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Your search keyword '"Fluoro-carbohydrates"' showing total 1 results
Start Over Descriptor "Fluoro-carbohydrates" Topic bioconjugates
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1. Pyrazole-type cannabinoid ligands conjugated with fluoro-deoxy-carbohydrates as potential PET-imaging agents: Synthesis and CB1/CB2 receptor affinity evaluation.

Author

Frau, Simona, Dall’Angelo, Sergio, Baillie, Gemma L., Ross, Ruth A., Pira, Marilena, Tseng, Chih-Chung, Lazzari, Paolo, and Zanda, Matteo

Subjects
*PYRAZOLES, *CANNABINOIDS, *LIGANDS (Chemistry), *CARBOHYDRATES, *POSITRON emission tomography, *CHEMICAL synthesis, *BIOCONJUGATES
Abstract

Highlights: [•] A novel class of cannabinoid ligands was synthesised in good overall yields. [•] Key reaction was a bioconjugation of NH2O-pyrazoles and fluorodeoxy-carbohydrates. [•] D-5-fluoro-5-deoxy-ribose (FDR) proved to be superior to FDG conjugation. [•] Title compounds showed modest affinity for the CB1 and selectivity vs. the CB2. [Copyright &y& Elsevier]

Published
2013
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