Author: "Falcone, Danielle" / Topic: bioconjugates - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "Falcone, Danielle" Topic bioconjugates

Author: Falcone, Danielle, Li, Jane, Kale, Amit, and Jones, Graham B.
Subjects: *ENEDIYNES, *NANOPARTICLES, *MONOCLONAL antibodies, *BIOCONJUGATES
Abstract: Abstract: Efficient syntheses of a series of functionalized aryl enediynes have been developed. The building blocks were used to effect conjugation to carrier PEG templates which allowed subsequent coupling to a cardiac targeted monoclonal antibody. Immunocompetence of the enediyne-Mab conjugates was demonstrated by ELISA, and both parent enediynes and bioconjugates underwent successful photo-Bergman cyclization. Finally, surface modified (Au) nanoparticle conjugates were prepared and size confirmed by TEM analysis. Application as long-circulating photoactivated prodrugs is anticipated. [Copyright &y& Elsevier]
Published: 2008
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Author: LaBeaume, Paul, Wager, Krista, Falcone, Danielle, Li, Jane, Torchilin, Vladimir, Castro, Curtis, Holewa, Coleen, Kallmerten, Amy E., and Jones, Graham B.
Subjects: *ENEDIYNES, *BIOCONJUGATES, *CHEMICAL templates, *SOLUBLE salts, *IMMUNOGLOBULINS, *CHEMICAL reagents, *PHOTOCHEMOTHERAPY, *ORGANIC synthesis
Abstract: Abstract: Methodology is outlined for the chemical synthesis of versatile photo-Bergman enediyne building blocks and their conjugates. Routes to both mono and bis conjugated enediyne templates are detailed together with representative examples of their bioconjugates, nanoconjugates, PEG derivatives and water soluble salts. The immunocompetence of antibody conjugates is retained, and application in the form of reagents for photodynamic therapy (PDT) advanced. [Copyright &y& Elsevier]
Published: 2009
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