1. Thyroid Function in Infertile Patients Undergoing Assisted Reproduction
- Author
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Marta Bianchini, Angela Fumarola, Giorgio Grani, Daniela Romanzi, Marianna Del Sordo, Alessia Aragona, Daniela Tranquilli, and Cesare Aragona
- Subjects
Infertility ,Adult ,endocrine system ,medicine.medical_specialty ,endocrine system diseases ,Pregnancy Rate ,Reproductive Techniques, Assisted ,media_common.quotation_subject ,Immunology ,Thyroid Gland ,Fertility ,Biology ,Iodide Peroxidase ,thyroid ,icsi ,embryos ,thyrotropin ,oocytes ,Young Adult ,Pregnancy ,medicine ,Immunology and Allergy ,Endocrine system ,Humans ,Embryo Implantation ,media_common ,Autoantibodies ,Retrospective Studies ,Gynecology ,Thyroid disease ,Thyroid ,Obstetrics and Gynecology ,medicine.disease ,Thyroid Diseases ,Embryo transfer ,medicine.anatomical_structure ,Reproductive Medicine ,Female ,Thyroid function ,Infertility, Female - Abstract
Problem Thyroid disease is one of the most common endocrine conditions affecting women during reproductive age. A link between thyroid and assisted reproduction outcome is debated. Method of study Serum TSH levels, number and scoring of oocytes and embryos, and number of clinical pregnancies were retrospectively recorded in 164 women undergoing assisted reproduction technologies (ART) at an University–based fertility center, to evaluate the outcome of the first steps of assisted reproduction (ovarian stimulation, oocyte pickup and fertilization, embryo transfer and implantation) in relation to thyroid function and autoimmunity. Results No significant relationship was found between TSH and all parameters, except clinical pregnancy rate (22.3% in TSH ≤ 2.5 group versus 8.9% in TSH > 2.5 mUI/L group; P = 0.045). No pregnancy occurred in women with anti-thyroperoxidase autoantibodies, while pregnancy occurred in 23.9% of cycles without autoimmunity (P = 0.02). Conclusion Further studies must be conducted in order to shed light on the link between infertility and thyroid dysfunction.
- Published
- 2013