1. Lower Blood Oxygen Saturation is Associated With Microvascular Complications in Individuals With Type 1 Diabetes
- Author
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Jens Christian Laursen, Hatice Isik Mizrak, Huda Kufaishi, Sofie Korsgaard Hecquet, Elisabeth Buur Stougaard, Ninna Hahn Tougaard, Marie Frimodt-Møller, Tine Willum Hansen, Christian Stevns Hansen, and Peter Rossing
- Subjects
Diabetic Retinopathy ,Endocrinology, Diabetes and Metabolism ,Biochemistry (medical) ,Clinical Biochemistry ,Biochemistry ,Diabetes Mellitus, Type 1 ,Cross-Sectional Studies ,Endocrinology ,Oxygen Saturation ,Risk Factors ,Cardiovascular Diseases ,Humans ,Albuminuria ,Diabetic Nephropathies ,Hypoxia - Abstract
Context Blood oxygen saturation (SpO2) is lower in type 1 diabetes (T1D) compared with nondiabetic controls. Hypoxia (low tissue oxygenation) is thought to be a risk factor for progression of diabetic complications, but it is unknown whether hypoxemia (low SpO2) is associated with diabetic complications. Objective To test if hypoxemia is associated with presence of diabetic complications in T1D. Design, Setting, and Methods Cross-sectional study in persons with T1D divided by a previously suggested threshold in low ( Results We included 659 persons, 23 (3.5%) with low and 636 (96.5%) with high SpO2. In total, 151 (23%) had albuminuria, 233 (36%) had retinopathy, 231 (35%) had neuropathy, and 72 (11%) had CVD. The adjusted odds ratio (95% CI, P value) for low vs high SpO2 was 3.4 (1.3-8.7, P = 0.01) for albuminuria, 2.8 (1.0-7.5, P = 0.04) for retinopathy, 5.8 (1.8-18.6, P < 0.01) for neuropathy, and nonsignificant for CVD (0.6 [0.2-2.4, P = 0.51]). Conclusions SpO2 below 96% was associated with increased presence of albuminuria, retinopathy, and neuropathy in T1D, but not with CVD. Whether hypoxemia could be a target of intervention to prevent progression in microvascular disease in type 1 diabetes should be investigated.
- Published
- 2022
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