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Biofertilizers can increase the growth and yield of potatoes. However, each cultivar's response to biofertilizers' application varies greatly. This study aimed to examine the response of cultivars to the application of biofertilizers. The study was conducted at the plastic house of Cikole Village, Lembang District, West Bandung Regency, West Java, Indonesia from September 2020 to January 2021. The study used a randomized block design with two treatment factors and three replications. The first treatment factor was processed potato cultivars, namely Papita Agrihorti, Spudy Agrihorti, AR 08 Agrihorti, and Medians. The second factor was five types of biofertilizers: Trichoderma, Gliocompost, and Mycorrhizae, a single treatment of each biofertilizer, and control. Data were analyzed by ANOVA and if there was a significant difference, continued with Duncan's and correlation test. The results showed that the cultivar treatment had a significant effect, while the biofertilizer treatment had no significant effect on plant height and tuber weight per plant. The best cultivar treatment for plant height and tuber weight per plant was Papita Agrihorti. The types of biofertilizer on four potato cultivars gave various effects on the yield components of the number of small, medium, and large tubers, the total number of tubers per plant, and tuber weight per plant. [ABSTRACT FROM AUTHOR]