1. An Infection-Responsive Approach To Reduce Bacterial Adhesion in Urinary Biomaterials.
- Author
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McCoy CP, Irwin NJ, Brady C, Jones DS, Carson L, Andrews GP, and Gorman SP
- Subjects
- Anti-Infective Agents chemistry, Anti-Infective Agents pharmacology, Biocompatible Materials pharmacology, Biofilms drug effects, Catheter-Related Infections prevention & control, Nalidixic Acid chemistry, Nalidixic Acid pharmacology, Urinary Tract Infections prevention & control, Bacterial Adhesion drug effects, Biocompatible Materials chemistry, Methacrylates chemistry
- Abstract
Infection is an inevitable consequence of chronic urinary catheterization with associated problems of recurrent catheter encrustation and blockage experienced by approximately 50% of all long-term catheterized patients. In this work, we have exploited, for the first time, the reported pathogen-induced elevation of urine pH as a trigger for "intelligent" antimicrobial release from novel hydrogel drug delivery systems of 2-hydroxyethyl methacrylate and vinyl-functionalized nalidixic acid derivatives, developed as candidate infection-resistant urinary catheter coatings. Demonstrating up to 20-fold faster rates of drug release at pH 10, representing infected urine pH, than at pH 7 and achieving reductions of up to 96.5% in in vitro bacterial adherence, our paradigm of pH-responsive drug delivery, which requires no external manipulation, therefore represents a promising development toward the prevention of catheter-associated urinary tract infections in vivo.
- Published
- 2016
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