1. PAKC: a novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin
- Author
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Xiangrui Kong, Robbert M. Spaapen, Arnoud H. de Ru, George M.C. Janssen, Sunesh Sethumadhavan, Tamara Verkerk, Frans H.J. Claas, Robert Tampé, Carolin Gerke, Peter A. van Veelen, Marlieke L.M. Jongsma, Arend Mulder, Kelly Hoefakker, Sophie Bliss, Antonius A. de Waard, Anne Halenius, AII - Inflammatory diseases, Graduate School, Landsteiner Laboratory, CCA - Cancer biology and immunology, and Experimental Immunology
- Subjects
0301 basic medicine ,media_common.quotation_subject ,Immunology ,Antigen presentation ,Histocompatibility Antigens Class I/immunology ,Autoimmunity ,Human leukocyte antigen ,Autoimmunity/immunology ,Major histocompatibility complex ,medicine.disease_cause ,Technical Comment ,03 medical and health sciences ,Presentation ,0302 clinical medicine ,Neoplasms ,Neoplasms/immunology ,medicine ,Immunology and Allergy ,CRISPR ,Humans ,Antigen Presentation/immunology ,Cas9 ,CRISPR/Cas9 ,media_common ,Signal Transduction/immunology ,biology ,Histocompatibility Antigens Class I ,HLA class I ,APM ,antigen presentation ,030104 developmental biology ,Cell culture ,biology.protein ,MHC ,030215 immunology ,Signal Transduction - Abstract
A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA-I research in the fields of oncology, infectiology, and autoimmunity.
- Published
- 2021