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Your search keyword '"Sarosi, Ildiko"' showing total 4 results
Start Over Author "Sarosi, Ildiko" Topic biological sciences
4 results on '"Sarosi, Ildiko"'

1. DREAM is a critical transcriptional repressor for pain modulation

Author

Cheng, Hai-Ying M., Pitcher, Graham M., Laviolette, Steven R., Whishaw, Ian Q., Tong, Kit I., Kockeritz, Lisa K., Wada, Teiji, Joza Nicholas A., Crackower, Michael, Goncalves, Jason, Sarosi, Ildiko, Woodgett, James R., Oliveira-dos-Santos, Antonio J., Ikura, Mitsuhiko, der Kooy, Derek van, Salter, Michael W., and Penninger, Josef

Subjects
Calcium-binding proteins -- Physiological aspects, Genetic transcription -- Analysis, Nociceptors -- Physiological aspects, Pain -- Physiological aspects, Biological sciences
Abstract

Results demonstrate that the calcium-sensing protein DREAM is involved in pain processing. Mutants lacking this protein respond poorly to acute thermal, mechanical, and visceral pain as well as to chronic neuropathic and inflammatory pain.

Published
2002

2. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

Author

Lomaga, Mark A., Yeh, Wen-Chen, Sarosi, Ildiko, Duncan, Gordon S., Furlonger, Caren, Ho, Alexandra, Morony, Sean, Capparelli, Casey, Van, Gwyneth, Kaufman, Stephen, Heiden, Annette van der, Itie, Annick, Wakeham, Andrew, Khoo, Wilson, Sasaki, Takehiko, Cao, Zhaodan, Penninger, Josef, Paige, Christopher J., Lacey, David L., Dunstan, Colin R., Boyle, William J., Goeddel, David V., and Mak, Tak W.

Subjects
Developmental biology -- Research, Osteopetrosis -- Genetic aspects, Interleukin-1 -- Genetic aspects, Tumor necrosis factor -- Genetic aspects, Biological sciences
Abstract

Bone resorption and remodeling is a very precisely controlled body process that requires osteoclasts to function as a part of the process. Mice that lack the TNF receptor-associated factor 6 (TRAF6) are osteopetrotic with defects in tooth eruption and bone remodeling, the result of impaired osteoclast activity. TRAF6 has been shown to be crucial in IL-1 and CD40 signaling and also in lipopolysaccharide (LPS) signaling, which would not be expected. It is essential for survival perinatally and postnatally, also unexpected.

Published
1999

3. Intravenous keratinocyte growth factor protects against experimental pulmonary injury

Author

Guo, Jane, Yi, Eunhee S., Havill, Andrew M., Sarosi, Ildiko, Whitcomb, Lane, Yin, Songmei, Middleton, Scot C., Piguet, Pierre, and Ulich, Thomas R.

Subjects
Growth factors -- Physiological aspects, Keratinocytes -- Research, Cell proliferation -- Research, Lungs -- Injuries, Biological sciences
Abstract

Intravenous keratinocyte growth factor (KGF) was shown to stimulate the proliferation of alveolar and bronchial cells in mice and rats. KGF was very effective in preventing experimental bleomycin-induced pulmonary dysfunction, weight loss and mortality in mice and rats. The effectiveness of intravenous KGF in preventing lung injury suggested that the mechanisms of the protective effect of KGF may involve more than pulmonary cell proliferation.

Published
1998

4. osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

Author

Bucay, Nathan, Sarosi, Ildiko, Dunstan, Colin R., Morony, Sean, Tarpley, John, Capparelli, Casey, Scully, Sheila, Hong Lin Tan, Weilong Xu, Lacey, David L., Boyle, William J., and Simonet, W. Scott

Subjects
Osteopetrosis -- Research, Calcification -- Research, Proteins -- Influence, Biological sciences
Abstract

Osteoprotegerin (OPG) plays a critical role in regulating postnatal bone mass. Experiments with OPG deficient mice also indicates a corelation between medial calcification of the aorta and renal arteries and the protein. This association between osteoporosis and arterial calcification opens possibilities for studying the impact of OPG regulation on these problems.

Published
1998

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