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We study the tandem duplication distance between binary sequences and their roots. In other words, the quantity of interest is the number of tandem duplication operations of the form x = {a} {b} {c} \to {y} = {a} {b} {b} {c} , where x and y are sequences and a , b , and c are their substrings, needed to generate a binary sequence of length $n$ starting from a square-free sequence from the set {0, 1, 01, 10, 010, 101}. This problem is a restricted case of finding the duplication/deduplication distance between two sequences, defined as the minimum number of duplication and deduplication operations required to transform one sequence to the other. We consider both exact and approximate tandem duplications. For exact duplication, denoting the maximum distance to the root of a sequence of length $n$ by $f(n)$ , we prove that $f(n)=\Theta (n)$ . For the case of approximate duplication, where a $\beta $ -fraction of symbols may be duplicated incorrectly, we show that the maximum distance has a sharp transition from linear in $n$ to logarithmic at $\beta =1/2$ . We also study the duplication distance to the root for the set of sequences arising from a given root and for special classes of sequences, namely, the De Bruijn sequences, the Thue–Morse sequence, and the Fibonacci words. The problem is motivated by genomic tandem duplication mutations and the smallest number of tandem duplication events required to generate a given biological sequence. [ABSTRACT FROM AUTHOR]

The majority of the human genome consists of repeated sequences. An important type of repeated sequences common in the human genome are tandem repeats, where identical copies appear next to each other. For example, in the sequence AGTC\underline TGTGC , $TGTG$ is a tandem repeat, that may be generated from $AGTCTGC$ by a tandem duplication of length 2. In this paper, we investigate the possibility of generating a large number of sequences from a seed, i.e. a small initial string, by tandem duplications of bounded length. We study the capacity of such a system, a notion that quantifies the system’s generating power. Our results include exact capacity values for certain tandem duplication string systems. In addition, motivated by the role of DNA sequences in expressing proteins via RNA and the genetic code, we define the notion of the expressiveness of a tandem duplication system as the capability of expressing arbitrary substrings. We then completely characterize the expressiveness of tandem duplication systems for general alphabet sizes and duplication lengths. In particular, based on a celebrated result by Axel Thue from 1906, presenting a construction for ternary squarefree sequences, we show that for alphabets of size 4 or larger, bounded tandem duplication systems, regardless of the seed and the bound on duplication length, are not fully expressive, i.e. they cannot generate all strings even as substrings of other strings. Note that the alphabet of size 4 is of particular interest as it pertains to the genomic alphabet. Building on this result, we also show that these systems do not have full capacity. In general, our results illustrate that duplication lengths play a more significant role than the seed in generating a large number of sequences for these systems. [ABSTRACT FROM PUBLISHER]

It is known that the majority of the human genome consists of duplicated sequences. Furthermore, it is believed that a significant part of the rest of the genome also originated from duplicated sequences and has mutated to its current form. In this paper, we investigate the possibility of constructing an exponentially large number of sequences from a short initial sequence using simple duplication rules, including those resembling genomic-duplication processes. In other words, our goal is to find the capacity, or the expressive power, of these string-duplication systems. Our results include exact capacities, and bounds on the capacities, of four fundamental string-duplication systems. The study of these fundamental biologically inspired systems is an important step toward modeling and analyzing more complex biological processes. [ABSTRACT FROM AUTHOR]

We propose a new family of distance measures on rankings, derived through an axiomatic approach, that consider the nonuniform relevance of the top and bottom of ordered lists and similarities between candidates. The proposed distance functions include specialized weighted versions of the Kendall \(\tau \) distance and the Cayley distance, and are suitable for comparing rankings in a number of applications, including information retrieval and rank aggregation. In addition to proposing the distance measures and providing the theoretical underpinnings for their applications, we also analyze algorithmic and computational aspects of weighted distance-based rank aggregation. We present an aggregation method based on approximating weighted distance measures by a generalized version of Spearman’s footrule distance as well as a Markov chain method inspired by PageRank, where transition probabilities of the Markov chain reflect the chosen weighted distances. [ABSTRACT FROM AUTHOR]

The problem of finding a minimum decomposition of a permutation in terms of transpositions with predetermined non-uniform and non-negative costs is addressed. Alternatively, computing the transposition distance between two permutations, where transpositions are endowed with arbitrary non-negative costs, is studied. For such cost functions, polynomial-time, constant-approximation decomposition algorithms are described. For metric-path costs, exact polynomial-time decomposition algorithms are presented. The algorithms in this paper represent a combination of Viterbi-type algorithms and graph-search techniques for minimizing the cost of individual transpositions, and dynamic programing algorithms for finding minimum cost decompositions of cycles. The presented algorithms have a myriad of applications in information theory, bioinformatics, and algebra. [ABSTRACT FROM PUBLISHER]