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Your search keyword '"McKeown, Arlene E."' showing total 2 results
Start Over Author "McKeown, Arlene E." Topic biological sciences
2 results on '"McKeown, Arlene E."'

1. Asymmetric Diels-Alder reactions of chiral cyclopropylidene imide dienophiles: Preparation of gem-dimethyl- and spirocyclopropane norbornyl carboxylic acids

Author

Kuethe, Jeffrey T., Zhao, Daniel, Humphrey, Guy R., Journet, Michel, and McKeown, Arlene E.

Subjects
Carboxylic acids -- Chemical properties, Diels-Alder reaction -- Analysis, Cyclopropane compounds -- Chemical properties, Biological sciences, Chemistry
Abstract

A highly efficient strategy is developed for the rapid asymmetric synthesis of gem-dimethyl and spirocyclopropyl norbornyl carboxylic acids. The key transformation involved the unprecedented asymmetric Diels-Alder reaction of highly reaction beta,beta-cyclopropyl-alpha,beta-unsaturated N-acyloxazolidinoones with cyclopentadiene affording the adducts in high yield and de.

Published
2006

2. Stereoselective formation of carbon-carbon bonds via S(sub N)-displacement: Synthesis of substituted cycloalkyl[b]indoles

Author

Hillier, Michael C., Marcoux, Jean-Francois, Zhao, Dalian, Grabowski, Edward J.J., McKeown, Arlene E., and Tillyer, Richard D.

Subjects
Indole -- Chemical properties, Indole -- Structure, Carbon compounds -- Chemical properties, Carbon compounds -- Structure, Biological sciences, Chemistry
Abstract

A general asymmetric synthesis of substituted cycloalkyl[b]indoles is accomplished. The use of trimethylphosphine (PMe3) and bis(2,2,2-trichloroethyl) azodicarboxylate (TCEAD) is found to have an effect on the Mitsunobu dehydrative alkylation.

Published
2005

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