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Your search keyword '"Liquid chromatography–mass spectrometry"' showing total 2 results
2 results on '"Liquid chromatography–mass spectrometry"'

1. Determination of mesoridazine by liquid chromatography–tandem mass spectrometry and its application to pharmacokinetic study in rats.

Author

Im, So Hee, Park, Myoung Joo, Seo, Hyewon, Choi, Sung Heum, Kim, Sang Kyum, and Ahn, Sung-Hoon

Subjects
*AZINES, *LIQUID chromatography-mass spectrometry, *PHARMACOKINETICS, *LABORATORY rats, *BIOLOGICAL assay, *PRECIPITATION (Chemistry)
Abstract

Highlights: [•] We develop an assay method for mesoridazine in rat plasma using LC–MS/MS. [•] We develop a simple, rapid, and sensitive method by simple protein precipitation. [•] This assay variability limits set forth in the FDA guidelines. [•] The present method can be applied to pharmacokinetic and/or toxicokinetic studies. [Copyright &y& Elsevier]

Published
2014
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2. Validated LC–MS/MS assay for quantitative determination of deoxypodophyllotoxin in rat plasma and its application in pharmacokinetic study.

Author

Yang, Yang, Chen, Yang, Zhong, Ze-Yu, Zhang, Ji, Li, Feng, Jia, Ling-Ling, Liu, Li, Zhu, Xiong, and Liu, Xiao-Dong

Subjects
*LIQUID chromatography-mass spectrometry, *BIOLOGICAL assay, *PODOPHYLLOTOXIN, *BLOOD plasma, *LABORATORY rats, *PHARMACOKINETICS
Abstract

Highlights: [•] A LC–MS/MS method was first developed and validated for the determination of deoxypodophyllotoxin in rat plasma. [•] Good peak shape and sensitivity with acceptable matrix effect could be obtained. [•] It is the first pharmacokinetic study of the intravenous administration of DPT in rats. [•] The pharmacokinetic parameters were obtained through two-compartment intravenous models analysis. [ABSTRACT FROM AUTHOR]

Published
2014
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