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Start Over Author "SATOH, SHOICHI" Topic biological sciences
1 results on '"SATOH, SHOICHI"'

1. Role of cytostolic Ca2+ and protein kinase C in developing myogenic contraction in isolated rat small arteries

Author

Karibe, Akihiko, Watanabe, Jun, Horiguchi, Satoru, Takeuchi, Masaharu, Suzuki, Shu, Funakoshi, Masayuki, Katoh, Hiroshi, Keitoku, Mitsumasa, Satoh, Shoichi, and Shirato, Kunio

Subjects
Muscle contraction -- Physiological aspects, Protein kinases -- Physiological aspects, Calcium in the body -- Physiological aspects, Vascular smooth muscle -- Physiological aspects, Enzyme inhibitors -- Physiological aspects, Biological sciences
Abstract

The interaction between protein kinase C activity and intracellular Ca2+ ([Ca2+]i) during myogenic contraction was analyzed in isolated rat skeletal muscles and mesenteric small arteries with fura 2. Myogenic contraction in isolated rat skeletal muscles and small arteries was attenuated by the inhibition of PKC with staurosporine without altering [Ca2+]i elevations in the skeletal muscles and small arteries. Furthermore, the effects of staurosporine indicated the cooperative role of PKC and [Ca2+]i elevations in the promotion of myogenic contraction.

Published
1997

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