1. Synthesis, characterization, biological activity and equilibrium studies of metal(II) ion complexes with tridentate hydrazone ligand derived from hydralazine
- Author
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El-Sherif, Ahmed A., Shoukry, Mohamed M., and Abd-Elgawad, Mohamed M.A.
- Subjects
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LIGANDS (Chemistry) , *METAL ions , *HYDRAZONES , *HYDRALAZINE , *PHTHALAZINE , *CHEMICAL synthesis , *METAL complexes , *INFRARED spectroscopy , *NUCLEAR magnetic resonance spectroscopy - Abstract
Abstract: In the present study, a new hydrazone ligand (2-((2-phthalazin-1-yl)hydrazono)methyl)phenol) prepared by condensation of hydralazine (1-Hydralazinophthalazine) with salicylaldehyde (SAH). The synthesized SAH-hydrazone and its metal complexes have been characterized by elemental analyses, IR, 1H NMR, solid reflectance, magnetic moment, molar conductance, mass spectra, UV–vis and thermal analysis (TGA). The analytical data of the complexes show the formation of 1:1 [M:L] ratio, where M represents Ni(II), Co(II) and Cu(II) ions, while L represents the deprotonated hydrazone ligand. IR spectra show that SAH is coordinated to the metal ions in a tridentate manner through phthalazine-N, azomethine-N and phenolic-oxygen groups. The ligand and their metal chelates have been screened for their antimicrobial activities using the disc diffusion method against the selected bacteria and fungi. Proton-ligand association constants of (SAH) and the stepwise stability constants of its metal complexes are determined potentiometrically in 0.1M NaNO3 at different temperatures and the corresponding thermodynamic parameters were derived and discussed. The order of −ΔG° and −ΔH° were found to obey Mn2+
- Published
- 2012
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