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The development and scientific priorities of European urology of the second half of the XIX and early XX centuries are analyzed. The main dates of life and scientific and practical activity of Prof. Leopold Kasper are presented. The scientific views and thoughts of the scientist are noted. He specialized in urology under the leadership of G. Thompson, P. Freyer, F. Guyon, I. Albarran and L. Dittel after graduating from the University of Berlin in 1883. L. Kasper was the founder of a large German urological school. In addition, he is the author of many works, among which research on cystoscopy, endoscopic operations, functional diagnosis of kidneys diseases, treatment of renal tuberculosis and kidney stone disease, prostate diseases, transurethral galvanocaustics of bladder tumors, etc. are particularly distinguished. He constructed a special catheterization cystoscope (1895) through which for the first time it became possible to study the functional ability of each kidney individually, which greatly facilitated the recognition and treatment of surgical diseases of the kidneys and upper urinary tract. He improved and put into practice a functional renal test with floridzine and cryoscopic urine examination obtained from each kidney separately by catheterization of the ureters. It is noted that L. Kasper was one of the founders of the Society of German urologists, whose founding meeting was held in 1907 in Vienna. In the same year, L. Kasper, together with other prominent surgeons and urologists, founded the journal «Zeitschrift für Urologie», of which he was editor for decades. L. Kasper was an honorary member of nineteen scientific societies, including the Society of Moscow urologists, of which he was elected an honorary member in 1924.

The main milestones of the life and work of L.O. Darkshevich. It is noted that the work of a professor on the study of the pathology of muscles and peripheral nerves is of great interest. As early as 1903, in a German manual on pathological anatomy of the nervous system, Liverius Osipovich wrote a chapter on the pathological anatomy of muscles. We emphasize that later they wrote several articles on cerebral and arthropathic amiotrophies. Studying the question of the so-called retrograde degeneration of nerves, he pointed to the development of degenerative changes not only in the peripheral, but also in the central segment of the nerve, which is of great interest for clarifying the spread of the process. The article notes that Liveriy Osipovich Darkshevich considered the creation of a manual on nervous diseases as the greatest debt of his life, which was the testament of his late teacher — Professor A.Ya. Kozhevnikov, who had not managed to do this. Well aware of the conditioned reflex principles of the central nervous system, Liverii Osipovich attached special importance to the cerebral cortex as a body of mental activity. He pointed out that normal mental activity is formed under the influence of incessantly arriving stimuli of the external world, which, having reached the cerebral cortex and entering our consciousness, give rise to representations, the appearance of which in turn gives rise to the manifestation of active cortical activity-the emergence of volitional impulses. Liverii Osipovich was an ardent supporter of active disease therapy and was often an innovator in this field.

This article presents the important scientific achievements of S.P. Fedorov as a urologist. S.P. Fedorov is the author of over 120 scientific papers. It was noted that in 1892 he was the first in Russia to prepare and use cholera antitoxin for the treatment of patients, then tetanus toxin and antitoxin, found that antitoxin protects against tetanus if it is administered simultaneously with the toxin. Abroad S.P. Fedorov studied the system of aseptic mode of operation from K. Schimmelbush, and L. Casper studied the method of cystoscopy and catheterization of the ureters and other endoscopic methods that appeared at that time. It was shown that S.P. Fedorov developed new surgeries — in situ pyelotomy, subcapsular nephrectomy, and new surgical instruments were proposed. He is rightly called the father of Russian urology. The circumstance is analyzed that the main direction of S.P. Fedorov's scientific activity was the problems of surgery of the urinary and biliary tracts. He summarized the extensive experience of the surgeon in the Atlas of Cystoscopy and Rectoscopy (1911), the Surgery of the Kidneys and Ureters (1923-1925), and others. Galpernom edition of the surgical journal «New Surgical Archive», essentially the first Soviet surgical journal, created in the difficult years of the Civil War and post-war devastation. He was the editor of the 1st edition of the BME, together with S.S. Girgolavom and A.V. Martynov was the editor of the multivolume Guide to Practical Surgery. S.P. Fedorov created a major domestic surgical school, from which dozens of specialists, heads of surgical departments of medical universities in various cities of the USSR graduated. The name of S.P. Fedorov was given to the department of hospital surgery of the Military Medical Academy. S.M. Kirov. It is noted that he was the first of the Soviet surgeons to be awarded the Order of Lenin (1933).

The article notes that James Israel and Max Nitze have successfully developed European medicine for more than 30 years of their scientific and practical activities, enriching it with both experimental and large clinical experience. Their scientific achievements greatly contributed to the development of modern clinical urology throughout the world. Based on an analysis of the results of more than 1000 nephrectomy operations for tuberculosis, Izrael made a conclusion about the effectiveness of surgical treatment of this disease. In addition to kidney surgery, J. Israel developed questions of rhinoplasty. He participated in the International Congress of Physicians in Moscow (1897), where he reported on 191 kidney operations. He was an honorary member of the German Society of Surgeons, the Berlin Society of Urology, President of the International Congress of Urology (Paris, 1908). The main merit of M. Nitze is the invention of a cystoscope, in which for the first time an electric light source for illuminating the bladder was located at the end of a tool inserted into the bladder. The invention of the cystoscope contributed to the development of urology as an independent clinical discipline and marked the beginning of endoscopic studies of various organs and body cavities. It is analyzed the fact that the history of medicine gives rich material not only to understanding evolution, but also to the possibility to foresee its further development. The current state of clinical urology is determined by the progress of basic research in biology, physics, biochemistry, bacteriology, immunology, pharmacology. At the same time, it was noted that the personality of the scientist-physician, his observation, the non-standard view, the ability to see the opening perspectives, to bring up worthy students, to create a scientific and clinical school of urologists, is of utmost importance, at the same time, to the full compliance of the great German urologists J Israel and M. Nitze.Disclosure: The study did not have sponsorship. The author declares no conflict of interest.