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Your search keyword '"Wythes, Martin"' showing total 3 results
Start Over Author "Wythes, Martin" Topic biological sciences
3 results on '"Wythes, Martin"'

1. Synthesis of macrocyclic, potential protease inhibitors using a generic scaffold

Author

Dumez, Estelle, Snaith, John S., Jackson, Richard F. W., McElroy, Andrew B., Overington, John, Wythes, Martin J., Withka, Jane M., and McLellan, Thomas J.

Subjects
Chemistry, Organic -- Research, Cyclic compounds -- Physiological aspects, Proteases -- Physiological aspects, Chemical inhibitors -- Physiological aspects, Enzymes -- Physiological aspects, Peptides -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the macrocyclic peptides, potential proteinase inhibitors. The study of the generic structure of these peptides has been carried out using the structures of the known enzyme-inhibitor complexes.

Published
2002

2. A new approach to the synthesis of beta-hydroxy-alpha-amino acids using (arylthio)nitrooxiranes

Author

Jackson, Richard F.W., Palmer, Nicholas J., Wythes, Martin J., Clegg, William, and Elsegood, Mark R.G.

Subjects
Amino acids -- Synthesis, Chemical reactions -- Observations, Biological sciences, Chemistry
Abstract

The stereospecific reactions between enantiomerically and diastereoisomerically pure 2-(arylthio)-2-nitrooxiranes and ammonia is a stereocontrolled pathway to beta-hydroxy-alpha-amino acids with configurational inversion. Nucleophilic epoxidation of 1-(arylthio)-1-nitroalkenes by anhydrous metal alkyl peroxides lead to 2-(arylthio) in tetrahydrofuran.

Published
1995

3. Preparation of enantiomerically pure protected 4-oxo-alpha-amino acids and 3-aryl-alpha-amino acids from serine

Author

Jackson, Richard F.W., Wishart, Neil, Wood, Anthony a, James, Keith, and Wythes, Martin J.

Subjects
Organic compounds -- Synthesis, Chemical tests and reagents -- Research, Anions -- Research, Serine -- Usage, Alanine -- Usage, Zinc compounds -- Usage, Amino acids -- Synthesis, Biological sciences, Chemistry
Abstract

An organozinc reagent obtained by ultrasonication of protected beta-iodo alanine serves as a practical alanine beta-anion. In the presence of bis(triphenylphosphine)palladium chloride, it can be acylated with acid chlorides to give protected 4-oxo-alpha amino acids in up to 90% yield. In the presence of bis(tri-o-tolylphosphine)palladium dichloride, it couples with aryl iodides to form protected 3-aryl-alpha-amino acids in up to 67% yield. Both oxo and aryl products are enantiomerically pure and may be deprotected with ease, either at the carboxyl or amino ends, to provide synthons for peptide synthesis.

Published
1992

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