5 results on '"Shihui Huang"'
Search Results
2. Methylone Pre-Exposure Differentially Impacts the Aversive Effects of MDPV and MDMA in Male and Female Sprague-Dawley Rats: Implications for Abuse Vulnerability
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Hayley N. Manke, Katharine H. Nelson, Shihui Huang, Jacob M. Bailey, Sara K. Bowman, Robert A. Jones, Sydney E. Cerveny, Kenner C. Rice, and Anthony L. Riley
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Pharmacology ,Male ,History ,Pyrrolidines ,Dose-Response Relationship, Drug ,Polymers and Plastics ,Substance-Related Disorders ,N-Methyl-3,4-methylenedioxyamphetamine ,Clinical Biochemistry ,Toxicology ,Biochemistry ,Industrial and Manufacturing Engineering ,Methamphetamine ,Rats ,Rats, Sprague-Dawley ,Behavioral Neuroscience ,Animals ,Central Nervous System Stimulants ,Female ,Benzodioxoles ,Business and International Management ,Biological Psychiatry - Abstract
Polydrug use is well documented in synthetic cathinone users, although the consequences of such use are not well characterized. In pre-clinical research, a pre-exposure to a drug has been reported to attenuate the aversive effects of other drugs which has implications for their abuse potential. The goal of the present study was to investigate the impact of pre-exposure to the synthetic cathinone methylone on the aversive effects of MDPV and MDMA.Male and female Sprague-Dawley rats were exposed to 10 mg/kg of methylone every 4th day (for a total of five injections) prior to taste avoidance training with 1.8 mg/kg of MDPV or 1 mg/kg of MDMA.MDPV and MDMA induced taste avoidance in males and females (all p's 0.05). In males, methylone pre-exposure attenuated the avoidance induced by MDPV and MDMA (all p's 0.05) with the attenuation greater with MDPV. In females, methylone pre-exposure attenuated avoidance induced by MDPV (all p's 0.05), but it had no effect on those induced by MDMA (all p's 0.05).The effects of exposure to methylone on taste avoidance induced by MDPV and MDMA were drug- (MDPVMDMA) and sex- (MDMA only in males) dependent. The attenuating effects of methylone pre-exposure on MDPV and MDMA were discussed in terms of their shared neurochemical action. These findings suggest that a history of methylone use may reduce the aversive effects of MDPV and MDMA which may have implications for polydrug use involving the synthetic cathinones.
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- 2022
3. Ethanol pre-exposure differentially impacts the rewarding and aversive effects of α-pyrrolidinopentiophenone (α-PVP): Implications for drug use and abuse
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Katharine H. Nelson, Shihui Huang, Kenner C. Rice, Jacob M. Bailey, Anthony L. Riley, Anna Vlachos, Tania D. Weiss, Karina J. Maradiaga, and Hayley N. Manke
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Drug ,Male ,Taste ,Pyrrolidines ,Substance-Related Disorders ,media_common.quotation_subject ,Clinical Biochemistry ,Conditioning, Classical ,Self Administration ,Pharmacology ,Toxicology ,Biochemistry ,Article ,Body Temperature ,Rats, Sprague-Dawley ,Behavioral Neuroscience ,chemistry.chemical_compound ,Alkaloids ,Reward ,Pentanones ,Avoidance Learning ,Medicine ,Animals ,Reactivity (psychology) ,Biological Psychiatry ,media_common ,Ethanol ,business.industry ,Conditioned place preference ,Rats ,chemistry ,Body Temperature Changes ,Conditioning ,Central Nervous System Stimulants ,business ,Locomotion ,Bath salts - Abstract
Rationale Exposure to a drug can subsequently impact its own reactivity as well as that of other drugs. Given that users of synthetic cathinones, i.e., “bath salts”, typically have extensive and varied drug histories, an understanding of the effects of drug history on the behavioral and physiological consequences of synthetic cathiones may be important to their abuse liability. Objectives The goal of the current work was to assess the effects of an ethanol pre-exposure on the rewarding and aversive effects of α-PVP. Methods Adult male Sprague Dawley rats were exposed to ethanol prior to combined conditioned taste avoidance/conditioned place preference training in which rats were injected with 1.5, 3 or 5 mg/kg of racemic α-PVP or vehicle. Following a 7-day washout period, rats were then tested for thermoregulatory effects of α-PVP using subcutaneous probes to measure body temperature changes over the course of 8 h. This was followed 10 days later by assessments for α-PVP-induced locomotor activity and stereotypies over a 1-h session. Results α-PVP induced significant dose- and trial-dependent taste avoidance that was significantly attenuated by ethanol history and dose- and time-dependent increases in locomotor activity that were significantly increased by ethanol. α-PVP also induced place preferences and dose- and time-dependent increases in body temperature, but these measures were unaffected by ethanol history. Conclusions α-PVP's aversive effects (as measured by taste avoidance) were attenuated, while its rewarding effects (as indexed by place preference conditioning) were unaffected, by ethanol pre-exposure. Such a pattern may indicate increased α-PVP abuse liability, as changes in the balance of aversion and reward may impact overall drug effects and likelihood of drug intake. Future self-administration studies will be necessary to explore this possibility.
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- 2021
4. Environmental filtering dominates bacterioplankton community assembly in a highly urbanized estuarine ecosystem
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Shihui Huang, Zelong Zhao, Zonghe Yu, Zongyang Li, Pengfei Wang, Hongzhao Gong, Wenjing Huang, and Lei Zhou
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Wet season ,Aquatic Organisms ,Biogeochemical cycle ,Ecological health ,Biodiversity ,010501 environmental sciences ,01 natural sciences ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Rivers ,RNA, Ribosomal, 16S ,Ecosystem ,030212 general & internal medicine ,0105 earth and related environmental sciences ,General Environmental Science ,geography ,geography.geographical_feature_category ,Ecology ,Community structure ,Estuary ,Bacterioplankton ,Environmental science ,Seasons ,Estuaries - Abstract
Estuaries are important in terms of biodiversity, biogeochemical function, and ecological balance due to their intense land-sea interactions. The sustainability of estuarine ecosystem function relies on a good understanding of the ecological processes related to microbial communities. However, microbial community assembly in such ecosystems is still not well understood. Here, based on 16S rRNA sequencing, we investigated the bacterioplankton community structure in the Pearl River Estuarine system during the wet and dry seasons. Results showed that there were significant seasonal and spatial variations in the bacterioplankton communities of the estuary, with seasonal variations being more remarkable. Multiple bacterioplankton with different abundances in the wet and dry seasons were observed, e.g., the class Actinobacteria and Oxyphotobacteria were enriched in the wet season, whereas Alphaproteobacteria and Saccharimonadia were more abundant in the dry season. Both variation partitioning and null model analysis revealed that environmental filtering dominated the bacterioplankton community assembly in the Pearl River Estuary. Water physical properties (e.g., salinity and temperature), nutrient content (e.g., nitrate), and upstream land use (e.g., urban land cover) together determined the distribution of the bacterioplankton composition in this highly urbanized estuarine ecosystem. These findings would help improve our understanding of the bacterioplankton communities in estuarine ecosystems and provide a theoretical foundation for estuarine ecological health management.
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- 2021
5. Towards a tailored indoor horticulture: a functional genomics guided phenotypic approach
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Xinyun Liu, Huiting An, Nuo Xu, Shihui Huang, Xutong Pan, Aloysius Wong, Claudius Marondedze, Cindy Wong, Xuechen Tian, Xuan Zhou, Physiologie cellulaire et végétale (LPCV), Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Wenzhou Medical University, Partenaires INRAE, University of Toronto, Student-partnering-with-Faculty (SpF) program of Wenzhou-Kean University, Zhejiang China WKU201718009, Office of Research and Sponsored Programs of Wenzhou-Kean University, and Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG)
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0106 biological sciences ,0301 basic medicine ,Plant growth ,Botanics ,caractère phénotypique ,Mini Review ,génomique fonctionnelle ,Plant Science ,Biology ,01 natural sciences ,Biochemistry ,03 medical and health sciences ,Electric light ,lcsh:Botany ,Genetics ,Plant traits ,lcsh:QH301-705.5 ,2. Zero hunger ,business.industry ,fungi ,horticulture ,food and beverages ,[SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics ,Sustainable food production ,lcsh:QK1-989 ,Light quality ,Botanique ,Horticulture ,030104 developmental biology ,lcsh:Biology (General) ,Agriculture ,Plant species ,business ,Functional genomics ,010606 plant biology & botany ,Biotechnology - Abstract
As indoor horticulture gathers momentum, electric (also termed artificial) lighting systems with the ability to generate specific and tunable wavelengths have been developed and applied. While the effects of light quality on plant growth and development have been studied, authoritative and reliable sets of light formulae tailored for the cultivation of economically important plants and plant traits are lacking as light qualities employed across laboratories are inconsistent. This is due, at least in part, to the lack of molecular data for plants examined under electric lights in indoor environments. It has hampered progress in the field of indoor horticulture, in particular, the transition from small-scale indoor farming to commercial plant factories. Here, we review the effects of light quality on model and crop plants studied from a physiological, physical and biochemical perspective, and explain how functional genomics can be employed in tandem to generate a wealth of molecular data specific for plants cultivated under indoor lighting. We also review the current state of lighting technologies in indoor horticulture specifically discussing how recent narrow-bandwidth lighting technologies can be tailored to cultivate economically valuable plant species and traits. Knowledge gained from a complementary phenotypic and functional genomics approach can be harvested not only for economical gains but also for sustainable food production. We believe that this review serves as a platform that guides future light-related plant research., Indoor horticulture: Lighting the way to sustainability Tailored multidisciplinary approaches to hone sustainable indoor horticulture could significantly improve plant yields and crop quality. Advances in artificial lighting systems could transform commercial-scale indoor horticulture, but the current technology is limited by a lack of molecular data for plants grown under such lighting schemes. Aloysius Wong at Wenzhou-Kean University in Wenzhou, China, and co-workers reviewed research into the effects of light quality and differing wavelengths on plant growth. The team advocate the use of plant type-specific and functional genomics studies to examine light-determined molecular traits and associated gene expression. These could be used to build an extensive catalog of light qualities that enhance indoor crop yields and quality. Combining LED lights of different colors and wavelengths shows promise, and the researchers highlight the potential of tunable narrow wavelength lights, such as lasers.
- Published
- 2018
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