Search

Your search keyword '"Rosa, Fabiana Paim"' showing total 5 results
Start Over Author "Rosa, Fabiana Paim" Topic biocompatible materials
5 results on '"Rosa, Fabiana Paim"'

1. Biological evaluation of critical bone defect regeneration using hydroxyapatite/ alginate composite granules.

Author

Ribeiro IÍDA, Almeida RDS, Silva AMGBD, Barbosa Júnior AA, Rossi AM, Miguel FB, and Rosa FP

Subjects
Animals, Male, Random Allocation, Osteogenesis drug effects, Osteogenesis physiology, Hexuronic Acids pharmacology, Glucuronic Acid pharmacology, Skull surgery, Skull drug effects, Time Factors, Rats, Reproducibility of Results, Rats, Wistar, Bone Regeneration drug effects, Bone Regeneration physiology, Alginates pharmacology, Durapatite pharmacology, Durapatite therapeutic use, Biocompatible Materials therapeutic use, Materials Testing, Bone Substitutes therapeutic use
Abstract

Purpose: to evaluate biocompatibility and osteogenic potential of hydroxyapatite/alginate composite after its implantation on rat calvarian critical bone defect., Methods: thirty adults male Wistar rats were randomly distributed into two groups: GHA - critical bone defect filled with hydroxyapatite/alginate composite granules (HA/Alg) and CG - critical bone defect without biomaterial; evaluated at biological points of 15, 45 and 120 days., Results: the histomorphometrically analyses for GHA showed osteoid matrix deposition (OM) among the granules and towards the center of the defect in centripetal direction throughout the study, with evident new bone formation at 120 days, resulting in filling 4/5 of the initial bone defect. For CG, this finding was restricted to the edges of the bone margins and formation of connective tissue on the residual area was found in all biological points. Inflammatory response on GHA was chronic granulomatous type, discrete and regressive for all biological points. Throughout the study, the CG presented mononuclear inflammatory infiltrate diffuse and regressive. Histomorphometry analyses showed that OM percentage was evident for GHA group when compared to CG group in all analyzed periods (p > 0.05)., Conclusions: the biomaterial evaluated at this study showed to be biocompatible, bioactive, osteoconductive and biodegradable synchronously with bone formation.

Published
2024
Full Text
View/download PDF

2. Influence of the geometry of nanostructured hydroxyapatite and alginate composites in the initial phase of bone repair1.

Author

Santos GGD, Vasconcelos LQ, Poy SCDS, Almeida RDS, Barbosa Júnior AA, Santos SRA, Rossi AM, Miguel FB, and Rosa FP

Subjects
Alginates administration & dosage, Animals, Biocompatible Materials administration & dosage, Bone Regeneration physiology, Durapatite administration & dosage, Male, Nanostructures administration & dosage, Rats, Rats, Wistar, Spectrophotometry, Infrared, Alginates chemistry, Biocompatible Materials chemistry, Bone Regeneration drug effects, Durapatite chemistry, Nanostructures chemistry
Abstract

Purpose: To analyze, histomorphologically, the influence of the geometry of nanostructured hydroxyapatite and alginate (HAn/Alg) composites in the initial phase of the bone repair., Methods: Fifteen rats were distributed to three groups: MiHA - bone defect filled with HAn/Alg microspheres; GrHA - bone defect filled with HAn/Alg granules; and DV - empty bone defect; evaluated after 15 days postoperatively. The experimental surgical model was the critical bone defect, ≅8.5 mm, in rat calvaria. After euthanasia the specimens were embedded in paraffin and stained with hematoxylin and eosin, picrosirius and Masson-Goldner's trichrome., Results: The histomorphologic analysis showed, in the MiHA, deposition of osteoid matrix within some microspheres and circumjacent to the others, near the bone edges. In GrHA, the deposition of this matrix was scarce inside and adjacent to the granules. In these two groups, chronic granulomatous inflammation was noted, more evident in GrHA. In the DV, it was observed bone neoformation restricted to the bone edges and formation of connective tissue with reduced thickness in relation to the bone edges, throughout the defect., Conclusion: The geometry of the biomaterials was determinant in the tissue response, since the microspheres showed more favorable to the bone regeneration in relation to the granules.

Published
2019
Full Text
View/download PDF

3. Influence of the geometry of nanostructured hydroxyapatite and alginate composites in the initial phase of bone repair 1

Author

dos Santos, George Gonçalves, Vasconcelos, Luisa Queiroz, Poy, Suelen Cristina da Silva, Almeida, Renata dos Santos, Barbosa, Aryon de Almeida, Santos, Silvia Rachel de Albuquerque, Rossi, Alexandre Malta, Miguel, Fúlvio Borges, and Rosa, Fabiana Paim

Subjects
Male, Bone Regeneration, Spectrophotometry, Infrared, Alginates, Polymers, Biocompatible Materials, Microspheres, Rats, Nanostructures, Durapatite, Experimental Surgery, Animals, Rats, Wistar, ORIGINAL ARTICLE
Abstract

Purpose To analyze, histomorphologically, the influence of the geometry of nanostructured hydroxyapatite and alginate (HAn/Alg) composites in the initial phase of the bone repair. Methods Fifteen rats were distributed to three groups: MiHA - bone defect filled with HAn/Alg microspheres; GrHA - bone defect filled with HAn/Alg granules; and DV - empty bone defect; evaluated after 15 days postoperatively. The experimental surgical model was the critical bone defect, ≅8.5 mm, in rat calvaria. After euthanasia the specimens were embedded in paraffin and stained with hematoxylin and eosin, picrosirius and Masson-Goldner’s trichrome. Results The histomorphologic analysis showed, in the MiHA, deposition of osteoid matrix within some microspheres and circumjacent to the others, near the bone edges. In GrHA, the deposition of this matrix was scarce inside and adjacent to the granules. In these two groups, chronic granulomatous inflammation was noted, more evident in GrHA. In the DV, it was observed bone neoformation restricted to the bone edges and formation of connective tissue with reduced thickness in relation to the bone edges, throughout the defect. Conclusion The geometry of the biomaterials was determinant in the tissue response, since the microspheres showed more favorable to the bone regeneration in relation to the granules.

Published
2019

4. Avaliação de hidroxiapatita bovina no reparo de defeitos ósseos críticos em calvária de rato

Author

Campos, Lilian Souza and Rosa, Fabiana Paim

Subjects
Bioengenharia, Regeneração óssea, Bone Regeneration, Xenograft, Biomateriais, Biocompatible Materials, Bioengineering, Xenoenxerto
Abstract

p. 177-183 Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-06-03T19:24:59Z No. of bitstreams: 1 TTTTTTTTTTT48.pdf: 325948 bytes, checksum: cd728dcbfa662917c85a312fb7443425 (MD5) Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-06-05T19:44:50Z (GMT) No. of bitstreams: 1 TTTTTTTTTTT48.pdf: 325948 bytes, checksum: cd728dcbfa662917c85a312fb7443425 (MD5) Made available in DSpace on 2013-06-05T19:44:51Z (GMT). No. of bitstreams: 1 TTTTTTTTTTT48.pdf: 325948 bytes, checksum: cd728dcbfa662917c85a312fb7443425 (MD5) Previous issue date: 2012 Introdução: Dentre os biomateriais para regeneração óssea, os de origem xenogênica têm se mostrado como alternativa ao autoenxerto devido às suas propriedades biológicas e físico-químicas, além de sua grande disponibilidade e de minimizar a morbidade ao indivíduo. Vários trabalhos consideram o BioOss®, uma hidroxiapatita bovina, como padrão ouro entre os biomateriais de substituição óssea, independentemente do tamanho de suas partículas, apesar de esse fator ser considerado importante nas reações tissulares envolvidas na neoformação óssea. Objetivo: Avaliar histologicamente o comportamento biológico de uma Hidroxiapatita Bovina, na forma de grânulos, entre 0,4 a 0,6 mm, implantados em defeitos ósseos críticos em calvária de rato. Metodologia: Foram utilizados 20 ratos distribuídos em 2 grupos experimentais: Grupo GC (controle com coágulo) e Grupo GBS (implantados com hidroxiapatita bovina) nos quais foi efetuado um defeito crítico de 8,5 mm de diâmetro na calvária. A eutanásia foi realizada em dois pontos biológicos, aos 15 e 45 dias pós-operatórios e os espécimes foram processados para inclusão em parafina. Os cortes histológicos foram corados pela técnica de hematoxilina e eosina (HE), e picrossírius-vermelho (PIFG), e foram analisados histologicamente em microscópio de luz comum. Resultados: No grupo controle, observou-se, neoformação óssea reacional restrita às bordas e presença de tecido fibroso na área do defeito. No grupo implantado com BioOss®, observouse mínima reação inflamatória, abundante angiogênese e alguma osteogênese, além das bordas, ao longo do defeito, especialmente em continuidade à dura-máter. Conclusão: Concluiu-se que o BioOss® foi biocompatível e promoveu osteogênese por osteocondução, mantendo-se parcialmente integrado ao osso neoformado. Salvador

Published
2012

5. Revista de Ciências Médicas e Biológicas

Author

Campos, Lilian Souza and Rosa, Fabiana Paim

Subjects
Bioengenharia, Bone Regeneration, Xenograft, Regeneração óssea, Biocompatible Materials, Bioengineering, Xenoenxerto, Biomateriais
Abstract

p. 177-183 Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-06-03T19:24:59Z No. of bitstreams: 1 TTTTTTTTTTT48.pdf: 325948 bytes, checksum: cd728dcbfa662917c85a312fb7443425 (MD5) Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-06-05T19:44:50Z (GMT) No. of bitstreams: 1 TTTTTTTTTTT48.pdf: 325948 bytes, checksum: cd728dcbfa662917c85a312fb7443425 (MD5) Made available in DSpace on 2013-06-05T19:44:51Z (GMT). No. of bitstreams: 1 TTTTTTTTTTT48.pdf: 325948 bytes, checksum: cd728dcbfa662917c85a312fb7443425 (MD5) Previous issue date: 2012 Introdução: Dentre os biomateriais para regeneração óssea, os de origem xenogênica têm se mostrado como alternativa ao autoenxerto devido às suas propriedades biológicas e físico-químicas, além de sua grande disponibilidade e de minimizar a morbidade ao indivíduo. Vários trabalhos consideram o BioOss®, uma hidroxiapatita bovina, como padrão ouro entre os biomateriais de substituição óssea, independentemente do tamanho de suas partículas, apesar de esse fator ser considerado importante nas reações tissulares envolvidas na neoformação óssea. Objetivo: Avaliar histologicamente o comportamento biológico de uma Hidroxiapatita Bovina, na forma de grânulos, entre 0,4 a 0,6 mm, implantados em defeitos ósseos críticos em calvária de rato. Metodologia: Foram utilizados 20 ratos distribuídos em 2 grupos experimentais: Grupo GC (controle com coágulo) e Grupo GBS (implantados com hidroxiapatita bovina) nos quais foi efetuado um defeito crítico de 8,5 mm de diâmetro na calvária. A eutanásia foi realizada em dois pontos biológicos, aos 15 e 45 dias pós-operatórios e os espécimes foram processados para inclusão em parafina. Os cortes histológicos foram corados pela técnica de hematoxilina e eosina (HE), e picrossírius-vermelho (PIFG), e foram analisados histologicamente em microscópio de luz comum. Resultados: No grupo controle, observou-se, neoformação óssea reacional restrita às bordas e presença de tecido fibroso na área do defeito. No grupo implantado com BioOss®, observouse mínima reação inflamatória, abundante angiogênese e alguma osteogênese, além das bordas, ao longo do defeito, especialmente em continuidade à dura-máter. Conclusão: Concluiu-se que o BioOss® foi biocompatível e promoveu osteogênese por osteocondução, mantendo-se parcialmente integrado ao osso neoformado. Salvador

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results