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Your search keyword '"Qiuzhe Xie"' showing total 2 results
Start Over Author "Qiuzhe Xie" Topic biochemistry
2 results on '"Qiuzhe Xie"'

1. Asymmetric Catalysis Route to anti,anti Stereotriads, Illustrated by Applications

Author

Qiuzhe Xie and Kathlyn A. Parker

Subjects
Ephedrine, Biological Products, Molecular Structure, Chemistry, Stereochemistry, Organic Chemistry, Scytophycin C, Enantioselective synthesis, Stereoisomerism, Sequence (biology), Bridged Bicyclo Compounds, Heterocyclic, Biochemistry, Catalysis, Lactones, Polyketide, Aplyronine A, Depsipeptides, Serine, Macrolides, Physical and Theoretical Chemistry, Enantiomer, Chirality (chemistry)
Abstract

A short sequence based on asymmetric catalysis, chirality transfer, and an optimized carbometallation protocol gave an anti,anti stereotriad building block in six steps. Both enantiomers of the chirality source, N-methyl ephedrine, are inexpensive, and the auxiliary is recoverable. In one chiral series, the building block was converted to the "B-2" intermediate in Miyashita's synthesis of scytophycin C; in the enantiomeric series, it was converted to a key intermediate for aplyronine A and to the polyketide "cap" for the callipeltins.

Published
2008

2. A relay ring-closing metathesis synthesis of dihydrooxasilines, precursors of (Z)-iodo olefins

Author

Qiuzhe Xie, Kathlyn A. Parker, and Richard W. Denton

Subjects
Silanes, Chemistry, Organic Chemistry, Stereoisomerism, Alkenes, Metathesis, Ring (chemistry), Biochemistry, Combinatorial chemistry, Catalysis, Article, chemistry.chemical_compound, Ring-closing metathesis, Yield (chemistry), Ring-opening metathesis polymerisation, Organic chemistry, Physical and Theoretical Chemistry, Iodine
Abstract

A convenient Grubbs II metathesis provides dihydrooxasilines by relay RCM (RRCM). Dihydrooxasilines undergo ring opening to give Z-vinyl silanes. These can then be converted to Z-vinyl iodides. This sequence provides a short, high yield, and convenient route to trisubstituted Z-vinyl iodides, useful intermediates for the preparation of polypropionate antibiotics.

Published
2008

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