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N-ortho-ferrocenyl benzoyl dipeptide esters 2–6 were prepared by coupling ortho-ferrocenyl benzoic acid 1 to the dipeptide ethyl esters GlyGly(OEt) (2), GlyAla(OEt) (3), GlyPhe(OEt) (4), AlaGly(OEt) (5) and AlaPhe(OEt) (6). The compounds were fully characterized by a range of NMR spectroscopic techniques, mass spectrometry and cyclic voltammetry. The cytotoxicity of 3 and 5 towards lung cancer cells has been determined.

A series of N -(ferrocenylmethyl)benzene-carboxamide derivatives ( 4a – f ) have been synthesised by coupling ferrocenylmethyl amine 3 with benzoic acid and various substituted fluorobenzoic acids using the standard 1,3-dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBt) protocol. All compounds were fully characterised using a combination of 1 H NMR, 13 C NMR, 19 F NMR, DEPT-135, 1 H– 1 H COSY and 1 H– 13 C COSY (HMQC) spectroscopy and electrospray ionisation mass spectrometry (ESI-MS). The compounds 4a , 4d , 4e and 4f exhibited cytotoxic effects on the MDA-MB-435-S-F breast cancer cell line. Single crystal X-ray crystallographic data for 4d is also presented.

A series of N - para -ferrocenyl benzoyl dipeptide esters 2 – 5 were prepared by coupling para -ferrocenyl benzoic acid ( 1 ) to the dipeptide ethyl esters using the conventional 1,3-dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBt) protocol. The dipeptides employed in the synthesis were Ala-Gly(OEt) ( 2 ), Ala-Ala(OEt) ( 3 ), Ala-Leu(OEt) ( 4 ) and Ala-Phe(OEt) ( 5 ). The compounds were fully characterized by a range of NMR spectroscopic techniques, electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (MS/MS). In addition the X-ray crystal structure of the l -alanine-glycine derivative 2 has been determined.

A series of N - ortho -ferrocenyl benzoyl amino acid ethyl esters 3 – 9 have been prepared by coupling ortho -ferrocenyl benzoic acid 2 to the amino acid ethyl esters of glycine, l -alanine, l -leucine, l -phenylalanine, β-alanine, 4-aminobutyric acid and (±)-2-aminobutyric acid using the conventional 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole protocol. The compounds were fully characterized by a range of NMR spectroscopic techniques and by mass spectrometry (MALDI-MS, ESI-MS). The X-ray crystal structure of the l -phenylalanine derivative 6 has been determined.