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10 results on '"Anna D. Barker"'

1. Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Author

Sandy Aronson, Leslie Cope, Michael L. Bittner, Daniel C. Koboldt, Alex E. Lash, W. K. Alfred Yung, Margaret Morgan, Devin Absher, Carl F. Schaefer, Roger E. McLendon, Michael D. Prados, Josh Gould, Ju Han, Stacey Gabriel, Scott R. VandenBerg, Ilana Perna, Troy Shelton, Junyuan Wu, Sacha Scott, Steve Scherer, Michael J. T. O’Kelly, Li Ding, Erin Hickey, Elizabeth J. Thomson, Bahram Parvin, Kim D. Delehaunty, Gi Choi Yoon, Mark D. Robinson, Oliver Bogler, Darrell D. Bigner, Michael R. Reich, Jianhua Zhang, Robert S. Fulton, Allan H. Friedman, Tammi L. Vickery, Amita Aggarwal, Subhashree Madhavan, Liuda Ziaugra, Yuan Qi, Vandita Joshi, Eric Van Name, Jane Wilkinson, W. Ruprecht Wiedemeyer, Xiaoqi Shi, Richard A. Gibbs, Lynda Chin, Jessica Chen, Stefano Monti, Erwin G. Van Meir, John Ngai, Amy Hawkins, Elizabeth Lenkiewicz, Brad Ozenberger, Shannon Dorton, Georgia Ren, John N. Weinstein, Gena M. Mastrogianakis, Asif T. Chinwalla, Scott L. Carter, Nicholas D. Socci, Rachel Abbott, Gavin Sherlock, Lucinda Fulton, Hyun Soo Kim, Fei Pan, Magali Cavatore, Gabriele Alexe, Francis S. Collins, Narayanan Sathiamoorthy, Lakshmi Jakkula, Brian H. Dunford-Shore, Jireh Santibanez, Tom Mikkelsen, Huy V. Nguyen, Levi A. Garraway, Christopher A. Miller, Jinghui Zhang, Ken Chen, Timothy Fennell, Robert Sfeir, James A. Robinson, Alexey Stukalov, Richard K. Wilson, Matthew Meyerson, Daniel J. Weisenberger, Mi Yi Joo, Yevgeniy Antipin, Anna Lapuk, Gerald V. Fontenay, Nicolas Stransky, Adam B. Olshen, Elizabeth Purdom, Josh Korn, Huyen Dinh, Sai Balu, Victoria Wang, James G. Herman, Christie Kovar, Kristian Cibulskis, Tisha Chung, Agnes Viale, Paul T. Spellman, Supriya Gupta, Melissa Parkin, Peter J. Park, Maddy Wiechert, John W. Wallis, Peter W. Laird, Nikolaus Schultz, James D. Brooks, David Nassau, Jun Li, John R. Osborne, Anna D. Barker, Peter Fielding, Boris Reva, Karen Vranizan, D. Neil Hayes, Aleksandar Milosavljevic, Lawrence A. Donehower, Won Kong Sek, Daniela S. Gerhard, Otis Hall, Rameen Beroukhim, Audrey Southwick, George M. Weinstock, Chris Markovic, Roel G.W. Verhaak, David Van Den Berg, Joe W. Gray, Yanru Ren, Ethan Cerami, Yiming Zhu, Amrita Ray, Yonghong Xiao, Kristin G. Ardlie, William L. Gerald, Michael S. Lawrence, Gerald R. Fowler, Mark S. Guyer, Isaac S. Kohane, Kornel E. Schuebel, Mitchel S. Berger, Jeffrey J. Olson, Gary W. Swift, Lora Lewis, Sheri Sanders, Norman L. Lehman, Eric S. Lander, Robert Penny, Liliana Villafania, John G. Conboy, Ari B. Kahn, Henry Marr, Heidi S. Feiler, Lynn Nazareth, David J. Dooling, Katherine A. Hoadley, Alicia Hawes, Marc Ladanyi, Aniko Sabo, Wendy Winckler, Vivian Peng, Barbara A. Weir, Daniel J. Brat, Scott Morris, Carolyn C. Compton, Todd R. Golub, Scott Abbott, Michael D. McLellan, Jiqiang Yao, Shalini N. Jhangiani, Michael D. Topal, Michael C. Wendl, Gad Getz, Jun Yao, Derek Y. Chiang, Larry Feng, Steffen Durinck, David A. Wheeler, Yuzhu Tang, Benjamin Gross, Barry S. Taylor, Kenneth Aldape, Craig Pohl, Rick Meyer, Peter J. Good, Ling Lin, Elaine R. Mardis, Robert C. Onofrio, Jane Peterson, Stephen B. Baylin, Li-Xuan Qin, Andrew Cree, Cameron Brennan, Charles M. Perou, William Courtney, Omar Alvi, Donna M. Muzny, Joseph G. Vockley, Jill P. Mesirov, Yan Shi, Alexei Protopopov, Jim Vaught, Craig H. Mermel, Scott Mahan, Laetitia Borsu, Heather Schmidt, Jennifer Baldwin, Tracie L. Miner, Toby Bloom, David E. Larson, Leander Van Neste, Nicholas J. Wang, Kenneth H. Buetow, Raju Kucherlapati, Anthony San Lucas, Martin L. Ferguson, Terence P. Speed, Venkatraman E. Seshan, Debbie Beasley, Carrie Sougnez, Carrie A. Haipek, Richard M. Myers, Chris Sander, Qing Wang Wei, Jon G. Seidman, Rob Nicol, Manuel L. Gonzalez-Garay, Shin Leong, Shannon T. Brady, and University of Groningen

Subjects
Male, Models, Molecular, DNA Repair, Gene Dosage, NEUROFIBROMATOSIS TYPE-1, MISMATCH REPAIR, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Genes, Tumor Suppressor, DNA Modification Methylases, Proneural Glioblastoma, Aged, 80 and over, Genetics, 0303 health sciences, Neurofibromin 1, Multidisciplinary, Brain Neoplasms, NF1 GENE, Genomics, Middle Aged, TUMORS, ALKYLATING-AGENTS, 3. Good health, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, DNA methylation, Female, DNA mismatch repair, Functional genomics, Signal Transduction, Adult, Adolescent, CELL-LINES, Oncogenomics, Biology, Article, 03 medical and health sciences, PIK3CA GENE, Humans, Epigenetics, Gene, Aged, Retrospective Studies, 030304 developmental biology, HIGH-FREQUENCY, Genome, Human, Tumor Suppressor Proteins, SOMATIC MUTATIONS, Genes, erbB-1, DNA Methylation, Protein Structure, Tertiary, MALIGNANT GLIOMAS, DNA Repair Enzymes, Mutation, Glioblastoma
Abstract

Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas ( TCGA) pilot project aims to assess the value of large- scale multi- dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community. Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas - the most common type of primary adult brain cancer - and nucleotide sequence aberrations in 91 of the 206 glioblastomas. This analysis provides new insights into the roles of ERBB2, NF1 and TP53, uncovers frequent mutations of the phosphatidylinositol- 3- OH kinase regulatory subunit gene PIK3R1, and provides a network view of the pathways altered in the development of glioblastoma. Furthermore, integration of mutation, DNA methylation and clinical treatment data reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated glioblastomas, an observation with potential clinical implications. Together, these findings establish the feasibility and power of TCGA, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.

Published
2008

2. IN VIVO STUDIES OF DIFFERENTIATION OF THYMUS-DERIVED LEUKEMIC CELLS

Author

Anna D. Barker and Samuel D. Waksal

Subjects
Pathology, medicine.medical_specialty, Lymphoma, Thymus Gland, Biology, General Biochemistry, Genetics and Molecular Biology, Rodent Diseases, Mice, Mice, Inbred AKR, Text mining, History and Philosophy of Science, In vivo, medicine, Animals, Transplantation, Homologous, Neoplasm, Leukemia, business.industry, General Neuroscience, Cell Differentiation, Organ Size, Thymectomy, medicine.disease, Transplantation, Lymphocyte Transfusion, Splenectomy, Lymph Nodes, business, Spleen
Published
1975

3. EFFECTS OF THYMOSIN ON CYTOTOXICITY AND VIRUS PRODUCTION IN AKR MICE

Author

Anthony J. Dennis, John Rice, Victor S. Moore, and Anna D. Barker

Subjects
Cytotoxicity, Immunologic, Aging, Spleen, Endogeny, Viral Plaque Assay, Biology, Virus Replication, General Biochemistry, Genetics and Molecular Biology, Virus, Mice, Mice, Inbred AKR, History and Philosophy of Science, medicine, Animals, Cytotoxic T cell, Lymphocytes, Cytotoxicity, General Neuroscience, Thymosin, Thymus Hormones, Retroviridae, medicine.anatomical_structure, Viral replication, Immunology, Splenectomy, Female, Lymph Nodes, Lymph, hormones, hormone substitutes, and hormone antagonists
Abstract

The cytotoxic potential and ability to produce endogenous ecotropic virus(es) of thymic-, splenic-, and lymph node-derived lymphocytes were significantly (and differentially) altered following thymosin treatment of young (nonleukemic) and aged (preleukemic) AKR mice. Thymosin administration markedly enhanced the cytotoxic potential of both splenic and lymph node lymphocytes from aged animals, but effected a moderate increase only in the spleens of young mice. Thymosin enhanced the production of endogenous virus(es) by thymocytes from aged mice, with the opposite effect noted in young animals. Splenectomy generally reduced the cytotoxic activity and virus titers of lymphocytes from both groups, and thymosin administration further reduced the cytotoxic response. These findings probably reflect overall effects on both regulatory lymphocyte subpopulations and different endogenous viruses in young and aged mice.

Published
1979

4. Thymus-derived lymphocyte differentiation and lymphocytic leukemias

Author

S D Waksal and Anna D. Barker

Subjects
Pathology, medicine.medical_specialty, Thymoma, Lymphocytic Leukemias, T cell, Immunology, Biology, medicine.disease, Organomegaly, Peripheral, medicine.anatomical_structure, medicine, Neoplasm, medicine.symptom, Lymph node, Homing (hematopoietic)
Abstract

The effects of transplanting thymic (LTC), splenic (LSC), and lymph node (LLNC) lymphocytes derived from overtly leukemic AKR mice into preleukemic syngeneic animals were studied. Each of these thymus-derived (T cell) populations produced a different and distinct pathology in recipient mice. Animals receiving LTC exhibited thymoma and enlargement of peripheral lymphoid tissues. Gross organomegaly was also noted in mice given LSC, but thymic atrophy was uniformly observed. The thymus appeared normal in mice receiving LLNC, but marked enlargement of peripheral lymphoid tissues again were observed. The differences noted in disease pathologies correlated with the “homing” patterns of the subpopulations investigated. These findings suggest that subpopulations of T cells exist in mice with a thymus-derived neoplastic disorder.

Published
1974

5. Amelioration of Friend Virus Leukemia by Sequential Administration of Viral and Nonviral Interferon Inducers

Author

Melvin S. Rheins, Anna D. Barker, and Henry E. Wilson

Subjects
Male, Sindbis virus, Polynucleotides, Spleen, General Biochemistry, Genetics and Molecular Biology, Virus, Mice, Cytopathogenic Effect, Viral, Polysaccharides, Interferon, Culture Techniques, Ethylamines, medicine, Animals, Fluorenes, Leukemia, Experimental, Interferon inducer, biology, Friend virus, Organ Size, Ketones, medicine.disease, biology.organism_classification, Virology, Friend murine leukemia virus, Leukemia, Poly I-C, medicine.anatomical_structure, Rickettsia, Liver, Immunology, Interferons, Sindbis Virus, Arboviruses, medicine.drug
Published
1971

6. The effect of rabbit anti-mouse brain-associated θ serum on the immunologic responsiveness of AKR mice

Author

Melvin S. Rheins, Ronald L.St. Pierre, and Anna D. Barker

Subjects
Isoantigens, medicine.medical_specialty, medicine.medical_treatment, Immunology, Hemolytic Plaque Technique, Spleen, Thymus Gland, Biology, Absorption, Mice, Mice, Inbred AKR, In vivo, Internal medicine, medicine, Animals, Neoplasm, Cytotoxic T cell, Lymphocytes, Antilymphocyte Serum, Immunosuppression Therapy, Antiserum, Mice, Inbred C3H, Leukemia, Experimental, Brain, Immunosuppression, Complement System Proteins, Cytotoxicity Tests, Immunologic, medicine.disease, In vitro, Endocrinology, medicine.anatomical_structure, Antibody Formation, Female, Rabbits, Precancerous Conditions
Abstract

Rabbit anti-C3H mouse brain-associated antiserum (BA-θ) was tested for its effect on the immunologic responsiveness of preleukemic and leukemic AKR mice to sheep erythrocytes. This BA-θ antiserum was cytotoxic in vitro for both C3H and for AKR thymocytes, and was immunosuppressive in vivo . Greater immunosuppression was effected by the antiserum in preleukemic AKR mice than in leukemic animals. Control rabbit serum also was cytotoxic in vitro and immunosuppressive in vivo , but this activity was removed by absorption with homologous erythrocytes and liver tissue, and with agarose. Conversely, absorption of the rabbit anti-BA-θ serum had no effect on either the in vitro cytotoxic activity, or on the in vivo immunosuppression.

Published
1973

7. Interferon induction in normal leukemic human lymphocyte cultures by tilorone hydrochloride

Author

Anna D. Barker, Melvin S. Rheins, Henry E. Wilson, and Anthony J. Dennis

Subjects
Interferon Inducers, Time Factors, Virus Cultivation, Leukemic Lymphocyte, Cell Survival, Lymphocyte, Pharmacology, Biology, General Biochemistry, Genetics and Molecular Biology, TILORONE HYDROCHLORIDE, Vesicular stomatitis Indiana virus, Interferon, medicine, Ethylamines, Humans, Inducer, Lymphocytes, Cells, Cultured, Human lymphocyte, Fluorenes, Ketones, In vitro, Leukemia, Lymphoid, medicine.anatomical_structure, Immunology, Interferons, Metabolic activity, medicine.drug
Abstract

SummaryLymphocytes recovered from normal donors and from patients with CLL were examined for interferon-producing capacity, following treatment with tilorone hydrochloride in vitro. The interferon response observed in normal lymphocyte cultures appeared to be correlated with the toxic effect of the inducer. The effect observed in the leukemic lymphocyte cultures was delayed, but of a similar magnitude. The data indicate that leukemic cells are either more resistant to the toxic effects of this agent, or their metabolic activity is less than observed in normal lymphocytes.

Published
1972

8. Immunologic responsiveness of young AKR mice to iodoacetate and to iodoacetate-treated tumor cells

Author

Henry E. Wilson, Melvin S. Rheins, G. W. Davis, and Anna D. Barker

Subjects
Erythrocytes, Thymoma, Immunology, Tumor cells, Hemolytic Plaque Technique, Iodoacetates, Thymus Gland, Biology, Mice, Mice, Inbred AKR, Immune system, medicine, Neoplasm, Animals, Lymphocytes, Leukemia, Experimental, Sheep, Single injection, medicine.disease, Radiation Effects, medicine.anatomical_structure, Antibody Formation, Red pulp, Female, Immunization, Spleen
Abstract

The effect of the sulfhydryl inhibitor iodoacetate and of iodoacetate-treated thymocytes from leukemic AKR mice (ITC) on the humoral immune response of preleukemic AKR mice (8 or 12 weeks old) to sheep erythrocytes (SRBC) was assessed. Six days after a single injection of iodoacetate or ITC (viable or nonviable), mice were administered SRBC, and their spleens and thymuses assayed for total number of plaque-forming cells (PFC) four days later. Histopathologic studies also were performed on samplings of mice from all test and control groups. Significant increases in total numbers of splenic PFC were noted in mice given either iodoacetate or viable ITC. Histopathologic examination of the spleens of AKR mice from these two groups revealed large numbers of mature lymphoid cells in the red pulp areas. The IgG response was absent in mice administered ITC (viable or nonviable).

Published
1973

9. Therapeutic and immunologic effects of iodoacetate in mature AKR mice

Author

Anna D. Barker and Melvin S. Rheins

Subjects
Pharmacology, Leukemia, Experimental, Cell Survival, Hemolytic Plaque Technique, Iodoacetates, Cell Biology, Biology, medicine.disease, Molecular biology, Serology, Cellular and Molecular Neuroscience, Mice, Mice, Inbred AKR, Immunoglobulin M, Immunoglobulin G, Immunology, medicine, Molecular Medicine, Neoplasm, Animals, Antibody-Producing Cells, Molecular Biology, Spleen
Abstract

A des souris AKR leucemiques on administre un total de 5 injections de sulfhydryle inhibiteur, iodoacetate, a 10 jours d'intervalle. Ce regime produit une augmentation de survivance moyenne de 15 jours par rapport au groupe temoin. 40% des souris traitees vivent dela de la periode d'experimentation. Chez certaines souris traitees, on constate l'augemtation statistiquement assez importante des nombres totaux de cellules spleniques formatrices de plaquettes a tous les stades d'experimentation.

Published
1973

10. International network of cancer genome projects

Author

Thomas J, Hudson, Warwick, Anderson, Axel, Artez, Anna D, Barker, Cindy, Bell, Rosa R, Bernabé, M K, Bhan, Fabien, Calvo, Iiro, Eerola, Daniela S, Gerhard, Alan, Guttmacher, Mark, Guyer, Fiona M, Hemsley, Jennifer L, Jennings, David, Kerr, Peter, Klatt, Patrik, Kolar, Jun, Kusada, David P, Lane, Frank, Laplace, Lu, Youyong, Gerd, Nettekoven, Brad, Ozenberger, Jane, Peterson, T S, Rao, Jacques, Remacle, Alan J, Schafer, Tatsuhiro, Shibata, Michael R, Stratton, Joseph G, Vockley, Koichi, Watanabe, Huanming, Yang, Matthew M F, Yuen, Bartha M, Knoppers, Martin, Bobrow, Anne, Cambon-Thomsen, Lynn G, Dressler, Stephanie O M, Dyke, Yann, Joly, Kazuto, Kato, Karen L, Kennedy, Pilar, Nicolás, Michael J, Parker, Emmanuelle, Rial-Sebbag, Carlos M, Romeo-Casabona, Kenna M, Shaw, Susan, Wallace, Georgia L, Wiesner, Nikolajs, Zeps, Peter, Lichter, Andrew V, Biankin, Christian, Chabannon, Lynda, Chin, Bruno, Clément, Enrique, de Alava, Françoise, Degos, Martin L, Ferguson, Peter, Geary, D Neil, Hayes, Amber L, Johns, Arek, Kasprzyk, Hidewaki, Nakagawa, Robert, Penny, Miguel A, Piris, Rajiv, Sarin, Aldo, Scarpa, Marc, van de Vijver, P Andrew, Futreal, Hiroyuki, Aburatani, Mónica, Bayés, David D L, Botwell, Peter J, Campbell, Xavier, Estivill, Sean M, Grimmond, Ivo, Gut, Martin, Hirst, Carlos, López-Otín, Partha, Majumder, Marco, Marra, John D, McPherson, Zemin, Ning, Xose S, Puente, Yijun, Ruan, Hendrik G, Stunnenberg, Harold, Swerdlow, Victor E, Velculescu, Richard K, Wilson, Hong H, Xue, Liu, Yang, Paul T, Spellman, Gary D, Bader, Paul C, Boutros, Paul, Flicek, Gad, Getz, Roderic, Guigó, Guangwu, Guo, David, Haussler, Simon, Heath, Tim J, Hubbard, Tao, Jiang, Steven M, Jones, Qibin, Li, Nuria, López-Bigas, Ruibang, Luo, Lakshmi, Muthuswamy, B F Francis, Ouellette, John V, Pearson, Victor, Quesada, Benjamin J, Raphael, Chris, Sander, Terence P, Speed, Lincoln D, Stein, Joshua M, Stuart, Jon W, Teague, Yasushi, Totoki, Tatsuhiko, Tsunoda, Alfonso, Valencia, David A, Wheeler, Honglong, Wu, Shancen, Zhao, Guangyu, Zhou, Mark, Lathrop, Gilles, Thomas, Teruhiko, Yoshida, Myles, Axton, Chris, Gunter, Linda J, Miller, Junjun, Zhang, Syed A, Haider, Jianxin, Wang, Christina K, Yung, Anthony, Cros, Anthony, Cross, Yong, Liang, Saravanamuttu, Gnaneshan, Jonathan, Guberman, Jack, Hsu, Don R C, Chalmers, Karl W, Hasel, Terry S H, Kaan, William W, Lowrance, Tohru, Masui, Laura Lyman, Rodriguez, Catherine, Vergely, David D L, Bowtell, Nicole, Cloonan, Anna, deFazio, James R, Eshleman, Dariush, Etemadmoghadam, Brooke B, Gardiner, Brooke A, Gardiner, James G, Kench, Robert L, Sutherland, Margaret A, Tempero, Nicola J, Waddell, Peter J, Wilson, Steve, Gallinger, Ming-Sound, Tsao, Patricia A, Shaw, Gloria M, Petersen, Debabrata, Mukhopadhyay, Ronald A, DePinho, Sarah, Thayer, Kamran, Shazand, Timothy, Beck, Michelle, Sam, Lee, Timms, Vanessa, Ballin, Youyong, Lu, Jiafu, Ji, Xiuqing, Zhang, Feng, Chen, Xueda, Hu, Qi, Yang, Geng, Tian, Lianhai, Zhang, Xiaofang, Xing, Xianghong, Li, Zhenggang, Zhu, Yingyan, Yu, Jun, Yu, Jörg, Tost, Paul, Brennan, Ivana, Holcatova, David, Zaridze, Alvis, Brazma, Lars, Egevard, Egor, Prokhortchouk, Rosamonde Elizabeth, Banks, Mathias, Uhlén, Juris, Viksna, Fredrik, Ponten, Konstantin, Skryabin, Ewan, Birney, Ake, Borg, Anne-Lise, Børresen-Dale, Carlos, Caldas, John A, Foekens, Sancha, Martin, Jorge S, Reis-Filho, Andrea L, Richardson, Christos, Sotiriou, Giles, Thoms, Laura, van't Veer, Daniel, Birnbaum, Hélène, Blanche, Pascal, Boucher, Sandrine, Boyault, Jocelyne D, Masson-Jacquemier, Iris, Pauporté, Xavier, Pivot, Anne, Vincent-Salomon, Eric, Tabone, Charles, Theillet, Isabelle, Treilleux, Paulette, Bioulac-Sage, Thomas, Decaens, Dominique, Franco, Marta, Gut, Didier, Samuel, Jessica, Zucman-Rossi, Roland, Eils, Benedikt, Brors, Jan O, Korbel, Andrey, Korshunov, Pablo, Landgraf, Hans, Lehrach, Stefan, Pfister, Bernhard, Radlwimmer, Guido, Reifenberger, Michael D, Taylor, Christof, von Kalle, Partha P, Majumder, Paolo, Pederzoli, Rita A, Lawlor, Massimo, Delledonne, Alberto, Bardelli, Thomas, Gress, David, Klimstra, Giuseppe, Zamboni, Yusuke, Nakamura, Satoru, Miyano, Akihiro, Fujimoto, Elias, Campo, Silvia, de Sanjosé, Emili, Montserrat, Marcos, González-Díaz, Pedro, Jares, Heinz, Himmelbauer, Heinz, Himmelbaue, Silvia, Bea, Samuel, Aparicio, Douglas F, Easton, Francis S, Collins, Carolyn C, Compton, Eric S, Lander, Wylie, Burke, Anthony R, Green, Stanley R, Hamilton, Olli P, Kallioniemi, Timothy J, Ley, Edison T, Liu, Brandon J, Wainwright, CCA -Cancer Center Amsterdam, Pathology, Other departments, Foie, métabolismes et cancer, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Universitat de Barcelona, The International Cancer Genome Consortium, and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Cancer therapy, Carcinogenesis, Genetics, Medical, International Cooperation, Systems biology, DNA Mutational Analysis, education, Genomics, Biology, Genome, Article, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Oncogènesi, Neoplasms, Databases, Genetic, medicine, Cancer genomics, Humans, Càncer, Molecular Biology, Cancer, 030304 developmental biology, Genetics, 0303 health sciences, Multidisciplinary, Genome, Human, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, DNA Methylation, medicine.disease, Intellectual Property, Human genetics, 3. Good health, Cancer Genome Project, 030220 oncology & carcinogenesis, Mutation, cancer genome projects, Human genome, Genes, Neoplasm
Abstract

International audience; The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumors from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of over 25,000 cancer genomes at the genomic, epigenomic, and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically-relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

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