Rapid eye movement sleep ,Mice ,Sleep Apnea Syndromes ,Sleep and breathing ,Physiology (medical) ,Internal medicine ,medicine ,Animals ,Sleep Apnea and Monoamine Oxidase A ,Monoamine Oxidase ,Slow-wave sleep ,Mice, Knockout ,Neurons ,Sleep Stages ,biology ,business.industry ,Apnea ,Sleep apnea ,Brain ,medicine.disease ,Plethysmography ,Disease Models, Animal ,Endocrinology ,biology.protein ,Neurology (clinical) ,medicine.symptom ,Monoamine oxidase A ,business ,Receptors, Serotonin, 5-HT1 - Abstract
Study objectives: Alterations in the serotonin (5-HT) system have been suggested as a mechanism of sleep apnea in humans and rodents. The objective is to evaluate the contribution of 5-HT to this disorder. Design: We studied sleep and breathing (whole-body plethysmography) in mutant mice that lack monoamine oxidase A (MAOA) and have increased concentrations of monoamines, including 5-HT. Measurements and Results: Compared to wild-type mice, the mutants showed similar amounts of slow wave sleep (SWS) and rapid eye movement sleep (REMS), but exhibited a 3-fold increase in SWS and REMS apnea indices. Acute administration of the MAOA inhibitor clorgyline decreased REMS amounts and increased the apnea index in wild-type but not mutant mice. Parachlorophenylalanine, a 5-HT synthesis inhibitor, reduced whole brain concentrations of 5-HT in both strains, and induced a decrease in apnea index in mutant but not wild-type mice. Conclusion: Our results show that MAOA deficiency is associated with increased sleep apnea in mice and suggest that an acute or chronic excess of 5-HT contributes to this phenotype.
- Published
- 2007