1. miR-146a promoted breast cancer proliferation and invasion by regulating NM23-H1
- Author
-
Xiao-Cheng Jiang, De-Quan Li, Jun Chen, Xue-Qin Jiang, Qiang Jiang, Xiaobo Wu, and Yali Cao
- Subjects
Breast Neoplasms ,Biochemistry ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,In vivo ,medicine ,Tumor Cells, Cultured ,Humans ,skin and connective tissue diseases ,Molecular Biology ,Pathological ,Luciferase reporter gene ,030304 developmental biology ,Cell Proliferation ,0303 health sciences ,business.industry ,Invasion and migration ,General Medicine ,NM23 Nucleoside Diphosphate Kinases ,medicine.disease ,MicroRNAs ,030220 oncology & carcinogenesis ,Cancer research ,Female ,Cancer cell lines ,business ,Human breast - Abstract
The study aimed to investigate the regulatory effect of miR-146a in proliferation, invasion and migration of breast cancer and its possible mechanism via NM23-H1. The expression levels of miR-146a in breast cancer with different pathological classification were significantly increased, while the expression levels of NM23-H1 were significantly decreased, which were closely correlated. Double luciferase reporter gene was used to verify the target regulatory relationship between miR-146 and NM23-H1 on a human breast cancer cell line. miR-146a was closely related to the proliferation and metastasis of breast cancer. miR-146a also promoted the growth of breast cancer in vivo via targeting NM23-H1. In conclusion, miR-146 can promote the proliferation and invasion of breast cancer by targeting NM23-H1.
- Published
- 2019