1. Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
- Author
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Ollmann, M., Young, L.M., De Como, C.J., Karim, F., Belvin, M., Robertson, S., Whittaker, K., Demsky, M., Fisher, W.W., Buchman, A., Duyk, G., Friedman, L., Prives, C., and Kopczynski, C.
- Subjects
Cytochemistry -- Research ,Carcinogenesis -- Genetic aspects ,Cell cycle -- Genetic aspects ,Cell death -- Genetic aspects ,Drosophila -- Usage ,Biological models -- Usage ,Genetic transcription -- Regulation ,Cellular signal transduction -- Research ,Tumor suppressor genes -- Physiological aspects ,DNA damage -- Research ,Biological sciences - Abstract
Drosophila p53 has been found to be a structural and functional homolog of the tumor suppressor p53. A Drosophila homolog of p53 has been identified. A function contributing to apoptosis has been found for p53. Drosophila is an good model system in which to find out about p53 apoptotic pathways brought on by DNA damage.
- Published
- 2000