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Shimmer, Tangle, Deep, Dark, Wet is an exploration of the possibilities of the publication, the underwater world, editorial work and an investigation in different materials. The work includes among other things, a professional mermaid, a marine geologist, three underwater rugby players, and a poem about the waves in the Persian Gulf. Skimmer, trassel, djupt, mörkt, blött är ett utforskande av publikationens möjligheter, världen under vatten, redaktionellt arbete och ett experimenterande med olika material. Arbetet innehåller bland annat en professionell sjöjungfru, en maringeolog, tre undervattensrugbyspelare och en dikt om vågorna i persiska viken.

Papers and old books are important part of museum collections in many museums in Yogyakarta, even some of them have very significant value and become masterpiece collections. Some old books such as from Islamic and colonial period have unique binding structures that should be preserved too as it become a historical marker. Therefore, special care for paper collections and old books should be carried out by museum conservator. Unfortunately, not all museums in Yogyakarta have professional conservator. Bear in mind that many museums in Yogyakarta has significant value of paper collection, a workshop of paper conservation was conducted on 18-19 September 2019 in Museum UGM, as a community service for museum communities in Yogyakarta. Through this workshop, participants managed to identify types of damage on paper collections, identify the cause of damage, and conduct simple interventive conservation.====Kertas dan buku tua merupakan bagian penting dari koleksi museum di banyak museum di Yogyakarta, bahkan beberapa memiliki nilai yang sangat penting dan menjadi koleksi istimewa. Beberapa buku tua, contohnya dari masa Islam dan kolonial, memiliki struktur jilid yang unik yang juga harus dilestarikan karena menjadi penanda sejarah. Maka dari itu, penanganan khusus untuk koleksi kertas dan buku tua harus dilakukan oleh konservator museum. Sayangnya, tidak semua museum di Yogyakarta memiliki konservator profesional. Mengingat bahwa banyak museum di Yogyakarta memiliki koleksi kertas dengan kandungan nilai penting, workshop konservasi kertas dilaksanakan pada 18—19 September 2019 di Museum UGM sebagai bentuk pengabdian masyarakat kepada komunitas museum di Yogyakarta. Melalui workshop ini, peserta berhasil mengidentifikasi tipe kerusakan dan penyebabnya pada koleksi kertas serta melakukan konservasi interventif sederhana pada koleksi kertas.

Bacteriophage (phage), which are viruses that infect bacteria only, have shown promise as vehicles for targeted cancer gene therapy, albeit with poor efficiency. Recently, we generated an improved version of phage vectors by incorporating cis genetic elements of adeno‐associated virus (AAV). This novel AAV/phage hybrid (AAVP) efficiently delivered systemically administered therapeutic genes to various tumor targets by displaying an integrin tumor‐targeting ligand on the phage capsid. However, inherent limitations in bacteriophage mean that these AAVP vectors still need to be improved. One of the limitations of AAVP in mammalian cells may be its susceptibility to proteasomal degradation. The proteasome is upregulated in cancer and it is known that it constitutes a barrier to gene delivery by certain eukaryotic viruses. We report here that inhibition of proteasome improved targeted reporter gene delivery by AAVP in cancer cells in vitro and in tumors in vivo after intravenous vector administration to tumor‐bearing mice. We also show enhanced targeted tumor cell killing by AAVP upon proteasome inhibition. The AAVP particles persisted significantly in cancer cells in vitro and in tumors in vivo after systemic administration, and accumulated polyubiquitinated coat proteins. Our results suggest that the proteasome is indeed a barrier to tumor targeting by AAVP and indicate that a combination of proteasome‐inhibiting drugs and AAVP should be considered for clinical anticancer therapy., Highlights ► Proteasome in cancer is a barrier to tumor targeting by RGD4C/AAVP.► Proteasome inhibiting drugs enhance targeted gene transfer by RGD4C/AAVP.► Proteasome inhibition increases targeted cancer gene therapy by RGD4C/AAVP.► RGD4C/AAVP persistence in cancer is improved by proteasome inhibition

This paper sets out to underline the important role of Hispano-Arabic culture in the technological advances related to the different techniques of bookmaking: parchment, paper and binding. As the subject is quite broad we shall only outline a few important questions, as most of the studies in these matters, paradoxical though it may seem, have been carried outside Spain (most of them in France, as we can see by the bibliography quoted). It would therefore be very interesting if the new generations of Spanish scholars became interested in studying this subject in depth, since these advances and their expansion throughout the Mediterranean gave rise to the cultural flowering of the Renaissance.Este artículo pretende poner de manifiesto la importancia que tuvo la cultura hispano-árabe para los avances tecnológicos producidos en las diferentes técnicas implicadas en la elaboración del libro: pergamino, papel y encuadernación. Somos conscientes que, dada la amplitud del tema, sólo vamos a esbozar una serie de cuestiones que consideramos fundamentales ya que la mayoría de los estudios sobre estas materias, aunque parezca paradójico, se han realizado fuera de nuestras fronteras, sobre todo en Francia, como podemos ver por la bibliografía citada. Por lo tanto sería muy interesante que las nuevas generaciones de estudiosos españoles se interesaran en profundizar en estas materias ya que estos avances y su expansión por todo el Mediterráneo dieron lugar a la eclosión cultural del Renacimiento.

Juraj Dalmatin’s Bible from 1584 is the first Slovene translation of a complete Bible. It is the greatest achievement of the Reformation period in Slovenia. The book is a Slovene cultural monument of the highest category and is an extraordinary work, considering both the content and the material it was made of. The copy of the Dalmatin Bible presented and analyzed in this paper was in active use for a very long time, the proof of which are the severe signs of damage caused by frequent use and inappropriate storage in the past. The conservation-restoration intervention was necessary because both the text block and the binding were badly damaged. The main purpose of the intervention was to examine the structure and materials, conserve and restore the leaves of the text block, restore the binding and conserve as much as possible the originality of the book., Dalmatinova Biblija iz 1584. prvi je slovenski prijevod cjelokupne Biblije. Najveće je dostignuće razdoblja reformacije u Sloveniji. Knjiga je slovenski kulturni spomenik najviše kategorije i izvaredno je djelo s obzirom na sadržaj i s obzirom na materijal. Primjerak Dalmatinove Biblije kojim se bavi rad, dugo je vremena bio u aktivnoj uporabi, što su potvrdili brojni primjeri oštećenja uzorovanih čestom upotrebom i neodgovarajućom pohranom u prošlosti. Konzervatorsko-restauratorska intervencija bila je neophodna zbog znatnog oštećenja knjižnog bloka i uveza. Glavna svrha intervencije bila je ispitati stukturu i materijale, konzervirati i restaurirati listove knjižnog bloka, restaurirati uvez i konzervirati na što je dulje moguće izvornost knjige.

A tough nut: A new approach to making biomimetic nanocomposites, involving engineered proteins (see scheme; green and blue), reinforcing graphene sheets (purple), and nanofibrillated cellulose (gray), is presented. The aligned co‐assembly of these components leads to a composite with remarkably good mechanical properties, which potentially arises from the role of the adhesive matrix proteins.

This paper sets out to underline the important role of Hispano-Arabic culture in the technological advances related to the different techniques of bookmaking: parchment, paper and binding. As the subject is quite broad we shall only outline a few important questions, as most of the studies in these matters, paradoxical though it may seem, have been carried outside Spain (most of them in France, as we can see by the bibliography quoted). It would therefore be very interesting if the new generations of Spanish scholars became interested in studying this subject in depth, since these advances and their expansion throughout the Mediterranean gave rise to the cultural flowering of the Renaissance. Este artículo pretende poner de manifiesto la importancia que tuvo la cultura hispano-árabe para los avances tecnológicos producidos en las diferentes técnicas implicadas en la elaboración del libro: pergamino, papel y encuadernación. Somos conscientes que, dada la amplitud del tema, sólo vamos a esbozar una serie de cuestiones que consideramos fundamentales ya que la mayoría de los estudios sobre estas materias, aunque parezca paradójico, se han realizado fuera de nuestras fronteras, sobre todo en Francia, como podemos ver por la bibliografía citada. Por lo tanto sería muy interesante que las nuevas generaciones de estudiosos españoles se interesaran en profundizar en estas materias ya que estos avances y su expansión por todo el Mediterráneo dieron lugar a la eclosión cultural del Renacimiento.

Major commercial bookbinding technique used today is perfect binding (or adhesive binding), originally used for paperback books. In perfect binding, adhesive is used to attach the pages of a book together and attach the book cover. One of most important criterion for adhesive binding is strength over the whole length of a book leaf. It is known that adhesion strength is function of the bond between the leaf and adhesive and total sum of material contact area. The subjects of research are physical properties of paper that have impact on different general sources of binding strength. The tests were performed with constant parameters of binding process and two chemically different types of paper.

International audience; Pycnoporus cinnabarinus laccase was fused to the C-terminal linker and carbohydrate binding module (CBM) of Aspergillus niger cellobiohydrolase B (CBHB). The chimeric enzyme of molecular mass 100 kDa was successfully produced in A. niger. Laccase-CBM was further purified to determine its main biochemical properties. The Michaelis-Menten constant and pH activity profile were not modified, but the chimeric enzyme was less thermostable than either the P. cinnabarinus laccase or the recombinant laccase produced in the same strain. Laccase-CBM was able to bind to a cellulosic substrate and, to a greater extent, to softwood kraft pulp. Binding to the pulp was shown to be mainly time and temperature-dependent. Laccase-CBM was further investigated for its softwood kraft pulp biobleaching potential and compared with the P. cinnabarinus laccase. Addition of a CBM was shown to greatly improve the delignification capabilities of the laccase in the presence of 1-hydroxybenzotriazole (HBT). In addition, ClO2 reduction using 5 U of chimeric enzyme per gram of pulp was almost double than that observed using 20 U of P. cinnabarinus laccase per gram of pulp. We demonstrated that conferring a carbohydrate binding capability to the laccase could significantly enhance its biobleaching properties